Blockade of KATP channels with Glibenclamide does not abolish preconditioning during demand ischemia

American Journal of Cardiology

Volumn 79, Issue 1, 1997, Pages 75-78

  Correa, Steven D ^a   Schaefer, Saul ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIDIABETIC AGENT; GLIBENCLAMIDE; POTASSIUM CHANNEL;

ADAPTATION; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ELECTROCARDIOGRAPHY; EXERCISE TEST; FEMALE; HEART MUSCLE ISCHEMIA; HEART PACING; HUMAN; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADAPTATION, PHYSIOLOGICAL; ADENOSINE TRIPHOSPHATE; AGED; CARDIAC PACING, ARTIFICIAL; DOUBLE-BLIND METHOD; ELECTROCARDIOGRAPHY; EXERCISE TEST; FEMALE; GLYBURIDE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; POTASSIUM CHANNELS;

EID: 0030638197     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(96)00681-9     Document Type: Article

References (18)

1. McAlpin R, Kattus A. Adaptation to exercise in angina pectoris, the electrocardiogram during treadmill walking and coronary angiographic findings. Circulation 1966;33:183-201.
2. Williams D, Bass T, Gewirtz H, Most A. Adaptation to the stress of tachycardia in patients with coronary artery disease: insight into the mechanism of the warm-up phenomenon. Circulation 1985;71:687-692.
3. Van Winkle D, Chien G, Wolff R, Soifer B, Kuzume K, Davis R. Cardioprotection provided by adenosine receptor activation is abolished by blockade of the KATP channel. Am J Physiol 1994;35:H829-H839.
4. Kloner R, Yellon D. Does ischemic preconditioning occur in patients? J Am Coll Cardiol 1994;24:1133-1142.
5. 1 adenosine receptors in rabbit heart. Circulation 1991;84:350-356.
6. Deutsch E, Berger M, Kussmaul KG, Hirshfeld JW, Herrmann HC, Laskey WK. Adaptation to ischemia during percutaneous transluminal coronary angioplasty. Circulation 1990;82:2044-2051.
7. Tomai F, Crey F, Gaspardone A. Ischemic preconditioning during coronary angioplasty is prevented by glibenclamide, a selective ATP-sensitive K+ channel blocker. Circulation 1994;90:700-705.
8. Carmeliet E, Storms L, Vereecke J. The ATP 2Ddependent K 2Dchannel. In: Zipes D, Jalife J, eds. Cardiac Electrophysiology from Cell to Bedside. Philadelphia: WB Saunders, 1990:103-108.
9. + channel? Circ Res 1995;77:1030-1035.
10. ATP channels. Am J Physiol 1995;268:H2294-H2301.
11. Fralix T, Steenbergen C, London R, Murphy E. Glibenclamide does not abolish the protective effect of preconditioning on stunning in the isolated perfused rat heart. Cardiovasc Res 1993;27:630-637.
12. + channels. Circulation 1996;93: 178-186.
13. + loss during hypoxia, ischemiaand metabolic inhibition in mammalian ventricle. Circ Res 1991;69:623-637.
14. 31P NMR studies of porcine myocardium in vivo. J Clin Invest 1990;85:706-713.
15. Massie BM, Schwartz GG, Garcia J, Wisneski JA, Weiner MW, Owens T. Myocardial metabolism during increased work states in the porcine left ventricle in vivo. Circ Res 1994;74:64-73.
16. Kroll K, Martin GV. Comparison of myocardial ATP, blood flow, and cytosolic adenosine in demand iscehmia and coronary occlusion. Am J Physiol 1995;269:H819-H828.
17. + current during hypoxia: correlation with tissue ATP levels. Am J Physiol 1991;261:H671-H676.
18. Klimt C, Knatterud G, Meinert C, Prout T. A study of the effects of hypoglycemic agents on vascular complications in patients with adult onset diabetes. Diabetes 1970;19:747-830.