The 5-HT2 receptor agonist MK-212 reduces food intake and increases resting but prevents the behavioural satiety sequence

Pharmacology Biochemistry and Behavior

Volumn 56, Issue 1, 1997, Pages 41-46

  Halford, J C G ^a   Lawton, C L ^a   Blundell, J E ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

behavioural satiety sequence; food intake; MK 212 5 HT2; sedation

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; 6 CHLORO 2 (1 PIPERAZINYL)PYRAZINE; SEROTONIN AGONIST; PYRAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANOREXIA; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEEDING BEHAVIOR; FOOD INTAKE; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SATIETY; SEDATION; SEROTONINERGIC SYSTEM; ANIMAL; EATING; GROOMING; MOTOR ACTIVITY; PSYCHOPHYSIOLOGY; TIME;

ANIMALS; EATING; FEEDING BEHAVIOR; GROOMING; MALE; MOTOR ACTIVITY; PYRAZINES; RATS; SATIETY RESPONSE; SEROTONIN AGONISTS; TIME FACTORS;

EID: 0030636993     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(96)00152-9     Document Type: Article

References (26)

1. Antin J., Gibbs J., Holt J., Young R. C., Smith G. P. Cholecystokinin elicits the complete behavioural sequence of satiety in rats. J. Comp. Physiol. Psych. 89:1975;784-760.
2. Blundell J. E. Is there a role for serotonin (5-hydroxytryptamine) in feeding? International J. Obesity. 1:1977;15-42.
3. Blundell, J. E.; Alikhan, H.: Analysing the structure and sequence of feeding in animals and man. In: Christie, W. M.; Weinman, J., ed. Microcompters, psychology and medicine. Wiley; 1990:203-225.
4. Blundell J. E., Latham C. J. Pharmacological manipulations of feeding behaviour. Possible influences of serotonin and dopamine on food intake Garattini S., Samanin R. Central mechanisms of anorectic drugs. 1978;83-109 Raven Press, New York.
5. Blundell J. E., Latham C. J. Characteristic adjustments to the structure of feeding behaviour following pharmacological treatments. Effects of amphetamine and fenfluramine and the antagonism produce by pimozide and metergoline Pharmacol. Biochem. Behav. 12:1980;717-722.
6. Blundell J. E., McArther R. A. Behavioural flux and feeding. Continuous monitoring of food intake and food selection, and the video-recording of appetitive and satiety sequences for the analysis of drug action Samanin R., Garattini S. Anorectic agents. Mechanisms of action and tolerance:1981;19-43 Raven Press, New York.
7. Clifton, P. G.: The neuropharmacology of meal patterning. In: Cooper, S. J.; Hendrie, C. A., eds. Ethology and psychopharmacology. Wiley; 1994:313-328.
8. Clineschmidt B. V., McGuffen J. C., Pfeuger A. B., Totaro J. A. A 5-hydroxytrytamine-like mode of action for 6-chloro-2-{1-piperazinyl]-pyrazine (MK-212). Br. J. Pharmacol. 62:1978;579-589.
9. Dourish C. T., Rycroft W., Iverson S. D. Postponement of satiety by blockage of brain Cholecystokinin (CCK-B) receptors. Science. 245:1989;1509-1511.
10. Edwards S., Stevens R. Peripherally administered 5-hydroxtryptamine elicits the full behavioural satiety sequence. Physiol. Behav. 50:1991;1075-1077.
11. Halford J. C. G., Blundell J. E. 5-Hydroxytryptaminergic drugs compared on the behavioural satiety sequence. Br. J. Pharmacol. 100:1993;95.
12. Halford J. C. G., Heal D. J., Blundell J. E. Effects in the rat of sibutramine on food intake and the behavioural satiety sequence. Br. J. Pharmacol. 114:1995;387.
13. Halford, J. C. G.: PhD thesis, University of Leeds, Leeds, LS2 9JT UK.
14. Hendrie C. A., Bennett S. A microcomputer technique for the detailed analyses of animal behaviour. Physiol. Behav. 30:1984;233-235.
15. 1C receptor subtype. Neurosci. Lett. 105:1989;174-176.
16. Kirkham T. C., Blundell J. E. Dual action of naloxone on feeding revealed by behavioural analysis. Separate effects on initiation and termination of eating Appetite. 5:1984;45-52.
17. 2 receptor agonists using the post-prandial satiety sequence in rats. Psychopharmacology. 113:1994;369-377.
18. McGuirk J., Muscat R., Willner P. Effects of chronically administered fluoxetine and fenfluramine on food intake, body weight and behavioural satiety sequence. Psychopharmacology. 107:1992;401-407.
19. McGuirk J., Muscat R., Willner P. Effects of the 5-HT uptake inhibitors femoxetine and parpexetine, and the 5-HT1A agonist cltoprazine, on the behavioural satiety sequence. Pharmacol. Biochem. Behav. 41:1992;801-805.
20. Montgomery A. M. J., Willner P. Fenfluramine disrupts the behavioural satiety sequence in rats. Psychopharmacology. 94:1988;397-401.
21. Pöysä H. Measuring time budgets with instantaneous sampling. A cautionary note Animal Behaviour. 40:1991;317-318.
22. Quera V. A generalized technique to estimate frequency and duration in time sampling. Behavioral Assessment. 12:1990;409-424.
23. 2 antagonists in rats. Psychopharmacology. 94:1988;342-364.
24. 1B receptor sub-types in rat frontal cortex. J. Pharmacol. Exp. 231:1984;480-487.
25. Simansky K. J., Vaidya A. H. Behavioural mechanisms for the anorectic actions of the serotonin (5-HT) uptake inhibitor sertraline in rats. Comparison with directly acting agonists Brain Res. Bull. 25:1990;953-960.
26. Willner P., McGuirk J., Phillips G., Muscat R. Behavioural analysis of the anorectic effects of fluoxetine and fenfluramine. Psychopharmacology. 102:1990;273-277.