Deletions of chromosome 21 restricted to the leukemic cells of children with Down syndrome and leukemia

Leukemia

Volumn 11, Issue 11, 1997, Pages 1973-1977

  Kempski, H M ^a   Chessells, J M ^b   Reeves, B R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GREAT ORMOND STREET HOSPITAL   (United Kingdom)

Author keywords

Chromosome 21 deletions; Down syndrome; Leukemia

Indexed keywords

ARTICLE; CHROMOSOME 21; CHROMOSOME 21Q; CHROMOSOME ARM; CHROMOSOME DELETION; CLINICAL ARTICLE; DISEASE PREDISPOSITION; DOWN SYNDROME; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; IMMUNOPHENOTYPING; LEUKEMIA CELL; MALE; METAPHASE; PRESCHOOL CHILD; PRIORITY JOURNAL;

EID: 0030659475     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400826     Document Type: Article

References (16)

1. Fong C, Brodeur CM. Down's syndrome and leukemia: epidemiology, genetics, cytogenetics and mechanisms of leukemogenesis. Cancer Genet Cytogenet 1987; 28: 55-76.
2. Pui C-H, Raimondi SC, Borowitz MJ, Land VL, Behm FG, Pullen DG, Hancock ML, Shuster JJ, Steuber CP, Crist WM, Civin CI, Carroll AJ. Immunophenotypes and karyotypes of leukemic cells in children with Down syndrome and acute lymphoblastic leukemia. J Clin Oncol 1993; 11: 1361-1367.
3. Avet-Loiseau H, Mechinaud F, Harousseau J-L. Clonal hematologic disorders in Down syndrome. A review. J Pediatr Hematol Oncol 1995; 17: 19-24.
4. ISCN (1995). An International System for Human Cytogenetic Nomenclature. Mitelman F (ed). S Karger: Basel, 1995.
5. Patterson D. Report of the second international workshop on human chromosome 21 mapping. Cytogenet Cell Genet 1991 ; 57: 168-174.
6. Tighe JE, Daga A, Calabi F. Translocation breakpoints are clustered on both chromosome 8 and chromosome 21 in the t(8;21) of acute myeloid leukemia. Blood 1993; 254: 592-596.
7. Solomon E, Borrow J, Goddard AD. Chromosome aberrations and cancer. Science 1991; 254: 1153-1160.
8. Rogan PK, Close P, Bovin J-L, Siep JR, Gannutz L, Ladda RL, Antonarakis SE. Duplication and loss of chromosome 21 in two children with Down syndrome and acute leukemia. Am J Hum Med Genet 1995; 59: 174-181.
9. Shimizu N, Antonarakis SE, Van Broeckhoven C, Patterson D, Gardiner K, Nizetic D, Creau N, Delabar J-M, Korenberg J, Reeves R, Doering J, Chakravati A, Minoshima S, Ritter O, Cuticchia J. Report of the fifth international workshop on human chromosome 21 mapping 1994. Cytogenet Cell Genet 1995; 70: 147-182.
10. Korenberg JR, Chen X-N, Schipper R, Sun Z, Gonsky R, Gerwehr S, Carpenter N, Daumer C, Dignan P, Disteche C, Graham JM, Hugdins L, McGillivray B, Miyazaki K, Ogasawara N, Park JP, Pagon R, Pueschel S, Sack G, Say B, Schuffenhauer S, Soukup S, Yamanaka T. Down syndrome phenotypes: the consequences of chromosomal inbalance. Proc Natl Acad Sci USA 1994; 91: 4997-5001.
11. Erickson P, Gao J, Chang K, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley J, Drabkin H. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript AML1/ETO, with similarity to Drosophila segmentation gene runt. Blood 1992; 80: 1825-1831.
12. Nisson P, Watkins P, Sacchi N. Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells. Cancer Genet Cytogene 1992; 63: 81-89.
13. Nucifora G, Begy CR, Kobayashi H, Roulston D, Claxton D, Pederson-Bjergaard J, Parganas E, Ihle JN, Rowley JD. Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations. Proc Natl Acad Sci USA 1994; 91: 4004-4008.
14. Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, BrayWard P, Morgan E, Raimondi SC, Rowley JD, Gilliland DC. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA 1995; 92: 4917-4921.
15. Romana SP, Mauchauffe M, Le Coniat M, Chumakov I, Le Paslier D, Berger R, Bernard OA. The t(12;21) of acute lymphoblastic leukemia results in a TEL/AML1 gene fusion. Blood 1995; 85: 3662-3670.
16. Ichikawa H, Shimizu K, Hayashi Y, Ohki M. An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. Cancer Res 1994; 54: 2865-2868.