Measurement of molecular association in drug: Cyclodextrin inclusion complexes with improved 1H NMR studies

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 10, 1997, Pages 944-948

  Loukas, Yannis L ^a,b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b NONE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLODEXTRIN; HALOPERIDOL;

ARTICLE; BINDING AFFINITY; DRUG BINDING; MATHEMATICAL MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; REGRESSION ANALYSIS; STOICHIOMETRY;

EID: 0030662042     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06021.x     Document Type: Article

References (15)

1. Armstrong, D., Nome, F., Spino, L., Golden, T. (1986) Efficient detection and evaluation of cyclodextrin multiple complex formation. J. Am. Chem. Soc. 108: 1418-1423
2. Connors, K. A. (1987) Binding Constant, The measurement of Molecular Complex Stability. John Wiley, New York, p. 386
3. Diedrich, F. (1988) Complexation of neutral molecules by cyclophane hosts. Angew. Chem. Int. Ed. Engl. 27: 362-368
4. Djedaini, F., Perly, B. (1993) Nuclear magnetic resonance of cyclodextrins, derivatives and inclusion compounds. In: Duchene, D. (ed.) New Trends in Cyclodextrins and Derivatives. 1st edn, Edition de Sante, Paris, pp 215-247
5. Djedaini, F., Lin, S. Z., Perly, B., Wouessidjewe, D. (1990) High-field nuclear magnetic resonance techniques for the investigation of a beta-cyclodextrin:indomethacin inclusion complex. J. Pharm. Sci. 79: 643-646
6. Ferguson, S. B., Diederich, F. (1986) Electron donor-acceptor interactions in host-guest complexes in organic solutions. Angew. Chem. Int. Ed. Engl. 25: 1127-1128
7. Loukas, Y. L. (1995) Complexation of haloperidol with a water-soluble β-cyclodextrin polymer: characterization of the inclusion complex in solid state and in aqueous solution. Pharm. Sci. 1: 509-512
8. Loukas, Y. L. (1997a) Multiple complex formation of fluorescent compounds with cyclodextrins: efficient determination and evaluation of the binding constant with improved fluorimetric studies. J. Phys. Chem. B. 101: 4863-4866
9. Loukas, Y. L. (1997b) Multiple complex formation of unstable compounds with cyclodextrins: efficient determination and evaluation of the binding constant with improved kinetic studies. Analyst 122: 377-381
10. Loukas, Y. L., Antoniadou-Vyza, E., Valiraki, A. (1995) Inclusion complexes and stability studies of an organophosphorus insecticide with cyclodextrins: spectrophotometric and kinetic determination of stability constant. Analyst 120: 533-599
11. Loukas, Y. L., Vraka, V., Gregoriadis, G. (1997) New non-acidic formulations of haloperidol complexed with β-cyclodextrin derivatives. J. Pharm. Biomed. Anal. In press
12. Miyahara, M., Takahashi, T. (1982) Determination of stability constants of complexes by the non-linear optimization method and analysis of solubility curves. Chem. Pharm. Bull. 30: 288-295
13. Saenger, W. (1980) Cyclodextrin inclusion complexes in research and industry. Angew. Chem. Int. Ed. Engl. 19: 344-362
14. Schneider, H. J., Philippi, K., Pohlmann, J. (1984) Structure- and solvent-dependence in the Complexation of lipophilic substrates in a water-soluble azacyclophane. Angew. Chem. Int. Ed. Engl. 23: 908-909
15. Schneider, H. J., Kramer, R., Simova, S., Schneider, U. (1988) Solvent and salt effects on binding constants of organic substrates in macrocyclic host compounds. A general equation measuring hydrophobic binding contributions. J. Am. Chem. Soc. 110: 6442-6448