Changes of cytoskeletal protein immunostaining in myelinated fibre tracts after focal cerebral ischaemia in the rat

Acta Neuropathologica

Volumn 93, Issue 1, 1996, Pages 71-77

  Dewar, Deborah ^a   Dawson, Deborah A ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Focal ischaemia; Microtubules; Rats; White matter

Indexed keywords

CYTOSKELETON PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 5; MICROTUBULE-ASSOCIATED PROTEIN 1B; MTAP1A PROTEIN, RAT; TUBULIN;

ANIMAL; ARTICLE; CHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; MALE; METABOLISM; MYELINATED NERVE; PATHOLOGY; RAT; SPRAGUE DAWLEY RAT; STAINING; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; CYTOSKELETAL PROTEINS; IMMUNOHISTOCHEMISTRY; ISCHEMIC ATTACK, TRANSIENT; MALE; MICROTUBULE-ASSOCIATED PROTEINS; NERVE FIBERS, MYELINATED; RATS; RATS, SPRAGUE-DAWLEY; STAINING AND LABELING; TUBULIN;

EID: 0030636607     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050584     Document Type: Article

References (33)

1. Bartus RT, Baker KL, Heiser AD, Sawyer SD, Dean RL, Elliot PJ, Straub JA (1994) Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage. J Cereb Blood Flow Metabol 14: 537-544
2. Bartus RT, Hayward NJ, Elliot PJ, Sawyer SD, Baker KL, Dean PJ, Akiyama A, Straub JA, Haberson SL, Powers J (1994) Calpain inhibitor AK295 protects neurons from focal cerebral ischemia. Effects of postocclusion intra-arterial administration. Stroke 25: 2265-2270
3. Bartus RT, Dean RL, Cavanaugh K, Eveleth D, Carriero D, Lynch G (1995) Time-related neuronal changes following middle cerebral artery occlusion: implications for therapeutic intervention and the role of calpain. J Cereb Blood Flow Metabol 15: 969-979
4. Billger M, Wallin M, Karlsson J-O (1988) Proteolysis of tubulin and microtubule-associated proteins 1 and 2 by calpain I and II. Difference in sensitivity of assembled and dissassembled microtubules. Cell Calcium 9: 33-44
5. Dawson D, Hallenbeck JM (1996) Acute focal ischemia-induced alterations in MAP2 immunostaining: description of temporal changes and utilization as a marker for volumetric assessment of acute brain injury. J Cereb Blood Flow Metabol 16: 170-174
6. De Camilli P, Miller PE, Navone F, Theurkauf WE, Vallee RB (1984) Distribution of microtubule-associated protein 2 in the nervous system of the rat studied by immunofluorescence. Neuroscience 11 : 819-846
7. Dewar D, Dawson D (1995) Tau protein is altered by focal cerebral ischaemia in the rat: an immunohistochemical and immunoblotting study. Brain Res 684: 70-78
8. Fischer I, Romano-Clarke G, Grynspan F (1991) Calpain-mediated proteolysis of microtubule-associated proteins MAPI B and MAP2 in developing brain. Neurochem Res 8: 891-898
9. Geddes JW, Schwab C, Craddock S, Wilson JL, Pettigrew LC (1994) Alterations in tau immunostaining in the rat hippocampus following transient cerebral ischaemia. J Cereb Blood Flow Metabol 14: 554-564
10. Graham DI, Adams JH, Nicoll JAR, Maxwell WL, Gennarelli TA (1995) The nature, distribution and causes of traumatic brain injury. Brain Pathol 5: 397-406
11. Hamakubo T, Kannagi R, Murachi T, Matus A (1986) Distribution of calpains I and II in rat brain. J Neurosci 6: 3103-3111
12. Hong S-C, Goto Y, Lanzino G, Soleau S, Kassell NF, Lee KS (1994) Neuroproptection with a calpain inhibitor in a model of focal cerebral ischemia. Stroke 24: 663-669
13. Inuzuka T, Tamura A, Sato S, Kirino T, Toyoshima I, Miyatake T (1990) Suppressive effect of E-64c on ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats. Brain Res 526: 177-179
14. Kitagawa K, Matsumoto M, Ninobe M, Mikoshiba K, Hata R, Ueda H, Handa N, Fukunaga R, Isaka Y, Kimura K, Kamada T (1989) Microtubule-associated protein 2 as a sensitive marker for cerebral ischemie damage-immunohistochemical investigation of dendritic damage. Neuroscience 31: 401-411
15. Kuwaki T, Satoh H, Ono T, Shibayama F, Yamashita T, Nishimura T (1989) Nilvadipine attenuates ischemic degradation of gerbil brain cytoskeletal proteins. Stroke 20: 78-83
16. Ludin B, Matus A (1993) The neuronal cytoskeleton and its role in axonal and dendritic plasticity. Hippocampus 3: 61-72
17. Miyazawa T, Bonnekoh P, Hossman K-A (1993) Temperature effect on immunostaining of microtubule-associated protein 2 and synaptophysin after 30 minutes of forebrain ischemia in the rat. Acta Neuropathol 85: 526-532
18. Noble M, Lewis SA, Cowan NJ (1989) The microtubule binding domain of microtubule-associated protein MAPI B contains a repeated sequence motif unrelated to that of MAP2 and tau. J Cell Biol 109: 3367-3376
19. Perlmutter LS, Siman R, Gall C, Seubert P, Baudry M, Lynch G (1988) The ultrastructural localisation of calcium-activated "calpain" in rat brain. Synapse 2: 79-88
20. Povlishock JT (1992) Traumatically induced axonal injury pathogenesis and pathobiological implications. Brain Pathol 2: 1-12
21. Sato-Yoshitake R, Shiomura Y, Miyasaka H, Hirokawa N (1989) Microtubule-associated protein IB: molecular structure, localization and phosphorylation-dependent expression in developing neurons. Neuron 3: 229-238
22. Shiomura N. Hirokawa Y (1987) The molecular structure of microtubule-associated protein 1A (MAP1A) in vivo and in vitro. An immunoelectron microscopy and quick-freeze, deepetch study. J Neurosci 7: 1461-1469
23. Siesjo BK, Karsura K, Pahlmark K, Smith M-L (1992) The multiple causes of ischemic brain damage: a speculative hypothesis. In: Kriegelstein J, Oberpichler-Schwenk H (eds) Pharmacology of cerebral ischemia. Wissenschaftliche Verlagsgesellschaft, Stuttgart, pp 511-525
24. Siman R, Gall C, Perlmutter LS, Christian C. Baudry M, Lynch G (1985) Distribution of calpain I, an enzyme associated with degenerative activity, in rat brain. Brain Res 347: 399-403
25. Tamura A, Graham DI, McCulloch J, Teasdale CM (1981) Focal cerebral ischaemia in the rat: I. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J Cereb Blood Flow Metabol 1: 53-60
26. Tomioka C, Nishioka K, Kogure K (1992) Absence of early destructive changes of cytoskeletal proteins after transient ischemia in the rat. Brain Res 586: 352-357
27. Valle RB (1986) Reversible assembly purification of microtubules without assembly-promoting agents and further purification of tubulin, microtubule-associated proteins and MAP fragments. Methods Enzymol 134: 89-104
28. 2+-mediated injury in CNS white matter. Trends Neurosci 14: 461-468
29. Waxman SG, Black JA, Stys PK, Ransom BR (1992) Ultrastructural concomitants of anoxic injury and early post-anoxic recovery in rat optic nerve. Brain Res 574: 105-119
30. Waxman SG, Black JA, Ransom BG, Stys PK (1993) Protection of the axonal cytoskeleton in anoxic optic nerve by decreased extracellular calcium. Brain Res 614: 137-145
31. 2+-mediated injury in myelinated CNS axons. Brain Res 644: 197-204
32. Yanagihara T, Yoshime T, Morimoto K (1985) Immunohistochemical investigation of cerebral ischemia in gerbils. J Neuropathol Exp Neurol 44: 204-208
33. Yoshime T, Morimoto K, Brengman JK (1985) Immunohistochemical investigation of cerebral ischemia during recirculation. J Neurosurg 63: 922-928