Ig N-Glycan Orientation Can Influence Interactions with the Complement System

Journal of Immunology

Volumn 158, Issue 1, 1997, Pages 426-435

  White, Kendra D ^a   Cummings, Richard D ^a   Waxman, Frank J ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDASE; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C4B; GLYCOPEPTIDASE; GLYCOSYLTRANSFERASE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; PEPTIDE; POLYSACCHARIDE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; COMPLEMENT ACTIVATION; CONFORMATION; GLYCOSYLATION; IMMUNOGLOBULIN CONSTANT REGION; IMMUNOLOGY; ISOELECTRIC FOCUSING; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN BINDING; PROTEIN CONFORMATION;

AMIDOHYDROLASES; ANIMALS; CARBOHYDRATE CONFORMATION; COMPLEMENT ACTIVATION; COMPLEMENT C1Q; COMPLEMENT C3B; COMPLEMENT C4B; GLYCOSYLATION; GLYCOSYLTRANSFERASES; IMMUNOGLOBULIN CONSTANT REGIONS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; ISOELECTRIC FOCUSING; MICE; MICE, INBRED BALB C; PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL) ASPARAGINE AMIDASE; PEPTIDES; POLYSACCHARIDES; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 0030639209     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Horgan, C., K. Brown, and S. H. Pincus. 1990. Alteration in H chain V region affects complement activation by chimeric antibodies. J. Immunol. 145:2527.
2. Horgan, C., K. Brown, and S. H. Pincus. 1992. Effect of H chain V region on complement activation by immobilized immune complexes. J. Immunol. 149: 127.
3. Yokoyama, L. and F. Waxman. 1993. Clonal variations in complement activation and deposition of C3b and C4b on model immune complexes. Immunology 80: 168.
4. White, K. D., M. B. Frank, S. Foundling, and F. J. Waxman. 1996. Effect of immunoglobulin variable region structure on C3b and C4b deposition. Mol. Immunol. 33:759.
5. Tao, M. H., and S. L. Morrison. 1989. Studies of aglycosylated chimeric mouse-human IgG: role of carbohydrate in the structure and effector functions mediated by the human IgG constant region. J. Immunol. 143:2595.
6. Nose, M., and H. Wigzell. 1983. Biological significance of carbohydrate chains on monoclonal antibodies. Proc. Natl. Acad. Sci. USA 80:6632.
7. Leatherbarrow, R. J., T. W. Rademacher, and R. A. Dwek. 1985. Effector functions of a monoclonal aglycosylated mouse IgG2a: binding and activation of complement component C1 and interaction with human monocyte Fc receptor. Mol. Immunol. 22:407.
8. H2-associatcd carbohydrate structure on the functional properties and in vivo fate of chimeric mouse-human immunoglobulin G1. J. Exp. Med. 180:1087.
9. Duncan, R. D., and G. Winter. 1988. The binding site lor C1q on IgG. Nature 332:738.
10. Yokoyama, I., and F. Waxman. 1992. Isotypic and clonal variations in the interactions between model monoclonal immune complexes and the human erythrocyte CRI receptor. Mol. Immunol. 29:935.
11. Yokoyama, I., and F. Waxman. 1994. Differential susceptibility of immune complexes to release from the erythrocyte CR1 receptor by factor I. Mol. Immunol. 31:227.
12. Mattox, S., K. Walrath, D. Ceiler, D. H. Smith, and R. D. Cummings. 1992. A solid phase assay for the activity of CMPNeuAc:Galβ1-4GlcNAc-R α-2,6-sialyltransferase. Anal. Biochem. 206:430.
13. Sikorav, J. L., C. Auffray, and F. Rougeon. 1980. Structure of the constant and 3′ untranslated regions of the murine BALB/c gamma-2a heavy chain. Nucleic Acids Res. 8:3143.
14. Rademacher, T. W., S. W. Homans, R. B. Parekh, and R. A. Dwek. 1986. Immunoglobulin G as a glycoprotein. Biochem. Soc. Symp. 51:131.
15. Baenziger, J. U. 1994. Protein-specific glycosyltransferases: how and why they do it. FASEB J. 8:1019.
16. Do, K. Y., N. Fregien, M. Pierce, and R. D. Cummings. 1994. Modification of glycoproteins by N-acetylglucoaminyltransferase V is greatly influenced by accessibility of the enzymes to oligosaccharide acceptors. J. Biol. Chem. 269:23456.
17. Roquemore, E., T. Chou, and G. W. Hart. 1994. Detection of O-linked N-acetylglucosamine (O-GlcNAc) on cytoplasmic and nuclear proteins. Methods Enzymol. 230:443.
18. Folkherd, E. J., B. Gardner, and N. C. Hughes-Jones. 1980. The relationship between the binding ability and the rale of activation of complement component CI. Immunology 41:179.
19. Tao, M. H., R. I. F. Smith, and S. L. Morrison. 1993. Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation. J. Exp. Med. 178:661.
20. Bindon, C. I., G. Hale, and H. Waldmann. 1990. Complement activation by immunoglobulin does not solely depend on CIq binding. Eur. J. Immunol. 20: 277.
21. Matsuuchi, L., J. Sharon, and S. L. Morrison. 1981. An analysis of heavy chain glycopeptides of hybridoma antibodies: correlation between antibody specificity and sialic acid content. J. Immunol. 127:2188.
22. Matsuda, H., S. Nakamura, Y. Ichikawa, K. Kozai, R. Takano, M. Nose, S. Endo, Y. Nishimura, and Y. Arata. 1990. Proton nuclear magnetic resonance studies of the structure of the Fc fragment of human immunoglobulin G1: comparisons of native and recombinant proteins. Mol. Immunol. 27:571.
23. Lund, J., T. Tanaka, N. Takahashi, G. Sarmay, Y. Arata, and R. Jefferis. 1990. A protein structural change in aglycosylated IgG3 correlates with loss of huFcγR1 and huFcγR111 binding and/or activation. Mol. Immunol. 27:1145.
24. Deisenhofer, J. 1981. Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9-and 2.8-Å resolution. Biochemistry 20:2361.
25. Sutton, B. J., and D. C. Phillips. 1982. The three-dimensional structure of the carbohydrate within the Fc fragment of immunoglobulin G. Biochem. Soc. Trans. 11:130.
26. Tsuchiya, N., T. Endo, K. Matsuta, S. Yoshinoya, T. Aikawa, E. Kosuge, F. Takeuchi, T. Miyamoto, and A. Kobata. 1989. Effects of galactose depletion from oligosaccharide chains on immunological activities of human IgG. J. Rheumatol. 16:285.
27. Koide, N., M. Nose, and T. Muramatsu. 1977. Recognition of IgG Fc receptor und complement: effects of glycosidase digestion. Biochem. Biophys. Res. Commun. 75:838.
28. Horwitz, A. H., C. P. Chang, M. Belter, K. E. Hellstrom, and R. R. Robinson, 1988. Secretion of functional antibody and Fab fragment from yeast cells. Proc. Natl. Acad. Sci. USA 85:8678.
29. Huber, R., J. Deisenhofer, P. M. Colman, and M. Matsushima. 1976. Crystallographic structure studies of an IgG molecule and an Fc fragment. Nature 264:415.
30. Silverton, E. W., M. A. Navia, and D. R. Davies. 1977. Three-dimensional structure of an intact human immunoglobulin. Proc. Natl. Acad. Sci. USA 74:5140.
31. Parekh, R. B., A. G. D. Tse, R. A. Dwek, A. F. Williams, and T. W. Rademacher. 1987. Tissue-specific N-glycosylation, site-specific oligosaccharide patterns and lentil lectin recognition of rat Thy-1. EMBO J. 6:1233.
32. Rademacher, T. W., R. B. Parekh, and R. A. Dwek. 1988. Glycobiology. Annu. Rev. Biochem. 57:785.
33. Mullinax, F., A. J. Hymes, and G. L. Mullinax. 1976. Molecular site and enzymatic origin of IgG galactose deficiency in rheumatoid arthritis and SLE. Arthritis Rheum. 19:813.
34. Parekh, R. B., R. A. Dwek, B. J. Sutton, D. L. Fernandes, and A. Leung. 1985. Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total IgG. Nature 316:452.
35. Axford, J. S., N. Sumar, A. Alavi, D. A. Isenberg, A. Young, K. B. Bodman, and I. M. Roitt. 1992. Changes in normal glycosylation mechanisms in autoimmune rheumatic disease. J. Clin. Invest. 89:1021.
36. Rademacher, T. W., R. B. Parekh, R. A. Dwek, D. Isenberg, G. Rook, J. S. Axford, and I. Roitt. 1988. The role of IgG glycoforms in the pathogenesis of rheumatoid arthritis. Springer Semin. Immunopathol. 10:231.