Internal regulation of a modular system: The different faces of internal control

BioSystems

Volumn 44, Issue 2, 1997, Pages 79-106

  Van Der Gugten, Anton A ^a   V Westerhoff, Hans ^b  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Globalization; Hierarchical control; Homeostasis; Metabolic control analysis; Regulation

Indexed keywords

ARTICLE; CELL FUNCTION; CONTROL SYSTEM; HUMAN; METABOLIC REGULATION; NONHUMAN; SIGNAL TRANSDUCTION;

EID: 0030661628     PISSN: 03032647     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-2647(97)00041-5     Document Type: Article

References (46)

1. Acerenza L., Sauro H.M., Kacser H. Control analysis of time-dependent metabolic systems. J. Theor. Biol. 137:1989;423-444.
2. Ayres, F., 1962. Theory and Problems of Matrices. Schaum, New York.
3. Brown G.C., Hafner R.P., Brand M.D. A 'top-down' approach to the determination of control coefficients in metabolic control theory. Eur. J. Biochem. 188:1990;321-325.
4. Burns J.A., Cornish-Bowden A., Groen A.K., Heinrich R., Kacser H., Rapoport S.M., Rapoport T.A., Stucki J.W., Tager J.M., Wanders R.J., Westerhoff H.V. Control analysis of metabolic systems. Trends Biochem. Sci. 10:1985;16.
5. Cascante M., Franco R., Canela E.I. Use of implicit methods from general sensitivity theory to develop a systematic approach to metabolic control. I. Unbranched pathways (review). Math. Biosci. 94:1989;271-288.
6. Cascante M., Franco R., Canela E.I. Use of implicit methods from general sensitivity theory to develop a systematic approach to metabolic control. II. Complex systems (review). Math. Biosci. 94:1989;289-309.
7. Chen Y., Maxwell A., Westerhoff H.V. Co-operativity and enzymatic activity in polymer-activated enzymes. A one-dimensional piggy-back binding model and its application to the DNA-dependent ATPase of DNA gyrase. J. Mol. Biol. 190:1986;201-214.
8. Chen Y.D., Westerhoff H.V. How do inhibitors and modifiers of individual enzymes affect steady-state fluxes and concentrations in metabolic systems? Math. Model. 7:1986;1173-1180.
9. Crabtree B., Newsholme E.A. The derivation and interpretation of control coefficients. Biochem. J. 247:1987;113-120.
10. De Vries H., 1889. Intrazellulaere Pangenesis, Fisher, Jena.
11. Hafner R.P., Nobes C.D., McGown A.D., Brand M.D. Altered relationship between proton motive force and respiration rate in non-phosphorylating liver mitochondria isolated from rats of different thyroid hormone status. Eur. J. Biochem. 178:1988;511-518.
12. Hafner R.P., Brown G.C., Brand M.D. Analysis of the control of respiration rate, phosphorylation rate, proton leak rate and proton motive force in isolated mitochondria using the 'top-down' approach of metabolic control theory. Eur. J. Biochem. 188:1990;313-319.
13. Heinrich R., Rapoport S.M., Rapoport T.A. Metabolic regulation and mathematical models [review]. Prog. Biophys. Mol. Biol. 32:1977;1-82.
14. Hofmeyr, J.-HS., Cornish-Bowden, A., 1993a. A control analysis of metabolic regulation. In: Schuster, S., Rigoulet, M., Duhabi, R., Mazat, J.-P. (Eds.), Modern Trends in Biothermokinetics. Plenum, New York, pp. 193-198.
15. Hofmeyr J.H., Cornish-Bowden A., Rohwer J.M. Taking enzyme kinetics out of control; putting control into regulation. Eur. J. Biochem. 212:1993;833-837.
16. Hofmeyr, J.-HS., Cornish-Bowden A., 1994. How should we quantify metabolic regulation? In: Gnaiger, E., Gellerich, F.N., Wyss, M. (Eds.) What is Controlling Life? Innsbruck University Press, Innsbruck, pp. 91-94.
17. Jensen P.R., Westerhoff H.V., Michelsen O. The use of lac-type promoters in control analysis. Eur. J. Biochem. 211:1993;181-191.
18. Jensen P.R., Westerhoff H.V., Michelsen O. Excess capacity of H(+)-ATPase and inverse respiratory control in Escherichia coli. EMBO J. 12:1993;1277-1282.
19. Jensen P.R., Snoep J.L., Molenaar D., van Heeswijk W.C., Kholodenko B.N., van der Gugten A.A., Westerhoff H.V. Molecular biology for flux control (review). Biochem. Soc. Trans. 23:1995;367-370.
20. +-ATPase in Escherichia coli. J. Bioenerg. Biomembr. 27:1995;543-554.
21. Kacser H., Burns J.A. The control of flux. Symp. Soc. Exp. Biol. 27:1973;65-104.
22. Kacser H. The control of enzyme systems in vivo: elasticity analysis of the steady state. Biochem. Soc. Trans. 11:1983;35-40.
23. Kahn, D., Westerhoff, H.V., 1993a. Regulation and homeostasis in metabolic control theory: interplay between fluctuations of variables and parameter changes. In: Schuster, S., Rigoulet, M., Duhabi, R., Mazat, J.-P. (Eds.), Modern Trends in Biothermokinetics. Plenum, New York, pp. 199-204.
24. Kahn D., Westerhoff H.V. Control theory of regulatory cascades. J. Theor. Biol. 153:1991;255-285.
25. Kahn D., Westerhoff H.V. The regulatory strength: how to be precise about regulation and homeostasis. Acta Biotheor. 41:1993;85-96.
26. Kholodenko B.N., Sauro H.M., Westerhoff H.V. Control by enzymes, coenzymes and conserved moieties. A generalization of the connectivity theorem of metabolic control analysis. Eur. J. Biochem. 225:1994;179-186.
27. Kholodenko B.N., Schuster S., Rohwer J.M., Cascante M., Westerhoff H.V. Composite control of cell function: metabolic pathways behaving as single control units. FEBS Lett. 368:1995;1-4.
28. Reder C. The structural approach to metabolic control analysis I: theoretical aspects. Life Sci. 190:1989;121-127.
29. Reder C. Metabolic control theory: a structural approach. J. Theor. Biol. 135:1988;175-201.
30. Rohwer, J.M., Schuster, S., Westerhoff, H.V., 1994. An invariance property of co-response coefficient in modular control and regulation analysis. In: Gnaiger, E., Gellerich, F.N., Wyss, M. (Eds.), What is Controlling Life. Innsbruck University Press, Innsbruck, pp. 109-110.
31. Rohwer J.M., Schuster S., Westerhoff H.V. How to recognize monovalent units in a metabolic system. J. Theor. Biol. 179:1996;213-228.
32. Savageau, M.A., 1976. Biochemical Systems Analysis: a Study of Function and Design in Molecular Biology. Addison-Wesley, New York.
33. Schuster, S., Kahn, D., Westerhoff, H.V., 1993a. A modular approach to the description of the control of connected metabolic systems. In: Schuster, S., Rigoulet, M., Ouhabi, R., Mazat, J.-P. (Eds.), Modern Trends Biothermokynetics. Plenum Press, New York, pp. 229-235.
34. Schuster S., Schuster R. Decomposition of biochemical reaction systems according to flux control insusceptibility. J. Chem. Phys. 89:1992;1887-1910.
35. Schuster S., Kahn D., Westerhoff H.V. Modular analysis of the control of complex metabolic pathways. Biophys. Chem. 48:1993;1-17.
36. Small J.R., Fell D.A. The matrix method of metabolic control analysis: its validity for complex pathway structures. J. Theor. Biol. 136:1989;181-197.
37. Tager J.M., Groen A.K., Wanders R.J., Duszynski J., Westerhoff H.V., Vervoorn R.C. Control of mitochondrial respiration. Biochem. Soc. Trans. 11:1983;40-43.
38. Van der Gugten, A.A., Westerhoff, H.V., 1993. Internal Regulation. The CE=I=EC square-matrix method illustrated for a simple case of a complex pathway. In: Schuster, S., Rigoulet, M., Ouhabi, R., Mazat, J.-P. (Eds.), Modern Trends in Biothermokynetics, Plenum, New York, pp. 229-235.
39. Westerhoff H.V., Kell D.B. Matrix method for determining steps most rate-limiting to metabolic fluxes in biotechnological processes. Biotechnol. Bioeng. 30:1987;1101-1107.
40. Westerhoff, H.V., Van Dam, K., 1987. Thermo-dynamics and Control of Biological Free-Energy Transduction. Elsevier, Amsterdam.
41. Westerhoff, H.V., Koster, J.G., Van Workum, M., Rudd, K.E., 1990. On the control of gene expression. In: Cornish-Bowden, A., Carnedas, M.L. (Eds.), Control of Metabolic Processes, Plenum, New York, pp. 399-412.
42. Westerhoff, H.V., 1991. Quantification of regulation and control. In: Grunnet, N., Quistorff, B. (Eds.), Regulation of Hepatic Function, Munksgaard, Copenhagen, pp. 232-242.
43. Westerhoff H.V., Chen Y.D. How do enzyme activities control metabolite concentrations? An additional theorem in the theory of metabolic control. Eur. J. Biochem. 142:1984;425-430.
44. Westerhoff H.V., Groen A.K., Wanders R.J. Modern theories of metabolic control and their applications (review). Biosci. Rep. 4:1984;1-22.
45. Westerhoff H.V., Kahn D. Control involving metabolism and gene expression: the square-matrix method for modular decomposition. Acta Biotheor. 41:1993;75-83.
46. Westerhoff H.V., Hofmeyr J.H., Kholodenko B.N. Getting to the inside of cells using metabolic control analysis. Biophys. Chem. 50:1994;273-283.