메뉴 건너뛰기




Volumn 49, Issue 5, 1997, Pages 1432-1438

MPTP induces dystonia and parkinsonism: Clues to the pathophysiology of dystonia

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE;

EID: 0030659028     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.49.5.1432     Document Type: Article
Times cited : (156)

References (46)
  • 1
    • 73649199960 scopus 로고
    • Die topische lokalisation und das verhalten von noradrenalin und dopamin in der substantia nigra des normalen und Parkinsonkranken Menschen
    • Hornykiewicz O. Die topische lokalisation und das verhalten von noradrenalin und dopamin in der substantia nigra des normalen und Parkinsonkranken Menschen. Wien Klin Wochenschr 1963;75:309-312.
    • (1963) Wien Klin Wochenschr , vol.75 , pp. 309-312
    • Hornykiewicz, O.1
  • 3
    • 0001496694 scopus 로고
    • A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methy-1-4-phenyl-1,2,3,6-tetrahydropyridine
    • Burns RS, Chiueh CC, Markey SP, Ebert MH, Jacobowitz DM, Kopin IJ. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methy]-1-4-phenyl-1,2,3,6-tetrahydropyridine. Proc Natl Acad Sci USA 1983;80:4546-4550.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 4546-4550
    • Burns, R.S.1    Chiueh, C.C.2    Markey, S.P.3    Ebert, M.H.4    Jacobowitz, D.M.5    Kopin, I.J.6
  • 4
    • 0021829406 scopus 로고
    • Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): Seven cases
    • Ballard PA, Tetrud JW, Langsten JW. Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): seven cases. Neurology 1985;35:949-956.
    • (1985) Neurology , vol.35 , pp. 949-956
    • Ballard, P.A.1    Tetrud, J.W.2    Langsten, J.W.3
  • 5
    • 0002682320 scopus 로고
    • MPTP-induced parkinsonism: A model of Parkinson's disease and its relevance to the disease process
    • Jankovic J, Tolosa, eds. Baltimore: Williams & Wilkins
    • Jenner P, Marsden CD. MPTP-induced parkinsonism: a model of Parkinson's disease and its relevance to the disease process. In: Jankovic J, Tolosa, eds. Parkinson's disease and movement disorders. 2nd ed. Baltimore: Williams & Wilkins, 1993:55-76.
    • (1993) Parkinson's Disease and Movement Disorders. 2nd Ed. , pp. 55-76
    • Jenner, P.1    Marsden, C.D.2
  • 6
    • 0023675531 scopus 로고
    • Concept and classification of dystonia
    • Fahn S. Concept and classification of dystonia. Adv Neurol 1988;50:1-8.
    • (1988) Adv Neurol , vol.50 , pp. 1-8
    • Fahn, S.1
  • 7
    • 0028344689 scopus 로고
    • A study of idiopathic torsion dystonia in a non-Jewish family: Evidence for genetic heterogeneity
    • Bressman S, Heiman G, Nygaard T, et al. A study of idiopathic torsion dystonia in a non-Jewish family: evidence for genetic heterogeneity. Neurology 1994;44:283-287.
    • (1994) Neurology , vol.44 , pp. 283-287
    • Bressman, S.1    Heiman, G.2    Nygaard, T.3
  • 8
    • 0027978063 scopus 로고
    • The behavioural and motor consequences of focal lesions of the basal ganglia in man
    • Bhatia K, Marsden CD. The behavioural and motor consequences of focal lesions of the basal ganglia in man. Brain 1994;117:859-876.
    • (1994) Brain , vol.117 , pp. 859-876
    • Bhatia, K.1    Marsden, C.D.2
  • 9
    • 84880510965 scopus 로고
    • Dystonic reactions following neuroleptics: Time course and proposed mechanisms
    • Berl
    • Garver D, Davis J, Dekirmenjian H, et al. Dystonic reactions following neuroleptics: time course and proposed mechanisms. Psychopharmacology (Berl) 1976;47:199-201.
    • (1976) Psychopharmacology , vol.47 , pp. 199-201
    • Garver, D.1    Davis, J.2    Dekirmenjian, H.3
  • 10
    • 0019482533 scopus 로고
    • Neuroleptic-induced acute dystonic reactions may be due to enhanced dopamine release on to supersensitive postsynaptic receptors
    • Kolbe H, Clow A, Jenner P, Marsden CD. Neuroleptic-induced acute dystonic reactions may be due to enhanced dopamine release on to supersensitive postsynaptic receptors. Neurology 1981;31:434-439.
    • (1981) Neurology , vol.31 , pp. 434-439
    • Kolbe, H.1    Clow, A.2    Jenner, P.3    Marsden, C.D.4
  • 11
    • 0022587986 scopus 로고
    • Acute dystonia induced by neuroleptic drugs
    • Berl
    • Rupniak N, Jenner P, Marsden CD. Acute dystonia induced by neuroleptic drugs. Psychopharmacology (Berl) 1986;88: 403-419.
    • (1986) Psychopharmacology , vol.88 , pp. 403-419
    • Rupniak, N.1    Jenner, P.2    Marsden, C.D.3
  • 12
    • 0026021079 scopus 로고
    • Dopa-responsive dystonia: Long-term treatment response and prognosis
    • Nygaard TG, Marsden CD, Fahn S. Dopa-responsive dystonia: long-term treatment response and prognosis. Neurology 1992; 41:174-181.
    • (1992) Neurology , vol.41 , pp. 174-181
    • Nygaard, T.G.1    Marsden, C.D.2    Fahn, S.3
  • 14
    • 0029049876 scopus 로고
    • Recessively inherited L-dopa-responsive dystonia caused by a point mutation (Q381K) in the tyrosine hydroxylase gene
    • Knappskog PM, Flatmark T, Mallet J, Ludecke B, Bartholome K. Recessively inherited L-dopa-responsive dystonia caused by a point mutation (Q381K) in the tyrosine hydroxylase gene. Hum Mol Genet 1995;4:1209-1212.
    • (1995) Hum Mol Genet , vol.4 , pp. 1209-1212
    • Knappskog, P.M.1    Flatmark, T.2    Mallet, J.3    Ludecke, B.4    Bartholome, K.5
  • 15
    • 0025363689 scopus 로고
    • Neural mechanisms of dystonia: Evidence from a 2-deoxyglucose uptake study in a primate model of dopamine agonist-induced dystonia
    • Mitchell I, Luguin R, Boyce S, et al. Neural mechanisms of dystonia: evidence from a 2-deoxyglucose uptake study in a primate model of dopamine agonist-induced dystonia. Mov Disord 1990;5:49-54.
    • (1990) Mov Disord , vol.5 , pp. 49-54
    • Mitchell, I.1    Luguin, R.2    Boyce, S.3
  • 16
    • 0029860816 scopus 로고    scopus 로고
    • 3 receptor protein and mRNA in responses to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) denervation in baboons
    • 3 receptor protein and mRNA in responses to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) denervation in baboons. J Neurosci 1996;16:7776-7782.
    • (1996) J Neurosci , vol.16 , pp. 7776-7782
    • Todd, R.D.1    Carl, J.2    Harmon, S.3    O'Malley4    Perlmutter, J.S.5
  • 17
    • 0019779457 scopus 로고
    • Dopamine metabolism following irreversible inactivation of aromatic amino acid decarboxylase in retina
    • Parkinson D, Baughman R, Masland RH, Rando RR. Dopamine metabolism following irreversible inactivation of aromatic amino acid decarboxylase in retina. J Neurosci 1981;1: 1205-1210.
    • (1981) J Neurosci , vol.1 , pp. 1205-1210
    • Parkinson, D.1    Baughman, R.2    Masland, R.H.3    Rando, R.R.4
  • 18
    • 0022589131 scopus 로고
    • Hemiparkinsonism in monkeys after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    • Bankiewicz K, Oldfield E, Chiueh C, Doppman J, Jacobowitz D, Kopin I. Hemiparkinsonism in monkeys after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Life Sci 1986;39:7-16.
    • (1986) Life Sci , vol.39 , pp. 7-16
    • Bankiewicz, K.1    Oldfield, E.2    Chiueh, C.3    Doppman, J.4    Jacobowitz, D.5    Kopin, I.6
  • 19
    • 0025280182 scopus 로고
    • Intracarotid 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration: Biochemical and behavioral observations in a primate model of hemiparkinsonism
    • Guttman M, Fibiger HC, Jakubovic A, Calne DB. Intracarotid 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration: biochemical and behavioral observations in a primate model of hemiparkinsonism. J Neurochem 1990;54:1329-1334.
    • (1990) J Neurochem , vol.54 , pp. 1329-1334
    • Guttman, M.1    Fibiger, H.C.2    Jakubovic, A.3    Calne, D.B.4
  • 20
    • 0025260716 scopus 로고
    • Local cerebral glucose utilization in monkeys with hemiparkinsonism induced by intracarotid infusion of the neurotoxin MPTP
    • Palombo E, Porrino LJ, Bankiewicz KS, Crane AM, Sokoloff L, Kopin IJ. Local cerebral glucose utilization in monkeys with hemiparkinsonism induced by intracarotid infusion of the neurotoxin MPTP. J Neurosci 1990;10:860-869.
    • (1990) J Neurosci , vol.10 , pp. 860-869
    • Palombo, E.1    Porrino, L.J.2    Bankiewicz, K.S.3    Crane, A.M.4    Sokoloff, L.5    Kopin, I.J.6
  • 21
    • 0022543572 scopus 로고
    • Hemiparkinsonism in a monkey after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is associated with regional ipsilateral changes in striatal dopamine D-2 receptor density
    • Joyce JN, Marshall JF, Bankiewicz KS, Kopin IJ, Jacobowitz DM. Hemiparkinsonism in a monkey after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is associated with regional ipsilateral changes in striatal dopamine D-2 receptor density Brain Res 1986;382:360-364.
    • (1986) Brain Res , vol.382 , pp. 360-364
    • Joyce, J.N.1    Marshall, J.F.2    Bankiewicz, K.S.3    Kopin, I.J.4    Jacobowitz, D.M.5
  • 25
    • 0029079994 scopus 로고
    • Dopa-responsive dystonia
    • Nygaard T. Dopa-responsive dystonia. Curr Opin Neurol 1995;8:310-313.
    • (1995) Curr Opin Neurol , vol.8 , pp. 310-313
    • Nygaard, T.1
  • 26
    • 0029063359 scopus 로고
    • Hemiatrophy, juvenile-onset exertional alternating leg paresis, hypotonia, and hemidystonia and adult-onset hemiparkinsonism: The spectrum of hemiparkinsonism-hemiatrophy syndrome
    • Lang AE. Hemiatrophy, juvenile-onset exertional alternating leg paresis, hypotonia, and hemidystonia and adult-onset hemiparkinsonism: the spectrum of hemiparkinsonism-hemiatrophy syndrome. Mov Disord 1995;10:489-495.
    • (1995) Mov Disord , vol.10 , pp. 489-495
    • Lang, A.E.1
  • 27
    • 0024450903 scopus 로고
    • The functional anatomy of basal ganglia disorders
    • Albin RL, Young AB, Penney JB. The functional anatomy of basal ganglia disorders. Trends Neurosci 1989;12:366-375.
    • (1989) Trends Neurosci , vol.12 , pp. 366-375
    • Albin, R.L.1    Young, A.B.2    Penney, J.B.3
  • 28
    • 0025321039 scopus 로고
    • Functional architecture of basal ganglia circuits: Neural substrates of parallel processing
    • Alexander GE, Crutcher MD. Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci 1990;13:266-271.
    • (1990) Trends Neurosci , vol.13 , pp. 266-271
    • Alexander, G.E.1    Crutcher, M.D.2
  • 29
    • 0025572196 scopus 로고
    • D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
    • Gerfen CR, Engber TM, Mahan LC, et al. D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science 1990;250:1429-1432.
    • (1990) Science , vol.250 , pp. 1429-1432
    • Gerfen, C.R.1    Engber, T.M.2    Mahan, L.C.3
  • 30
    • 0026531301 scopus 로고
    • The neostriatal mosaic: Multiple levels of compartmental organization
    • Gerfen CR. The neostriatal mosaic: multiple levels of compartmental organization. Trends Neurosci 1992;15:133-139.
    • (1992) Trends Neurosci , vol.15 , pp. 133-139
    • Gerfen, C.R.1
  • 31
    • 0029008717 scopus 로고
    • D1-D2 dopamine receptor synergy in striatum: Effects of intrastriatal infusions of dopamine agonists and antagonists on immediate early gene expression
    • Keefe KA, Gerfen CR. D1-D2 dopamine receptor synergy in striatum: effects of intrastriatal infusions of dopamine agonists and antagonists on immediate early gene expression. Neuroscience 1995;66:903-913.
    • (1995) Neuroscience , vol.66 , pp. 903-913
    • Keefe, K.A.1    Gerfen, C.R.2
  • 33
    • 0025302002 scopus 로고
    • Abnormal vibration-induced cerebral blood flow responses in dystonia
    • Tempel L, Perlmutter J. Abnormal vibration-induced cerebral blood flow responses in dystonia. Brain 1990;113:691-707.
    • (1990) Brain , vol.113 , pp. 691-707
    • Tempel, L.1    Perlmutter, J.2
  • 34
    • 0027372881 scopus 로고
    • Abnormal cortical responses to vibration in patients with writer's cramp
    • Tempel LW, Perlmutter JS. Abnormal cortical responses to vibration in patients with writer's cramp. Neurology 1993;43: 2252-2257.
    • (1993) Neurology , vol.43 , pp. 2252-2257
    • Tempel, L.W.1    Perlmutter, J.S.2
  • 35
    • 0027759549 scopus 로고
    • Basal ganglia intrinsic circuits and their role in behavior
    • Mink JW, Thach WT. Basal ganglia intrinsic circuits and their role in behavior. Curr Opin Neurobiol 1993;3:950-957.
    • (1993) Curr Opin Neurobiol , vol.3 , pp. 950-957
    • Mink, J.W.1    Thach, W.T.2
  • 36
    • 0030294556 scopus 로고    scopus 로고
    • The basal ganglia: Focused selection and inhibition of competing motor programs
    • Mink JW. The basal ganglia: focused selection and inhibition of competing motor programs. Prog Neurobiol 1996;50:381-425.
    • (1996) Prog Neurobiol , vol.50 , pp. 381-425
    • Mink, J.W.1
  • 37
    • 0025944714 scopus 로고
    • Dopamine differentially regulates dynorphin, substance P and enkephalin expression in striatal neurons: In situ hybridization histochemical analysis
    • Gerfen CR, McGintry JF, Young WS. Dopamine differentially regulates dynorphin, substance P and enkephalin expression in striatal neurons: in situ hybridization histochemical analysis. J Neurosci 1991;11:1016-1031.
    • (1991) J Neurosci , vol.11 , pp. 1016-1031
    • Gerfen, C.R.1    McGintry, J.F.2    Young, W.S.3
  • 38
    • 0030910350 scopus 로고    scopus 로고
    • PET measurement of dopamine D2 receptor-mediated changes in striatopallidal function
    • Black KJ, Gado MH, Perlmutter JS. PET measurement of dopamine D2 receptor-mediated changes in striatopallidal function. J Neurosci 1997;17:3168-3177.
    • (1997) J Neurosci , vol.17 , pp. 3168-3177
    • Black, K.J.1    Gado, M.H.2    Perlmutter, J.S.3
  • 39
    • 0025854390 scopus 로고
    • Abnormal spontaneous activity of globus pallidus neurons in monkey with MPTP-induced parkinsonism
    • Filion M, Tremblay L. Abnormal spontaneous activity of globus pallidus neurons in monkey with MPTP-induced parkinsonism. Brain Res 1991;547:142-151.
    • (1991) Brain Res , vol.547 , pp. 142-151
    • Filion, M.1    Tremblay, L.2
  • 40
    • 0025933902 scopus 로고
    • Non-steady-state measurement of in vivo radioligand binding with positron emission tomography: Specificity analysis and comparison with in vitro binding
    • Perlmutter JS, Moerlein S, Huang D-R, Todd R. Non-steady-state measurement of in vivo radioligand binding with positron emission tomography: specificity analysis and comparison with in vitro binding. J Neurosci 1991;11:1381-1389.
    • (1991) J Neurosci , vol.11 , pp. 1381-1389
    • Perlmutter, J.S.1    Moerlein, S.2    Huang, D.-R.3    Todd, R.4
  • 41
    • 0343363010 scopus 로고
    • Imaging the pre- and postsynaptic side of striatal dopaminergic synapses in idiopathic focal dystonia: A SPECT study using β-CIT and epidepride
    • Naumann M, Pirker W, Reiners K, Brücke T. Imaging the pre- and postsynaptic side of striatal dopaminergic synapses in idiopathic focal dystonia: a SPECT study using β-CIT and epidepride. Mov Disord 1990;11(suppl 1):206.
    • (1990) Mov Disord , vol.11 , Issue.1 SUPPL. , pp. 206
    • Naumann, M.1    Pirker, W.2    Reiners, K.3    Brücke, T.4
  • 42
    • 0019903999 scopus 로고
    • Writer's cramp - A focal dystonia
    • Sheehy M, Marsden C. Writer's cramp - a focal dystonia. Brain 1982;105:461-480.
    • (1982) Brain , vol.105 , pp. 461-480
    • Sheehy, M.1    Marsden, C.2
  • 44
    • 0029665122 scopus 로고    scopus 로고
    • Levodopa-induced dyskinesias improved by a glutamate antagonist in parkinsonian monkeys
    • Papa SM, Chase TN. Levodopa-induced dyskinesias improved by a glutamate antagonist in parkinsonian monkeys. Ann Neurol 1996;39:557-558.
    • (1996) Ann Neurol , vol.39 , pp. 557-558
    • Papa, S.M.1    Chase, T.N.2
  • 45
    • 0026728032 scopus 로고
    • Dystonia induced by combined treatment with L-dopa and MK-801 in parkinsonian monkeys
    • Rupniak N, Boyce S, Steventon M, Iversen S, Marsden CD. Dystonia induced by combined treatment with L-dopa and MK-801 in parkinsonian monkeys. Ann Neurol 1992;32: 103-105.
    • (1992) Ann Neurol , vol.32 , pp. 103-105
    • Rupniak, N.1    Boyce, S.2    Steventon, M.3    Iversen, S.4    Marsden, C.D.5
  • 46
    • 0028232327 scopus 로고
    • Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease
    • Greenamyre JT, Eller RV, Zhang Z, et al. Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease. Ann Neurol 1994;35:655-661.
    • (1994) Ann Neurol , vol.35 , pp. 655-661
    • Greenamyre, J.T.1    Eller, R.V.2    Zhang, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.