Current and emerging treatments for pancreatic cancer

Drugs and Aging

Volumn 11, Issue 4, 1997, Pages 285-295

  Regine, William F ^a   John, William J ^b   Mohiuddin, Mohammed ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; GEMCITABINE; IODINE 125; OCTREOTIDE; PEMETREXED; RADIOISOTOPE; RADIOSENSITIZING AGENT; RALTITREXED; TAMOXIFEN;

ADVANCED CANCER; BONE MARROW SUPPRESSION; CANCER ADJUVANT THERAPY; CANCER INCIDENCE; CANCER MORTALITY; CANCER SURGERY; CANCER SURVIVAL; CLINICAL TRIAL; DRUG IMPLANT; DRUG TOXICITY; FEASIBILITY STUDY; FEVER; HAIR LOSS; HEPATITIS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; METASTASIS; MORBIDITY; MOUTH MUCOSA; MUCOSA INFLAMMATION; NAUSEA; PANCREAS CANCER; PANCREATICODUODENECTOMY; PRIORITY JOURNAL; RASH; REVIEW; TREATMENT OUTCOME; VOMITING;

EID: 0030659648     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-199711040-00004     Document Type: Review

References (77)

1. Parker SL, Tong T, Bolden S, et al. Cancer statistics. 1997. CA Cancer J Clin 1997; 47: 5-27
2. Parkin D, Pisani P, Ferlay J. Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer 1993; 54: 594-606
3. Douglass H. Adjuvant therapy for pancreatic cancer. World J Surg 1995; 19: 170-4
4. Shibamoto Y, Manabe T, Baba M, et al. High dose, external beam and intraoperative radiotherapy in the treatment of resectable pancreatic cancer. Int J Radiat Oncol Biol Phys 1990; 19: 605-11
5. American Cancer Society. Cancer facts and figures: 1991. Atlanta: American Cancer Society, 1991
6. Connolly M, Dawson P, Michelassi F, et al. Survival in 1001 patients with carcinoma of the pancreas. Ann Surg 1987; 206: 366-73
7. Singh S, Longmire W, Reber H. Surgical palliation for pancreatic cancer: the UCLA experience. Ann Surg 1990; 212: 132-9
8. Rosenberg JM, Welch JP, Macaulay WP. Cancer of the head of the pancreas: an institutional review with emphasis on surgical therapy. J Surg Oncol 1985; 28: 217-21
9. Tsuchiya R, Noda T, Harada M, et al. Collective review of small carcinomas of the pancreas. Ann Surg 1986; 203: 77-81
10. Funovics JM, Karner J, Pratschner T, et al. Current trends in the management of carcinoma of the pancreatic head. Hepatogastroenterology 1989; 36: 450-5
11. Nitecki SS, Sarr MG, Colby TV, et al. Long-term survival after resection for ductal adenocarcinoma of the pancreas: is it really improving? Ann Surg 1995; 221 (1): 59-66
12. Piorkowski RJ, Believernicht SW, Lawrence Jr W, et al. Pancreatic and periampullary carcinoma: experience with 200 patients over a 12-year period. Am J Surg 1982; 143: 189-93
13. Gudjonsson B. Cancer of the pancreas: 50 years of surgery. Cancer 1987; 60: 2284-303
14. Geer RJ, Brennan MF. Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am J Surg 1993; 165: 68-73
15. Trede M, Chir B, Schwall G, et al. Survival after pancreatoduodenectomy. Ann Surg 1990; 21 (4):447-58
16. Yeo CJ, Cameron JL, Lillemoe KD, et al. Pancreaticoduodenectomy for cancer of the head of the pancreas: two hundred and one patients. Ann Surg 1995; 221 (6): 721-33
17. Gastrointestinal Tumor Study Group. Therapy of locally unresected pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads) + 5-fluorouracil, and high dose radiation + 5-fluorouracil. Cancer 1981; 48: 1705-10
18. Whittington R, Bryer MP, Haller DG, et al. Adjuvant therapy of resected adenocarcinoma of the pancreas. Int J Radiat Oncol Biol Phys 1991; 21: 1137-43
19. Tepper J, Nardi G, Suit H. Carcinoma of the pancreas: review of MGH experience from 1963 to 1973 - analysis of surgical failure and implications for radiation therapy. Cancer 1976; 37: 1519-24
20. Kalser MH, Ellenberg SS. Pancreatic cancer: adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 1985; 12: 899-903
21. Douglass HO, Strablein DM. Ten year follow-up of first generation surgical adjuvant studies of the Gastrointestinal Tumor Study Group. In: Salmon SE, editor. Adjuvant therapy of cancer IV. Philadelphia: W.B. Saunders, 1990: 405-15
22. Gastrointestinal Tumor Study Group. Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Cancer 1987; 59: 2006-10
23. Foo ML, Gunderson LL, Nagorney DM, et al. Patterns of failure in grossly resected pancreatic ductal adenocarcinoma treated with adjuvant irradiation + 5-fluorouracil. Int J Radiat Oncol Biol Phys 1993; 26: 483-9
24. Yeo CJ, Hruban RH, Kern SE, et al. Adenocarcinoma of the pancreas: factors influencing outcome after pancreaticoduodenectomy - the Johns Hopkins experience. Cancer Bull 1994; 46(6): 504-10
25. Spitz FR, Abbruzzese JL, Lee JE, et al. Preoperative and post-operative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas. J Clin Oncol 1997; 15(3): 928-37
26. Mohiuddin M, Rosato F, Schuricht A, et al. Carcinoma of the pancreas - the Jefferson experience 1975-1988. Eur J Surg Oncol 1994; 20: 13-20
27. O'Connell MJ, Martenson JA, Wieand HS, et al. Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med 1994; 331 (8): 502-7
28. Whittington R, Neuberg D, Tester WJ, et al. Protracted intravenous fluorouracil infusion with radiation therapy management of localized pancreaticobiliary carcinoma: a phase I Eastern Cooperative Group trial. J Clin Oncol 1995; 13 (1): 227-32
29. Pilepich MV, Miller HH. Preoperative irradiation in carcinoma of the pancreas. Cancer 1980; 46: 1945-9
30. Kopelson G. Curative surgery for adenocarcinoma of the pancreas/ampulla of Vater: the role of adjuvant pre- or postoperative radiation therapy. Int J Radial Oncol Biol Phys 1983; 9: 911-5
31. Evans DB, Rich TA, Byrd DR, et al. Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas. Arch Surg 1992; 127: 1335-9
32. Coia L, Hoffman J, Scher R, et al. Preoperative chemoradiation for adenocarcinoma of the pancreas and duodenum. Int Radiat J Oncol Biol Phys 1994; 30 (1): 161-7
33. Hoffman JP, Weese JL, Lipsitz S, et al. Preoperative chemoradiation for patients with resectable pancreatic adenocarcinoma: an Eastern Cooperative Group (ECOG) phase II study [abstract]. Proc Am Soc Clin Oncol 1995; 14: 201
34. Fuhrman GM, Charnsangavej C, Abbruzzese JL, et al. Thin-section contrast-enhanced computed tomography accurately prediets the resectability of malignant pancreatic neoplasms. Am J Surg 1994; 167: 104-13
35. Nagakawa T, Konishi I, Ueno K, et al. The results and problems of extensive surgery for carcinoma of the head of the pancreas. Jpn J Surg 1991; 21: 262-7
36. Todd KE, Gloor B, Lane JS, et al. Resection of locally advanced pancreatic cancer after downstaging with continuous infusion 5-FU, mitomycin-C, leucovorin (LV) and persantine. Gastroenterology 1997; 112 Suppl. 4: A1479
37. Lillemoe KD, Cameron JL, Yeo CJ, et al. Pancreaticoduodenectomy: does it have a role in the palliation of pancreatic cancer? Ann Surg 1996; 223 (6): 718-28
38. Moertel CG. Chemotherapy of gastrointestinal cancer. N Engl J Med 1978; 299: 1049-52
39. Smith FP, Schein PS. Chemotherapy of pancreatic cancer. Semin Oncol 1979; 6 (3): 368-77
40. Cullinan SA, Moertel CG, Fleming TR, et al., and the North Central Cancer Treatment Group. A comparison of three chemotherapeutic regimens in the treatment of advanced pancreatic and gastric carcinoma. JAMA 1985; 253: 2061-7
41. Gunderson LL, Martin JK, Kvols LK, et al. Intraoperative and external beam irradiation ± 5-FU for locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 1987; 13: 319-29
42. Dobelbower RR, Borgelt BB, Strubler KA, et al. Precision radiotherapy for cancer of the pancreas: technique and results. Int J Radiat Oncol Biol Phys 1980; 6: 1127-34
43. Flickinger JC, Jawalekar K, Deutsch M, et al. Split course radiation therapy for adenocarcinoma of the pancreas. Int J Radiat Oncol Biol Phys 1988; 15: 359-64
44. Haslam JB, Cavanaugh PJ, Stroup SL. Radiation therapy in the treatment of irresectable adenocarcinoma of the pancreas Cancer 1973; 32: 1341-5
45. Gastrointestinal Tumor Study Group. Comparative therapeutic trial of radiation with or without chemotherapy in pancreatic carcinoma. Int J Radial Oncol Biol Phys 1979; 5: 1643-7
46. Gastrointestinal Tumor Study Group. Treatment of locally unresectable carcinoma of the pancreas: comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. J Natl Cancer Inst 1988; 80: 751-5
47. Moertel CG, Childs Jr DS, Reitemeir RJ, et al. Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet 1969; 11: 865-7
48. Whittington K, Dobelbower RR, Mohiuddin M, et al. Radiotherapy of unresectable pancreatic carcinoma: a six year experience with 104 patients. Int J Radial Oncol Biol Phys 1981; 7: 1639-44
49. Shipley WU, Nardi GL, Cohen AM, et al. Iodine-125 implant and external beam irradiation in patients with localized pancreatic carcinoma of the pancreas with 1-125 implantation. Cancer 1980; 45: 709-14
50. Peretz T, Nori D, Hilaris B, et al. Treatment of primary unresectable carcinoma of the pancreas with 1-125 implantation. Int J Radiat Oncol Biol Phys 1989; 17: 931-5
51. Mohiuddin M, Cantor RJ, Biermann W, et al. Combined modality treatment of localized unresectable adenocarcinoma of the pancreas. Int J Radiat Oncol Biol Phys 1988; 148: 79-84
52. Mohiuddin M, Rosato F, Burbot D, et al. Long-term results of combined modality treatment with I-125 implantation for carcinoma of the pancreas. Int J Radiat Oncol Biol Phys 1992; 23: 305-11
53. Mohiuddin M, Regine WF, Rosato F, et al. A comparison of intraoperative radiation therapy (IORT) and I-125 implantation for cancer of the pancreas. In: Schildberg FW, Willich N, Kramling H-J, editors. Proceedings of the 4th International Symposium on Intraoperative Radiation Therapy: Munich: 1992. Essen: 315-23
54. Kaul R, Cohen L, Hendrickson F, et al. Pancreatic carcinoma: results with fast neutron therapy. Int J Radial Oncol Biol Phys 1981; 7: 173-8
55. Cohen L, Woodruff KH, Hendrickson FR, et al. Response of pancreatic cancel to local irradiation with high-energy neutrons. Cancer 1985; 56: 1235-41
56. Castro JR, Saunders WM, Quivey JM, et al. Clinical problems in radiotherapy of carcinoma of the pancreas. Am J Clin Oncol 1982; 5: 579-87
57. Levin PL, Connely RR, DeVesa SS. Demographic characteristics of cancer of the pancreas: mortality, incidence, and survival. Cancer 1981; 47: 1456-68
58. Shapiro TM. Adenocarcinoma of the pancreas: a statistical analysis of biliary bypass vs. Whipple resection in good risk patients. Ann Surg 1975; 182: 715-21
59. Shipley WU, Wood WC, Tepper JE, et al. Intraoperative electron beam irradiation for patients with unresectable pancreatic carcinoma. Ann Surg 1984; 200: 289-96
60. Roldan GE, Gunderson LL, Nagorney DM, et al. External beam versus intraoperative and external beam irradiation for locally advanced pancreatic cancer. Cancer 1988; 61: 1110-6
61. Tepper JE, Noyes D, Krall JM, et al. Intraoperative radiation therapy of pancreatic carcinoma: a report of RTOG-8505. Int J Radiat Oncol Biol Phys 1991; 21: 1145-9
62. Hall EJ, Brenner DJ. Radiobiology of radiosurgery: rationale for different treatment regimes for AVMs and malignancies. Int J Radiat Oncol Biol Phys 1993; 25: 381-5
63. Safran H, King TP, Choy H, et al. Paclitaxel and concurrent radiation for locally advanced pancreatic and gastric cancer: a phase I study. J Clin Oncol 1997; 15 (3): 901-7
64. Burris HA, Moore MJ, Anderson J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997; 15 (6): 2403-13
65. Rothenberg ML, Moore MJ, Cripps MC, et al. A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer. Ann Oncol 1996; 7: 347-53
66. Miller KM, Picus J, Lochner P, et al. A phase II trial of LY231514 in patients with unresectable pancreas cancer. Proc Am Soc Clin Oncol 1997; 16: 297
67. Wong A, Chan A. Survival benefit of tamoxifen therapy in adenocarcinoma of pancreas: a case-control study. Cancer 1993; 71: 2200-3
68. Rosenberg L, Barkun AN, Denis MH, et al. Low dose octreotide and tamoxifen in the treatment of adenocarcinoma of the pancreas. Cancer 1995; 75: 23-8
69. Burch PA, Block M, Wieand HS, et al. A phase III evaluation of octreotide (somatostatin) versus chemotherapy with 5-FU or 5-FU leucovorin in advance exocrine pancreatic cancer: a NCCTG study [abstract 488]. Proc Am Soc Clin Oncol 1995; 14: 203
70. Buchler M, Sulkowski U, Pederzoli P, et al. A phase II study of octreotide (SMS) in advanced pancreatic cancer [abstract 642]. Proc Am Soc Clin Oncol 1994; 14: 215
71. Cascinu S, Del Ferro E, Catalano G. A randomized trial of octreotide versus best supportive care in advanced gastrointestinal cancer patients refractory to chemotherapy. Br J Cancer 1995; 71: 97-101
72. Weckbecker G, Stolz B, Raulf F, et al. Cyclooctapeptide analogs of somatostatin for the treatment and scintigraphic localization of tumors. Proc Am Assoc Cancer Res 1994; 35: 381
73. Hoshi T, Imai M, Ogawu K. Frequent K-ras mutations and absence of p53 mutations in mucin-producing tumors of the pancreas. J Surg Oncol 1994; 55: 84-91
74. Caldas C, Hahn SA, Hruban RH, et al. Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia. Cancer Res 1994; 54: 3568-73
75. Mohiuddin M, Ahmed MM, Venkatasubbarao K. c-Ki-ras mutations in peripheral blood of pancreatic cancer patients: a marker for early tumor metastasis. Int J Radiat Oncol Biol Phys 1996; 34(1): 161-6
76. Aoki K, Yoshida T, Sugimura T, et al. Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity. Cancer Res 1995; 55: 3810-6
77. Mohiuddin M, Regine WF, Stevens J, et al. Combined intraoperative radiation and perioperative chemotherapy for unresectable cancers of the pancreas. J Clin Oncol 1995; 13(11): 2764-8