Immunohistochemical and ultrastructural analyses of in situ activation of hepatic stellate cells around Propionibacterium acnes-induced granulomas in the rat liver

Journal of Submicroscopic Cytology and Pathology

Volumn 29, Issue 1, 1997, Pages 125-133

  Tsuji, N ^a   Kawada, N ^a   Ikeda, K ^a   Kinoshita, H ^a   Kaneda, K ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Granuloma; Growth factors; Macrophages; Propionibacterium acnes; Stellate cells

Indexed keywords

ANIMAL; ARTICLE; BACTERIAL INFECTION; CHEMISTRY; GRANULOMA; IMMUNOHISTOCHEMISTRY; KINETICS; LIVER; MALE; METABOLISM; MICROBIOLOGY; PATHOLOGY; PROPIONIBACTERIUM ACNES; RAT; ULTRASTRUCTURE; WISTAR RAT;

ANIMALS; GRAM-POSITIVE BACTERIAL INFECTIONS; GRANULOMA; IMMUNOHISTOCHEMISTRY; KINETICS; LIVER; MALE; PROPIONIBACTERIUM ACNES; RATS; RATS, WISTAR;

EID: 0030642128     PISSN: 11229497     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. ARENSON D.M., FRIEDMAN S.L. and BISSELL D.M., 1988. Formation of extracellular matrix in normal rat liver: lipocytes as a major source of proteoglycan. Gastroenterology, 95, 441-447.
2. BACHEM M.G., RIESS U. and GRESSNER A.M., 1989. Liver fat storing cell proliferation is stimulated by epidermal growth factor/transforming growth factor alpha and inhibited by transforming growth factor beta. Biochem. Biophys. Res. Commun., 162, 708-714.
3. BACHEM M.G., MEYER D., RIESS U., MELCHIOR R., SELL K.M., BITTINGER A. and GRESSNER A.M., 1991. Paracrine stimulation of fat storing cells via soluble mediators produced by myofibroblast-like cells In: 'Cells of the Hepatic Sinusoid'. Wisse E., Knock D.L. and McCuskey R.S. eds., Kupffer Cell Foundation, Rijswijk, The Netherlands, vol. 3, pp. 164-170.
4. BALLARDINI G., FALLANI M., BIAGINI G., BIANCHI F.B. and PISI E., 1988. Desmin and actin in the identification of Ito cells and in monitoring their evolution to myofibroblasts in experimental liver fibrosis. Virchows Arch. B Cell Pathol., 56, 45-49.
5. BLOMHOFF R. and WAKE K., 1991. Perisinusoidal stellate cells of the liver: Important roles in retinol metabolism and fibrosis. FASEB J., 5, 271-277,
6. BURT A.O., ROBERTSON J., HEIR J. and MACSWEEN R.N.M., 1986. Desmin-containing stellate cells in rat liver; distribution in normal animals and response to experimental acute liver injury. J. Pathol., 50, 29-35.
7. ENZAN H., 1985. Proliferation of Ito cells (fat-storing cells) in acute carbon tetrachloride injury. A light and electron microscopic autoradiographic study. Acta Pathol. Jpn., 35, 1301-1308.
8. FRIEDMAN S.L. and ARTHUR M.J.P., 1989. Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. J. Clin. Invest., 84, 1780-1785.
9. GEERTS A., VRIJSEN R., RAUTERBERG J., BURT A., SCHELLINCK P. and WISSE E., 1989. In vitro differentiation of fat-storing cells parallels marked increase of collagen synthesis and secretion. J. Hepatol., 9, 59-69.
10. 4 injured rat liver. Hepatology, 13, 1193-1202.
11. HOUSSET C.N., ROCKEY D.C. and BISSELL D.M., 1993. Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin 1. Proc. Natl. Acad. Sci. USA, 90, 9266-9270.
12. IREDALE J.P., WINWOOD P.J., KAWSER C.A. and ARTHUR M.J.P., 1993. Lipocyte proliferation in the C. parvum model of macrophage-induced liver injury is associated with expression of 72 KDa type IV collagenase/gelatinase. In: 'Cells of the Hepatic Sinusoid'. Knook D.L. and Wisse E. eds., Kupffer Cell Foundation, The Netherlands, vol. 4, pp. 105-108.
13. JOHNSON S.J., HINES J.E. and BURT A.D., 1992. Macrophage and perisinusoidal cell kinetics in acute liver injury. J. Pathol., 166, 351-358.
14. KNITTEL T., SCHUPPAN D., MEYER ZUM BUSCHENFELDE K. and RAMADORI G., 1992. Differential expression of collagen type I, III and IV by fat-storing (Ito) cells in vitro. Gastroenterology, 102, 1724-1735.
15. LUKITA-ATMADJA W, SATO T. and WAKE K., 1993. Granuloma formation in the liver of Balb/c mice intoxicated with carbon tetrachloride. Virchows Arch. B Cell Pathol., 64, 247-257.
16. MAHER J.J., FRIEDMAN S.L., ROLL F.J. and BISSELL D.M., 1988. Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocyte in primary culture. Gastroenterology, 94, 1053-1062.
17. MAK K.M., LEO M.A. and LIEBER C.S., 1984. Alcoholic liver injury in baboons: transformation of lipocytes to transitional cells. Gastroenterology, 87, 188-200.
18. MATSUOKA M., PHAM N. and TSUKAMOTO H., 1989. Differential effects of interleukin-1α, tumor necrosis factor α and transforming growth factor β1 on cell proliferation and collagen formation by cultured fat-storing cells. Liver, 9, 71-78.
19. PINZANI M., GESUALDO L., SABBAH G.M. and ABBOUD H.E., 1989. Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J. Clin. Invest., 84, 1786-1793.
20. PINZANI M., FAILLI P., RUOCCO C., CASINI A., MILANI S., BALDI E., GIOTTI A. and GENTILINI P., 1992. Fat-storing cells as liver-specific pericytes: spatial dynamics of agonist-stimulated intracellular calcium transients. J. Clin. Invest., 90, 642-646.
21. RAMADORI G., 1991. The stellate cell (Ito cell, fat-storing cell, lipocyte, perisinusoidal cell) of the liver. New insight into pathophysiology of an intriguing cell. Virchows Arch. B Cell Pathol., 61, 147-158.
22. ROCKEY D.C., HOUSSET C.N. and FRIEDMAN S.L., 1993. Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo. J. Clin. Invest., 92, 1795-1804.
23. ROJKIND M., 1985. Collagen metabolism in the liver. In: 'Alcoholic Liver Disease'. Hall P. de la M. ed., Edward Arnold, London, pp. 167-183.
24. SCHMITT-GRAFF A., KRUGER S., BOCHARD F., GABBIANI G. and DENK H., 1991. Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers. Am. J. Pathol., 138, 1233-1242.
25. 4 induced fibrotic livers stimulate proliferation of fat-storing cells. J. Hepatol., 3, 294-303.
26. TAKAHARA T., KOJIMA T., MIYABASHI C., INOUE K., SASAKI H., MURAGAKI Y. and OOSHIMA A., 1988. Collagen production in fat-storing cells after carbon tetrachloride intoxication in the rat. Immunoelectron microscopic observation of type I, type III collagens, and propyl hydroxylase. Lab. Invest., 59, 509-521.
27. WAKE K., 1980. Perisinusoidal stellate cells (fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sinusoids, and vitamin A-storing cells in extrahepatic organs. Int. Rev. Cytol., 66, 303-353.
28. YAMAMOTO H., KANEDA K., KAMADA N. and WAKE K., 1994. Morphometric analysis of infiltrating cells that adhere to the sinusoidal wall and migrate into the space of Disse in the orthotopically transplanted rat liver. Transplantation, 58, 8-13.
29. ZERBE O. and GRESSNER A.M., 1988. Proliferation of fat-storing cells is stimulated by secretions of Kupffer cells from normal and injured liver. Exp. Mol. Pathol., 49, 87-101.