Complement activation, its consequences, and blockade by gene transfer

World Journal of Surgery

Volumn 21, Issue 9, 1997, Pages 907-912

  Carrington, Christine A ^a   Richards, Andrew C ^a   Van Den Bogaerde, Johan ^a   Tucker, Alexander W ^a   White, David J G ^a  

^a Imutran Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; COMPLEMENT ACTIVATION; GENE TRANSFER; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNITY; IMMUNOREGULATION; NONHUMAN; XENOTRANSPLANTATION;

ACUTE DISEASE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIBODIES, HETEROPHILE; ANTIGENS, CD55; COMPLEMENT ACTIVATION; GENE TRANSFER TECHNIQUES; GRAFT REJECTION; HUMANS; ORGAN TRANSPLANTATION; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0030661873     PISSN: 03642313     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002689900325     Document Type: Article

References (58)

1. Gore, S.M., Cable, D.J., Holland, A.J.: Organ donation from intensive care units in England and Wales: two year confidential audit of deaths in intensive care. B.M.J. 304:349, 1992
2. Organ Shortage: The Solutions. Dordrecht, Kluwer Academic Publishers, 1995
3. Hammer, C., Dommer, S., Allmeling, A.: Cross species interaction of xenogeneic interleukins. Transplant. Proc. 28:858, 1996
4. Carrington, C.A., Richards, A., Peters, A.L., White, D.: Novel responses by transgenic pig endothelial cells to stimulation by human cytokines in terms of hDAF, E-selectin and major histocompatibility complex class II expression. Transplant. Proc. 29:550, 1997
5. Calne, R.Y.: Organ transplantation between widely disparate species. Transplant. Proc. 2:550, 1970
6. Reemtsma, K.: Heterotransplantation: theoretical considerations. Transplant. Proc. 3:49, 1971
7. Reemtsma, K.: Heterotransplantation. Transplant. Proc. 1:251, 1969
8. Reemtsma, K.: Renal heterotransplantation from nonhuman primates to man. Ann. N.Y. Acad. Sci. 162:412, 1969
9. Animal Tissue into Humans. A Report by the Advisory Group on the Ethics of Xenotransplantation, Department of Health. London, The Stationery Office, 1996
10. Arthur, G., Noakes, D., Pearson, H.: Pregnancy and parturition. In Veterinary Reproduction and Obstetrics. London, Bailliere Tindall, 1989
11. Galili, U.: Interaction of the natural anti-Gal antibody with alpha-galactosyl epitopes: a major obstacle for xenotransplantation in humans. Immunol. Today 14:480, 1993
12. Galili, U., Rachmilewitz, E.A., Peleg, A., Flechner, I.: A unique natural human IgG antibody with anti-alpha-galactosyl specificity. J. Exp. Med. 160:1519, 1984
13. Holzknecht, Z.E., Platt, J.L.: Identification of porcine endothelial cell membrane antigens recognized by human xenoreactive natural antibodies. J. Immunol. 154:4565, 1995
14. Oriol, R., Ye, Y., Koren, E., Cooper, D.K.: Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation. Transplantation 56:1433, 1993
15. Platt, J.L., Lindman, B.J., Chen, H., Spitalnik, S.L., Bach, F.H.: Endothelial cell antigens recognized by xenoreactive human natural antibodies. Transplantation 50:817, 1990
16. Sandrin, M.S., McKenzie, I.F.: Gal alpha (1,3)Gal, the major xenoantigen(s) recognised in pigs by human natural antibodies. Immunol. Rev. 141:169, 1994
17. Sandrin, M.S., Vaughan, H.A., Dabkowski, P.L., McKenzie, I.F.: Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopes. Proc. Natl. Acad. Sci. U.S.A. 90:11391, 1993
18. Latinne, D., Soares, M., Havaux, X., Cormont, F., Lesnikoski, B., Bach, F.H., Bazin, H.: Depletion of IgM xenoreactive natural antibodies by injection of anti-mu monoclonal antibodies. Immunol. Rev. 141:95, 1994
19. Pruitt, S.K., Baldwin, W.M., III, Barth, R.N., Sanfilippo, F.: The effect of xenoreactive antibody and B cell depletion on hyperacute rejection of guinea pig-to-rat cardiac xenografts. Transplantation 56:1318, 1993
20. Soares, M., Lu, X., Havaux, X., Baranski, A., Reding, R., Latinne, D., Daha, M., Lambotte, L., Bach, F.H., Bazin, H.: In vivo IgM depletion by anti-mu monoclonal antibody therapy: the role of IgM in hyperacute vascular rejection of discordant xenografts. Transplantation 57:1003, 1994
21. Forty, J., Hasan, R., Cary, N., White, D.J., Wallwork, J.: Hyperacute rejection of rabbit hearts by human blood is mediated by the alternative pathway of complement. Transplant. Proc. 24:488, 1992
22. Atkinson, J.P., Oglesby, T.J., White, D., Adams, E.A., Liszewski, M.K.: Separation of self from non-self in the complement system: a role for membrane cofactor protein and decay accelerating factor. Clin. Exp. Immunol. 86(Suppl. 1):27, 1991
23. Blakely, M.L., Van der Werf, W.J., Berndt, M.C., Dalmasso, A.P., Bach, F.H., Hancock, W.W.: Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection. Transplantation 58:1059, 1994
24. Platt, J.L., Fischel, R.J., Matas, A.J., Reif, S.A., Bolman, R.M., Bach, F.H.: Immunopathology of hyperacute xenograft rejection in a swine-to-primate model. Transplantation 52:214, 1991
25. Liszewski, M.K., Post, T.W., Atkinson, J.P.: Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster. Annu. Rev. Immunol. 9:431, 1991
26. Post, T.W., Arce, M.A., Liszewski, M.K., Thompson, E.S., Atkinson, J.P., Lublin, D.M.: Structure of the gene for human complement protein decay accelerating factor. J. Immunol. 144:740, 1990
27. Hourcade, D., Garcia, A.D., Post, T.W., Taillon Miller, P., Holers, V.M., Wagner, L.M., Bora, N.S., Atkinson, J.P.: Analysis of the human regulators of complement activation (RCA) gene cluster with yeast artificial chromosomes (YACs). Genomics 12:289, 1992
28. Kinoshita, T.: Biology of complement: the overture. Immunol. Today 12:291, 1991
29. Davies, K.A.: Complement. Clin. Haematol. 4:927, 1991
30. Morgan, B.P.: Complement regulatory molecules: application to therapy and transplantation. Immunol. Today 16:257, 1995
31. Morgan, B.P., Meri, S.: The biology of complement: membrane proteins that protect against complement lysis. Springer Semin. Immunopathol. 15:48, 1994
32. White, D.J., Cozzi, E., Langford, G., Oglesby, T., Wang, M.W., Wright, L., Wallwork, J.: Genetic engineering of the donor species to control hyperacute xenograft rejection. Adv. Nephrol. Necker Hosp. 24:331, 1995
33. White, D.J., Cozzi, E., Langford, G., Oglesby, T., Wang, M.W., Wright, L., Wallwork, J.: The control of hyperacute rejection by genetic engineering of the donor species. Eye 9:185, 1995
34. Carrington, C.A., Richards, A.C., Cozzi, E., Langford, G., Yannoutsos, N., White, D.J.: Expression of human DAF and MCP on pig endothelial cells protects from human complement. Transplant. Proc. 27:321, 1995
35. Dalmasso, A.P., Platt, J.L., Bach, F.H.: Reaction of complement with endothelial cells in a model of xenotransplantation. Clin. Exp. Immunol. 86(Suppl. 1):31, 1991
36. Dalmasso, A.P., Vercellotti, G.M., Platt, J.L., Bach, F.H.: Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor: potential for prevention of xenograft hyperacute rejection. Transplantation 52:530, 1991
37. Miyagawa, S., Shirakura, R., Iwata, K., Nakata, S., Matsumiya, G., Izutani, H., Matsuda, H., Terado, A., Matsumoto, M., Nagasawa, S., Seya, T.: Effects of transfected complement regulatory proteins, MCP, DAF, and MCP/DAF hybrid, on complement-mediated swine endothelial cell lysis. Transplantation 58:834, 1994
38. McCurry, K.R., Kooyman, D.L., Diamond, L.E., Byrne, G.W., Logan, J.S., Platt, J.L.: Transgenic expression of human complement regulatory proteins in mice results in diminished complement deposition during organ xenoperfusion. Transplantation 59:1177, 1995
39. Cary, N., Moody, J., Yannoutsos, N., Wallwork, J., White, D.: Tissue expression of human decay accelerating factor, a regulator of complement activation expressed in mice: a potential approach to inhibition of hyperacute xenograft rejection. Transplant. Proc. 25:400, 1993
40. Miyagawa, S., Mikata, S., Shirakura, R., Matsuda, H., Nagasawa, S., Terados, A., Hatanaka, M., Matsumoto, M., Seya, T.: C5b-8 step lysis of swine endothelial cells by human complement and functional feature of transfected CD59. Scand. J. Immunol. 43:361, 1996
41. White, D.: Alteration of complement activity: a strategy for xenotransplantation. Trends Biotechnol. 14:3, 1996
42. White, D.J., Oglesby, T., Liszewski, M.K., Tedja, I., Hourcade, D., Wang, M.W., Wright, L., Wallwork, J., Atkinson, J.P.: Expression of human decay accelerating factor or membrane cofactor protein genes on mouse cells inhibits lysis by human complement. Transplant. Proc. 24:474, 1992
43. White, D., Langford, G., Cozzi, E., Young, V.: Production of pigs transgenic for human DAF: a strategy for xenotransplantation. Xenotransplantation 2:213, 1995
44. Yannoutsos, N., Ijzermans, J.N.M., White, D.: Using yeast artificial chromosomes to generate transgenic animals. Xeno 3:107, 1995
45. Yannoutsos, N., Langford, G.A., Cozzi, E., Lancaster, R., Elsome, K., Chen, P., White, D.J.: Production of pigs transgenic for human regulators of complement activation. Transplant. Proc. 27:324, 1995
46. Brinster, R.L., Allen, J.M., Behringer, R.R., Gelinas, R.E., Palmiter, R.D.: Introns increase transcriptional efficiency in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 85:836, 1988
47. Russell, S.M., Sparrow, R.L., McKenzie, I.F., Purcell, D.F.: Tissue-specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing. Eur. J. Immunol. 22:1513, 1992
48. Rosengard, A., Cary, N., Langford, G., Tucker, A., Wallwork, J., White, D.: Tissue expression on human complement inhibitor, decay-accelerating factor, in transgenic pig. Transplantation 59:1325, 1995
49. Carrington, C.A., Richards, A.C., Tucker, A.W., Peters, A.L., White, D.J.G.: A line of transgenic pigs in which the expression of human decay-accelerating factor by endothelial cells is increased in the presence of inflammatory stimuli. Xenotransplantation 3:87, 1996
50. Vercellotti, G.M., Platt, J.L., Bach, F.H., Dalmasso, A.P.: Neutrophil adhesion to xenogeneic endothelium via iC3b. J. Immunol. 146:730, 1991
51. Fearon, D.T., Collins, B.H.: Increased expression of C3b receptors on polymorphonuclear leukocytes induced by chemotaxic factors and purification procedures. J. Immunol. 130:370, 1983
52. Young, V.: Studies of hyperacute xenograft rejection using an ex vivo model. M.D. Thesis, Trinity College, Cambridge University, 1995
53. Kroshus, T.J., Bolman, R.M., III, Dalmasso, A.P., Rollins, S.A., Guilmette, E.R., Williams, B.L., Squinto, S.P., Fodor, W.L.: Expression of human CD59 in transgenic pig organs enhances organ survival in an ex vivo xenogeneic perfusion model. Transplantation 61:1513, 1996
54. White, D.: hDAF transgenic pig organs: are they concordant for human transplantation. Xeno 4:50, 1996
55. Pruitt, S.K., Kirk, A.D., Bollinger, R.R., Marsh, H.C., Jr., Collins, B.H., Levin, J.L., Mault, J.R., Heinle, J.S., Ibrahim, S., Rudolph, A.R., Baldwin, W.M., III, Sanfilippo, F.P.: The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts. Transplantation 57:363, 1994
56. Platt, J.L., Holzknecht, Z.E., Lindman, B.J.: Porcine endothelial cell antigens recognized by human natural antibodies. Transplant. Proc. 26:1387, 1994
57. Van den Berg, C.W., Morgan, B.P.: Complement-inhibiting activities of human CD59 and analogues from rat, sheep, and pig are not homologously restricted. J. Immunol. 152:4095, 1994
58. Byrne, G.W., McCurry, K.R., Martin, M.J., McClellan, S.M., Platt, J.L., Logan, J.S.: Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage. Transplantation 63:149, 1997