Phosphodiesterase inhibitors piroximone and enoximone inhibit platelet aggregation in vivo and in vitro

Thrombosis Research

Volumn 88, Issue 2, 1997, Pages 89-98

  Buerke, Michael ^a   Cyrus, Tillmann ^a   Darius, Harald ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

cAMP; Enoximone; PDE inhibitor; Piroximone; Platelet aggregation

Indexed keywords

COLLAGEN; ENOXIMONE; PHOSPHODIESTERASE INHIBITOR; PIROXIMONE;

CALCIUM MOBILIZATION; CARDIOVASCULAR DISEASE; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME INHIBITION; HEART FAILURE; HEART FUNCTION; HUMAN; INOTROPISM; NORMAL HUMAN; PRIORITY JOURNAL; REVIEW; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; VASODILATATION;

EID: 0030662219     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(97)00221-1     Document Type: Article

References (19)

1. LEIER CV. Current status of non-digitalis positive inotropic drugs. Am J Cardiol 1992; 69: 120G-8G.
2. ERBEL R, MEYER J, DIEFENBACH C, DELORME G, BOURDARIAS JP, VERNANT P, LELLOUCHE D, MATTIOLI G, BARBIERI A, INSTALLE E, GONZALEZ M, MITROVIC V, NEUZNER J, SALVADE G. A dose-response study of intravenous enoximone in congestive heart failure. Am J Cardiol 1987; 59: 31C-6C.
3. DARIUS H, BUERKE M, CYRUS T, ERBEL R, MEYER J. Hemodynamic effects of the phosphodiesterase inhibitor piroximone in patient with severe heart failure. submitted for publication.
4. RACKER M, CARVER JR, RODEHEFFER RJ. Effect of oral milrinone on mortality in severe heart failure. N Engl J Med 1991; 325 1468-75.
5. MONCADA S, KORBUT R. Dipyridamole and other phosphodiesterase inhibitors act as antithrombotic agents by potentiating endogenous prostacyclin. Lancet 1978; : 1286-9.
6. SALZMAN EW. Cyclic AMP and platelet function. N Engl J Med 1972; 286: 358-63.
7. MILLS DCB, SMITH JB. The influence on platelet aggregation of drugs that affect the accumulation of adenosin 3′:5′-cyclic monophosphate in platelets. Biochem J 1971; 121: 185-96.
8. DARIUS H, LEFER AM. Antiaggregatory effects of thromboxane receptor antagonists in vivo. Thromb Res 1985; 40: 663-75.
9. DARIUS H, LEFER AM, LEPRAN I, SMITH B. In vivo interaction of prostacyclin with an inhibitor of cyclic nucleotide phosphodiesterase, HL 725. Br J Pharmacol 1985; 84: 735-41.
10. SMITH JB. Effect of the thromboxane synthase inhibitors on platelet function: enhancement by inhibition of phosphodiesterase. Thromb Res 1982; 28: 477-85.
11. WEISHAAR RE, CAIN MH, BRISTOL JA. A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. J Med Chem 1985; 28: 537-45.
12. WEISHAAR RE, BUROWS SD, KOBYLAZ DC, QUADE MM, EVANS DB. Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets. Biochem Pharmacol 1986; 35: 787-800.
13. BORN GVR. Aggregation of blood platelets by adenosindiphosphate and its reversal. Nature 1962; 1962: 927-9.
14. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260: 3440-50.
15. SELAK AS, SMITH JB. Platelet-activating factor-induced calcium mobilization in human platelets and neutrophils: effects of PAF-acether antagonists. J Lipid Med 1989; 1: 125-37.
16. PATTISON A, ASTLEY N, EASON CT, BONNER FW. A comparison of the effects of three positive inotropic agents (amrinone, milrinone and medorinone) on platelet aggregation in human whole blood. Thromb Res 1990; 57: 909-18.
17. KITZEN JM, MCCALLUM JD, PIROZZI C, COLATSKY TJ. Potentiation of phosphodiesterase inhibitor antithrombotic activity with alpha-2 adrenergic blockade. Life Sci 1991; 48: P131-5.
18. ROMSON JL, HOOK G, LUCCHESI. Potentiation of the antithrombotic effect of prostacyclin by simultaneous administration of aminophylline in a canine model of coronary artery thrombosis. J Pharmacol Exper Therap 1983; 227: 288-94.
19. SMITH III EF, EGAN JW. Comparison of the effects of a thromboxane synthase inhibitor or prostacyclin in combination with a phosphodiesterase inhibitor for prevention of experimental thrombosis and sudden death in rabbits. J Pharmacol Exper Therap 1987; 241: 855-60.