Expression of c-Kit and functional drug efflux are correlated in de novo acute myeloid leukaemia

Leukemia

Volumn 11, Issue 11, 1997, Pages 1850-1857

  Sincock, P M ^a   Ashman, L K ^a  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

Author keywords

AML; c Kit; MDR; P glycoprotein

Indexed keywords

GLYCOPROTEIN P; MONOCLONAL ANTIBODY; RHODAMINE 123; STEM CELL FACTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CELL DIFFERENTIATION; CLINICAL ARTICLE; DRUG TRANSPORT; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MULTIDRUG RESISTANCE; ONCOGENE C KIT; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS;

EID: 0030657009     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400823     Document Type: Article

References (13)

1. Chaudhary PM, Roninson IB. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 1991; 66: 85-94.
2. Kuwazuru Y, Yoshimura A, Hanada S, Utsunomiya A, Makino T, Ishibashi K, Kodama M, Iwahashi M, Arima T, Akiyama S-I. Expression of the multidrug transporter P-glycoprotein, in acute leukaemia cells and correlation to clinical drug resistance. Cancer 1990; 66: 868-873.
3. te Boekhorst PAW, de Leeuw K, Schoester M, Wittebol S, Nooter K, Hagemeijer A, Lowenberg B, Sonneveld P. Predominance of functional multidrug resistance (MDR-1) phenotype in CD34+ acute myeloid leukaemia cells. Blood 1993; 82: 3157-3162.
4. Del Poeta G, Stasi R, Venditti A, Suppo G, Aronica G, Bruno A, Masi M, Tabilio A, Papa G. Prognostic value of cell marker analysis in de novo acute myeloid leukaemia. Leukemia 1994; 8: 388-394.
5. Zochbauer S, Gsur A, Brunner R, Kyrie PA, Lechner K, Pirker R. P-glycoprotein expression as an unfavourable prognostic marker in acute myeloid leukaemia. Leukemia 1994; 8: 974-977.
6. Gadd SJ, Ashman LK. A murine monoclonal antibody specific for a cell-surface antigen expressed by a subgroup of human myeloid leukaemias. Leukemia Res 1985; 9: 1329-1336.
7. Cambareri AC, Ashman LK, Cole SR, Lyons AB. A monoclonal antibody to a human mast cell/myeloid leukemia specific antigen binds to normal hemopoietic progenitor cells and inhibits colony formation in vitro. Leukemia Res 1988; 12: 929-939.
8. Ashman LK, Cambareri AC, To LB, Levinsky RJ, Juttner CA. Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow. Blood 1991; 78: 30-37.
9. Simmons PJ, Aylett GW, Niutta S, To B, Juttner CA, Ashman LK. C-kit is expressed by primitive human haemopoietic cells that give rise to colony-forming cells in stroma-dependent or cytokine supplemented culture, Exp Hematol 1994; 22: 157-165.
10. Giessler EN, Ryan MA, Housman DE. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 1988; 55: 185-192.
11. Chabot B, Stephenson DA, Chapman VM, Besmer P, Bernstein A. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 1988; 335: 88-89.
12. Lerner NB, Nocka KH, Cole SR, Qui F, Strife A, Ashman LK, Besmer P. Monoclonal antibody YB5.B8 identifies the human c-kit protein product. Blood 1991; 77: 1876-1883.
13. Ashman LK, Roberts MM, Gadd SJ, Cooper SJ, Juttner CA. Expression of a 150-kD cell surface antigen identified by monoclonal antibody YB5.B8 is associated with poor prognosis in acute non-lymphoblastic leukaemia. Leukemia Res 1988; 12: 923-928.