Bisphosphonate tiludronate increases bone strength by improving mass and structure in established osteopenia after ovariectomy in rats

Bone

Volumn 21, Issue 4, 1997, Pages 335-343

  Ohnishi, H ^a   Nakamura, T ^a   Narusawa, K ^a   Murakami, H ^b   Abe, M ^b   Barbier, A ^c   Suzuki, K ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b MEIJI SEIKA KAISHA LTD   (Japan)

^c SANOFI   (France)

Author keywords

Femur; Histomorphometry; Lumbar vertebra; Mechanical properties; Osteocalcin; Ovariectomy

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CALCITRIOL; OSTEOCALCIN; PARATHYROID HORMONE; TILUDRONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE BOWING; BONE DENSITY; BONE MASS; BONE MINERAL; BONE STRENGTH; BONE STRUCTURE; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; CORTICAL BONE; FEMALE; FEMUR; MORPHOMETRICS; NONHUMAN; ORAL DRUG ADMINISTRATION; OSTEOPENIA; OVARIECTOMY; PARATHYROID HORMONE BLOOD LEVEL; PROTEIN BLOOD LEVEL; RAT; TRABECULAR BONE;

ANIMALS; BIOMECHANICS; BODY WEIGHT; BONE DENSITY; CALCITONIN; CALCITRIOL; DIPHOSPHONATES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FEMUR; LUMBAR VERTEBRAE; OSTEOCALCIN; OSTEOPOROSIS; OVARIECTOMY; PARATHYROID HORMONE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030659613     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(97)00145-2     Document Type: Article

References (38)

1. Ammann, P., Rizzoli, R., Caverzasio, J., Shigematsu, T., Slosman, D., and Bonjour, J. P. Effects of the bisphosphonate tiludronate on bone resorption, calcium balance, and bone mineral density. J Bone Miner Res 8:1491-1498; 1993.
2. Bagi, C., Van der Meulen M., Brommage, R., Rosen, D., and Sommer, A. The effect of systemically administered rhlGF-1/1GFBP-3 complex on cortical bone strength and structure in ovariectomized rats. Bone 16:559-565; 1995.
3. Barbier, A., Bonjour, P., Geusens, M. C., Vernejoul, D., And Lacheretz, F. Tiludronate: A bisphosphonate with a positive effect on bone quality in experimental models. J Bone Miner Res 6(Suppl):S217; 1991.
4. Barbier, A., Emonds-Alt, X., Breliere, J. C., and Ronucci, R. In vitro and in vivo osseous pharmacological profile of tiludronate. Implications for osteoporosis treatment. In Christiansen, C. and Overgaard, K., Eds. Osteoporosis. Copenhagen: Osteopress; 1990; 1127-1130.
5. Barengolts, E. I., Curry, D. J., Bapna, M. S., and Kukreja, S. C. Effects of endurance exercise on bone mass and mechanical properties in intact and ovariectomized rats. J Bone Miner Res 8:937-942; 1993.
6. 2D in response to inhibition of bone resorption. Am J Physiol 110:E260-E264; 1988.
7. Danielsen, C. C., Mosekilde, L., and Svenstrup, B. Cortical bone mass, composition, and mechanical properties in female rats in relation to age, long-term ovariectomy, and estrogen substitution. Calcif Tissue Int 52:26-33; 1993.
8. Delmas, P. D., Stenner, D., Wahner, H. W., Mann, K. G., and Riggs, B. L. Increase in serum bone gamma-carboxyglutamic acid protein with aging in women. Implications for the mechanism of age-related bone loss. J Clin Invest 71:1316-1321; 1983.
9. Eastell, R., Delmas, P. D., Hodgson, S. F., Eriksen, E. F., Mann, K. G., and Riggs, B. L. Bone formation rate in older normal women: Concurrent assessment with bone histomorphometry, calcium kinetics, and biochemical markers. J Clin Endocrinol Metab 67:741-748; 1988.
10. Garnero, P., Shih, W. J., Gineyts, E., Karpf, D. B., and Delmas, P. D. Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment. J Clin Endocrinol Metab 79:1693-1700; 1994.
11. Geusens, P., Nijs, J., Van der Perre, G., Van Audekercke R., Lowet, G., Goovaerts, S., Barbier, A., Lacheretz, F., Remandet, B., Jiang, Y., et al. Longitudinal effect of tiludronate on bone mineral density, resonant frequency, and strength in monkeys. J Bone Miner Res 7:599-609; 1992.
12. Ismail, F., Epstein, S., Fallon, M. D., Thomas, S. B., and Reinhardt, T. A. Serum bone gla protein and the vitamin D endocrine system in the oophorectomized rat. Endocrinology 122:624-630; 1988.
13. Kalu, D. N. The ovariectomized rat model of postmenopausal bone loss. Bone Miner 15:175-191; 1991.
14. Kalu, D. N., Echon, R., and Hollis, B. W. Modulation of ovariectomy-related bone loss by parathyroid hormone in rats. Mech Ageing Dev 56:49-62; 1990.
15. Lindgren, U. and DeLuca, H. F. Role of parathyroid hormone and 1,25-dihydroxyvitamin D3 in the development of osteopenia in oophorectomized rats. Calcif Tissue Int 34:510-514; 1982.
16. Mosekilde, L., Danielsen, C. C., and Gasser, J. The effect on vertebral bone mass and strength of long term treatment with antiresorptive agents (estrogen and calcitonin), human parathyroid hormone-(1-38), and combination therapy, assessed in aged ovariectomized rats. Endocrinology 134:2126-2134; 1994.
17. Mosekilde, L., Danielsen, C. C., and Knudsen, U. B. The effect of aging and ovariectomy on the vertebral bone mass and biomechanical properties of mature rats. Bone 14:1-6; 1993.
18. Motoie, H., Nakamura, T., O'uchi, N., Nishikawa, H., Kanoh, H., Abe, T., and Kawashima, H. Effects of bisphosphonate YM175 on bone mineral density, strength, structure, and turnover in ovariectomized beagles on concomitant dietary calcium restriction. J Bone Miner Res 10:910-920; 1995.
19. Nagao, Y., Ishitobi, Y., Kinoshita, H., Fukushima, S., and Kawashima, H. YM175, a new bisphosphonate, increases serum 1,25-dihydroxyvitamin D in rats via stimulating renal 1-hydroxylase activity. Biochem Biophys Res Commun 180:1172-1178; 1991.
20. 2D3. Calcif Tissue Int 50:74-79; 1992.
21. 2D3. Bone 10:117-123; 1989.
22. Parfitt, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. A., Malluche, H., Meunier, P. J., Ott, S. M., and Recker, R. R. Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2:595-610; 1987.
23. Parfitt, A. M., Mathews, C. H., Villanueva, A. R., Kleerekoper, M., Frame, B., and Rao, D. S. Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest 72:1396-1409; 1983.
24. Parfitt, A. M., Villanueva, A. R., Feldes, J., and Rao, D. S. Relations between histologic indices of bone formation: Implications for the pathogenesis of spinal osteoporosis. J Bone Miner Res 10:466-473; 1995.
25. Peck, W. A., Burckhardt, P., Christiansen, C., Fleisch, H. A., Genant, H. K., Gennari, C., Martini, L., Morita, R., Ogata, E., Rapado, A., Shulman, L. E., Stein, P. H., and Young, R. I. T. Consensus Development Conference: Diagnosis, Prophylaxis, and Treatment of Osteoporosis. 27 March to 2 April, Hong Kong, 1993.
26. Reginster, J. Y., Lecart, M. P., Deroisy, R., Sarlet, N., Denis, D., Ethgen, D., Collette, J., and Franchimont, P. Prevention of postmenopausal bone loss by tiludronate. Lancet ii:1469-1471; 1989.
27. Rockoff, S. D., Sweet, E., and Bleustein, J. The relative contribution of trabecular and cortical bone to the strength of human lumbar vertebrae. Calcif Tissue Res 3:163-175; 1969.
28. Slootweg, M. C., Van Buul Offers, S., Herrmann, E. M., Van der Meer, J., and Duursma, S. A. Growth hormone is mitogenic for fetal mouse osteoblasts but not for undifferentiated bone cells. J Endocrinol 116: 1988.
29. 3 on alkaline phosphatase and bone GLA-protein of rat osteoblastic cells. Endocrinology 118:1340-1346; 1986.
30. Stepan, J. J., Pospichal, J., Presl, J., and Pacovsky, V. Bone loss and biochemical indices of bone remodeling in surgically induced postmenopausal women. Bone 8:279-284; 1987.
31. Toolan, B. C., Shea, M., Myers, E. R., Borchers, R. E., Seedor, J. G., Quartuccio, H., Rodan, G., and Hayes, W. C. Effects of 4-amino-1-hydroxybutylidene bisphosphonate on bone biomechanics in rats. J Bone Miner Res 7:1399-1406; 1992.
32. Turner, R. T. Cancellous bone turnover in growing rats: Time-dependent changes in association between calcein label and osteoblasts. J Bone Miner Res 9:1419-1424; 1994.
33. Turner, R. T., Wakley, G. K., Hannon, K. S., and Bell, N. H. Tamoxifen prevents the skeletal effects of ovarian hormone deficiency in rats. J Bone Miner Res 2:449-456; 1987.
34. Uzawa, T., Hori, M., Ejiri, S., and Ozawa, H. Comparison of the effects of intermittent and continuous administration of human parathyroid hormone(1-34) on rat bone. Bone 16:477-484; 1995.
35. Wronski, T. J., Dann, L. M., Scott, K. S. , and Cintron, M. Long-term effects of ovariectomy and aging on the rat skeleton. Calcif Tissue Int 45:360-366; 1989
36. Wronski, T. J. and Yen, C. F. Anabolic effects of parathyroid hormone on cortical bone in ovariectomized rats. Bone 15:51-58; 1994.
37. 3 administration in beagles. Calcif Tissue Int 52:49-56; 1993.
38. Yamaura, M., Nakamura, T., Tsurukami, H., Narusawa, K., Ohnishi, H., Ohta, T., Hosoda, K., and Suzuki, K. Local bone turnover in the metaphysis of the proximal and the lumbar vertebra during the early periods after ovariectomy in rats. Calcif Tissue Int 58:52-59; 1996.