Pinaverium acts as L-type calcium channel blocker on smooth muscle of colon

Canadian Journal of Physiology and Pharmacology

Volumn 75, Issue 8, 1997, Pages 969-975

  Malysz, John ^a   Farraway, Laura A ^a   Christen, Marie Odile ^b   Huizinga, Jan D ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b Solvay Pharma   (France)

Author keywords

Irritable bowel syndrome; Motility; Pacemaker activity; Pinaverium; Smooth muscle

Indexed keywords

ATROPINE; CALCIUM CHANNEL BLOCKING AGENT; CARBACHOL; DILTIAZEM; GALLOPAMIL; NITRENDIPINE; PINAVERIUM;

ANIMAL TISSUE; ARTICLE; CHOLINERGIC ACTIVITY; COLON; CONTROLLED STUDY; DOG; ELECTROPHYSIOLOGY; ELECTROSTIMULATION; FEMALE; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION;

EID: 0030660644     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y97-117     Document Type: Article

References (4)

1. Abe, Y., and Tomita, T. 1968. Cable properties of smooth muscle. J. Physiol. (London), 196: 87-100.
2. Bailey, L.D., Jr., Stewart, W.R., Jr., and McCallum, R.W. 1991. New directions in the irritable bowel syndrome. [Review]. Gastroenterol. Clin. North Am. 20: 335-349.
3. Barajas-López, C., and Huizinga, J.D. 1989. Different mechanisms of contraction generation in circular muscle of canine colon. Am. J. Physiol. 256: G570-G580.
4. Baumgartner, A., Drack, E., Halter, F., and Scheurer, U. 1985. Effects of pinaverium bromide and verapamil on the motility of the rat isolated colon. Br. J. Pharmacol. 86: 89-94.