Synthesis of (+)- and (-)-2-methylarachidonyl-2'-fluoroethylamide (O-689)

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 20, 1997, Pages 2669-2672

  Ryan, William J ^a   Banner, W Kenneth ^a   Crocker, Peter J ^a   Martin, Billy R ^b   Razdan, Raj K ^a  

^a ORGANIX INC   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLARACHIDONYL 2' FLUOROETHYLAMIDE; ARACHIDONIC ACID DERIVATIVE; CANNABINOID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENANTIOMER; LOCOMOTION; MOUSE; NONHUMAN; STEREOCHEMISTRY; TAIL FLICK TEST;

EID: 0030660479     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10047-6     Document Type: Article

References (21)

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18. Unpublished observation from our laboratory.
19. 3) δ 0.89 (t, J = 6.6 Hz, 3H), 1.16 (d, J = 6.8 Hz, 3H), 1.25-1.40 (m, 6H), 1.42-1.89 (m, 2H), 1.93-2.34 (m, 5H), 2.75-2.92 (m, 6H), 3.56 (ddt, J = 28.0, 5.1, 4.5 Hz, 2H), 4.47 (dt, J = 52.4, 4.9 Hz, 2H), 5.20-5.65 (m, 8H), 5.84 (br s, 1H); Anal. C, H, N.
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21. 1H NMR to 2a except the coupling constant of the doublet of doublets at δ 3.87 was J = <1.0, and 4.6 Hz.