Rilmenidine in rosacea: A double-blind study versus placebo;Rilmenidine dans la rosacee: Etude en double insu contre placebo

Annales de Dermatologie et de Venereologie

Volumn 124, Issue 10, 1997, Pages 687-691

  Grosshans, E ^a   Michel, C ^a   Arcade, B ^b   Cribier, B ^a,c  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^c UNIVERSITY HOSPITAL OF STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; CLONIDINE; IMIDAZOLINE RECEPTOR; METRONIDAZOLE; PLACEBO; RILMENIDINE; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; OXAZOLE DERIVATIVE;

ARTHRALGIA; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; DYSPNEA; HEADACHE; HEART PALPITATION; HOT FLUSH; HUMAN; NAUSEA; PUSTULE; RANDOMIZED CONTROLLED TRIAL; ROSACEA; XEROSTOMIA; ADULT; DRUG TOLERANCE; FEMALE; FLUSHING; MALE; MIDDLE AGED; TREATMENT OUTCOME;

ADRENERGIC ALPHA-AGONISTS; ADULT; DOUBLE-BLIND METHOD; DRUG TOLERANCE; FEMALE; FLUSHING; HUMANS; MALE; MIDDLE AGED; OXAZOLES; PLACEBOS; ROSACEA; TREATMENT OUTCOME;

EID: 0030660474     PISSN: 01519638     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Berg M., Liden S. An epidemiological study for rosacea. Acta Derm Venereol (Stockh), 1989;69:419-23.
2. Grosshans E. La rosacée. Presse Med, 1988;17:2393-8.
3. Brinnel H., Friedel J., Caputa M., Cabanac M., Grosshans E. Rosacea: disturbed defence against brain overheating. Arch Dermatol Res, 1989;281:66-72.
4. Knight A.G., Vickers C.F.H. A follow-up of tetracycline-treated rosacea with special references to rosacea keratitis. Br J Dermatol, 1975;93:577-80.
5. Aronson I.K., Rumsfield J.A., West D.P., Alexander J., Fischer J.H. Evaluation of topical metronidazole gel in acne rosacea. Drug Intell Clin Pharm, 1987;21:346-51.
6. Bleicher P.A., Charles J.H., Sober A.J. Topical metronidazole therapy for rosacea. Arch Dermatol, 1987;123:609-14.
7. Gamborg Nielsen P. A double blind study of 1 % metronidazole cream versus oxytctracycline therapy for rosacea. Br J Dermatol, 1983;109:63-5.
8. Espagne E., Guillaume J.C., Archimbaud A., Baspeyras M., Boitier F., Bussière M. et coll. Etude en double insu contre excipient du métronidazole gel à 0.75 % dans le traitement de la rosacée. Ann Dermatol Venereol, 1993;120:129-33.
9. Wilkin J.K. Effect of subdepressor clonidine on flushing reactions in rosacea. Arch Dermatol, 1983;119:211-4.
10. Cunliffe J.W., Dobman B., Binner J.G. Clonidine and facial flushing in rosacea. Br Med J, 1977;1:105.
11. Bousquet P., Feldman J., Bloch R., Schwartz P. The nucleus reticularis lateralis a region highly sensitive to clonidine. Eur J Pharmacol, 1981;69:389-92.
12. Bricca G., Dontenwill M., Molines A., Feldman J., Tibrica E., Belcourt A. et coll. Rilmenidine selectivity for imidazoline receptors in human brain. Eur J Pharmacol, 1989;163:373-7.
13. Feldman J., Tibirica E., Bricca G., Dontenwill M., Belcourt A., Bousquet P. Evidence for the involvement of imidazoline receptors in the central hypotensive effect of rilmenidine in the rabbit. Br J Pharmacol, 1990;100:600-4.
14. Pye R.J., Burton J.L. Treatment of rosacea by metronidazole. Lancet, 1976;i:1211-2.
15. Gamborg Nielsen P. Treatment of rosacea with 1 % metronidazole cream: a double blind study. Br J Dermatol 1983;108:327-32.
16. Sneddon I.B. A clinical trial of tetracycline in rosacea. Br J Dermatol, 1966;78:649-652.
17. Parodi A., Guarrera M., Rebora A. Flushing in rosacea: an experimental approach. Arch Dermatol Res, 1980;269:269-73.
18. Guarrera M., Parodi A., Cipriani C., Divano C., Rebora A. Flushing in rosacea: a possible mechanism. Arch Dermatol Res, 1982;272:311-6.
19. Ostermann G., Brisgand B., Schmitt J., Fillastre J.P. Efficacy and acceptability of rilmenidine for mild to moderate hypertension. Am J Cardiol, 1988;61:76D-80D.