Effects of two N-arylpiperazinylmethylpyrazolo [1,5-d][1,2,4]triazine derivatives in pain and antidepressant tests in mice

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 10, 1997, Pages 1019-1024

  Rubat, C ^a   Coudert, P ^a   Mavel, S ^b   Fialip, J ^a   Couquelet, J ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b UNIVERSITÉ DE TOURS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENYL 3,3 ALPHA DIHYDRO 4 OXO 5 (4 PHENYLPIPERAZIN 1 YL)METHYL PYRAZOLO [1,5D][1,2,4] TRIAZINE; 2 PHENYL 3,3ALPHA DIHYDRO 4 OXO 5 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]METHYLPYRAZOLO [1,5D][1,2,4] TRIAZINE; 5 HYDROXYTRYPTOPHAN; ALPHA 2 ADRENERGIC RECEPTOR; CARBIDOPA; METHYSERGIDE; MORPHINE; NALOXONE; OPIATE RECEPTOR; PHENYLQUINONE; PYRAZOLOTRIAZINE DERIVATIVE; RESERPINE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; YOHIMBINE;

ANALGESIA; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; FORCED SWIMMING TEST; HOT PLATE TEST; INTRAPERITONEAL DRUG ADMINISTRATION; LD 50; MALE; MOUSE; NONHUMAN; PAIN; PTOSIS; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030661915     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06034.x     Document Type: Article

References (37)

1. Ardid, D., Marty, H., Fialip, J., Privat, A. M., Eschalier, A., Lavarenne, J. (1992) Comparative effects of different uptake inhibitor antidepressants in two pain tests in mice. Fundam. Clin. Pharmacol. 6: 75-82
2. Bhattacharya, S. K. (1978) Imipramine-induced potentiation of morphine analgesia in the rat: role of brain monoamines. Indian J. Med. Res. 68: 849-854
3. Biegon, A., Samuel, D. (1980) Interaction of tricyclic antidepressants with opiate receptors. Biochem. Pharmacol. 29: 460-461
4. Botney, M., Fields, H. L. (1983) Amitriptyline potentiates morphine analgesia by a direct action on the central nervous system. Ann. Neurol. 13: 160-164
5. Deakin, J. F. W., Dostrovsky, J. D. (1978) Involvement of the periaqueductal gray matter and spinal 5-hydroxytryptamine pathways in morphine analgesia: effects of lesions of 5-hydroxytryptmine depletion. Br. J. Pharmacol. 63: 159-165
6. Eschalier, A., Montastruc, J. L., Devoize, J. L., Rigal, F., Gaillard-Plaza, G., Pechadre, J. C. (1981) Influence of naloxone and methysergide on the analgesic effect of clomipramine in rats. Eur. J. Pharmacol. 74: 1-7
7. Fialip, J., Marty, H., Makambila, M. C., Civiale, M. A., Eschalier, A. (1989) Pharmacokinetic patterns of repeated administration of antidepressant in animals. II. Their relevance in a study of the influence of clomipramine on morphine analgesia in mice. J. Pharmacol. Exp. Ther. 248: 741-751
8. Gouret, C., Thomas, J. (1973) Test du ptosis à la réserpine chez la souris. J. Pharmacol. (Paris) 4: 401-404
9. Granados-Soto, V., Flores-Murrieta, F. J., Castaneda-Hernandez, G., Hong, E., Lopez-Munoz, F. J. (1995) Evidence against the participation of μ- and κ-opioid receptors in the analgesic activity of ketorolac in rats. J. Pharm. Pharmacol. 47: 514-517
10. Isenberg, K. E., Cicero, T. J. (1984) Possible involvement of opiate receptors in the pharmacological profile of antidepressant compounds. Eur. J. Pharmacol. 103: 57-63
11. Kuraishi, Y., Harada, Y., Aratani, S., Satoh, M., Takagi, H. (1983) Separate involvement of the spinal noradrenergic and serotonergic systems in morphine analgesia: the differences in mechanical and thermal algesic tests. Brain. Res. 273: 245-252
12. 2-Agonists for analgesia. Emerging Drugs 1: 377-389
13. Lidbrink, P., Jonssen, G., Fuxe, K. (1971) The effects of imipramine-like drugs and antihistamine drugs on uptake mechanisms in the central noradrenaline and serotonin neurons. Neuropharmacology 10: 521-536
14. Linée, P. (1972) Test des crampes abdominales provoquées chez la souris par la phénylbenzoquinone. J. Pharmacol. (Paris) 3: 513-515
15. Litchfield, J. T., Wilcoxon, F. (1949) A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96: 99-113
16. Luttinger, D., Ferrari, R., Perrone, M. H., Haulbrich, D. R. (1985) Pharmacological analysis of alpha-2 adrenergic mechanisms in nociception and ataxia. J. Pharmacol. Exp. Ther. 232: 883-889
17. Malseed, R. T., Goldstein, F. J. (1979) Enhancement of morphine analgesia by tricyclic antidepressants. Neuropharmacology 18: 827-829
18. Mavel, S., Rubat, C., Coudert, P., Privat, A. M., Couquelet, J., Tronche, P., Bastide, P. (1993) Synthesis of new 5-substituted pyrazolo[1,5-d][1,2,4]triazine derivatives and their analgesic, antiinflammatory and antipyretic properties. Arzneimittelforschung 43: 464-468
19. Messing, R. B., Phebus, L., Fisher, L., Lytle, L. D. (1975) Analgesic effect of fluoxetine HCl (Lilly 110-140), a specific uptake inhibitor for serotonergic neurons. Psychopharmacol. Commun. 1: 511-521
20. Nevinson, M. J., Gray, A. M., Sewell, R. D. E. (1991) Antagonism of nefopam antinociception by naloxone and RX 821002. Br. J. Pharmacol.-Proc. Suppl. 104: 267P
21. Pertovaara, A. (1993) Antinociception induced by alpha-2-adrenoceptor agonists with special emphasis on medetomidine studies. Prog. Neurobiol. 40: 691-709
22. Porsolt, R. D., Bertin, A., Jalfre, M. (1977) Behavioural despair in mice: a primary screening test for antidepressants. Arch. Int. Pharmacodyn. 229: 327-336
23. Quinton, R. M. (1963) The increase in the toxicity of yohimbine-induced by imipramine and other drugs in mice. Br. J. Pharmacol. 21: 51-66
24. Raynaud, G., Gouret, C. (1973) Une nouvelle série d'antidépresseurs: les dérivés de l'hydroxyméthyl-5 oxazolidinone-2. II. Etude psychopharmacologique. Chim. Ther. 3: 328-337
25. Rubat, C., Coudert, P., Bastide, P., Tronche, P. (1995) Behavioural profile of two potential antidepressant pyridazine derivatives including arylpiperazinyl moieties in their structures in mice. J. Pharm. Pharmacol. 47: 162-170
26. Sawynok, J., Reid, A. R., Doak, G. J. (1995) Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms. Pain 61: 203-213
27. Schmitt, H., Le Douarec, J. C., Petillot, N. (1974) Antinociceptive effects of some α-sympathomimetic agents. Neuropharmacology 13: 289-294
28. Schwartz, D. (1984) Méthodes statistiques à l'usage des médecins et des biologistes, Flammarion (Editions Médicales), Paris
29. Siegmund, E., Cadmus, R., Lu, G. (1957) A method for evaluating both non-narcotic and narcotic analgesics. Proc. Soc. Exp. Biol. Med. 95: 729-731
30. Somoza, E., Galindo, A., Bazan, E., Guillamon, A., Valencia, A., Fuentes, J. A. (1981) Antidepressants inhibit enkephalin binding to synaptosome-enriched fractions of rat brain. Neuropsychobiology 7: 297-301
31. Taiwo, Y. O., Fabian, A., Pazoles, C. J., Fields, H. L. (1985) Potentiation of morphine antinociception by monoamine reuptake inhibitors in the rat spinal cord. Pain 21: 329-337
32. Valeri, P., Pimpinella, G., Morrone, L. A., Romanelli, L. (1991) Antinociceptive effects of trazodone and m-chlorophenylpiperazine (mCPP) in mice: interaction with morphine. Gen. Pharmacol. 22: 127-131
33. Vonvoigtlander, P. F., Lewis, R. A., Neff, G. L. (1984) Kappa opioid analgesia is dependent on serotonergic mechanisms. J. Pharmacol. Exp. Ther. 231: 270-274
34. Woolfe, G., McDonald, A. D. (1944) The evaluation of the analgesic action of pethidine hydrochloride (Demerol). J. Pharmacol. Exp. Ther. 80: 300-307
35. Yaksch, T. L. (1979) Direct evidence that spinal serotonin and noradrenaline terminals mediate the spinal antinociceptive effect of morphine in the periaqueductal gray. Brain Res. 160: 180-185
36. Yaksch, T. L., Elde, R. P. (1980) Release of methionine-enkephalin immunoreactivity from the rat spinal cord in vivo. Eur. J. Pharmacol. 63: 359-362
37. +-evoked release of serotonin and norepinephrine in vivo from the rat and cat spinal cord. Brain Res. 192: 133-146