Epidermal N-acetylation of p-aminobenzoyl glutamic acid: Difference in response to ultraviolet B irradiation

Journal of Dermatological Science

Volumn 16, Issue 2, 1998, Pages 99-103

  Kawakubo, Yo ^a   Ohkido, Muneo ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Keratinocyte; N Acetylation; NAT1; NAT2; UVB

Indexed keywords

2 FLUORENYLAMINE; ARYLAMINE ACETYLTRANSFERASE; DRUG METABOLIZING ENZYME; GLUTAMIC ACID DERIVATIVE; ISOENZYME;

ACETYLATION; ARTICLE; CONTROLLED STUDY; ENZYME SUBSTRATE; EPIDERMIS; HUMAN; HUMAN CELL; KERATINOCYTE; NEWBORN; PRIORITY JOURNAL; ULTRAVIOLET B RADIATION;

EID: 0030635249     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-1811(97)00030-3     Document Type: Article

References (20)

1. [1] Hein DW, Doll MA, Rustan TD, et al. Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases. Carcinogenesis 1993;14:1633-8.
2. [2] Hein DW, Doll MA, Rustan TD, Ferguson RJ. Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: effects of seven specific NAT2 nucleic acid substitutions. Cancer Res 1995;55:3531-6.
3. [3] Vatsis KP, Weber WW. Structural heterogeneity of caucasian N-acetyltransferase at the NAT1 gene locus. Arch Biochem Biophys 1993;301:71-6.
4. [4] Weber WW, Vatsis KP. Individual variability in p-aminobenzoic acid N-acetylation by human N-acetyltransferase (NAT1) of peripheral blood. Pharmocogenetics 1993;3:209-12.
5. [5] Kawakubo Y, Manabe S, Yamazoe Y, Nishikawa T, Kato R. Properties of cutaneous acetyltransferase catalyzing N-and O-acetylation of carcinogenic arylamines and N-hydroxyarylamine. Biochem Pharmacol 1988;37:265-70.
6. [6] Kawakubo Y, Yamazoe Y, Nishikawa T, Kato R. High capacity of human skin for N-acetylation of arylamines. Skin Pharmacol 1990;3:180-5.
7. [7] Dietrich A, Kawakubo Y, Rzany B, Mockenhaupt M, Simon JC, Schopf E. Low N-acetylating capacity in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis. Exp Dermatol 1995;4:313-6.
8. [8] Wohlleb JC, Hunter CF, Blass B, Kadlubar FF, Chu DZJ, Lang ND. Aromatic amine acetyltransferase as a marker for colorectal cancer: environmental and demographic associations. Int J Cancer 1990;46:22-30.
9. [9] Kadlubar FF. Biochemical individuality and its implications for drug and carcinogen metabolism: recent insights from acetyltransferase and cytochrome P4501A2 phenotyping and genotyping in humans. Drug Metab Rev 1994;26:37-47.
10. [10] Lang NP, Butler MA, Massengel J, et al. Rapid metabolic phenotype for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increases the risk for colorectal cancer or polyps. Cancer Epidemiol Biomark Prev 1994;3:675-82.
11. [11] Hein DW. Acetylator genotype and arylamine-induced carcinogenesis. Biochim Biophys Acta 1988;948:37-66.
12. [12] Minchin RF. Acetylation of p-aminobenzoylglutamate, a folic acid catabolite, by recombinant human arylamine N-acetyltransferase and U937 cells. Biochem J 1995;307:1-3.
13. [13] Baker BR, Santi DV, Almaula PI, Werkheiser WC. Analogs of tetrahydrofolic acid. X. Synthetic and enzymatic studies on the contribution of the p-aminobenzoyl-L-glutamate moiety of pyrimidyl analogs to binding to some folic cofactor area enzymes. J Med Chem 1964;7:24-30.
14. [14] Gazith J, Cavey MT, Cavey D, Shroot B, Reichert U. Characterization of the β-adrenergic receptors of cultured human epidermal keratinocytes. Biochem Pharmacol 1983;32:3397-403.
15. [15] Kawakubo Y, Iizuka M, Matsuo I, Ohkido M. Ultraviolet irradiation enhances arylamine N-acetyltransferase activity in human keratinocytes. Arch Dermatol Res 1995;287:341-3.
16. [16] Grant DM, Blum M, Beer M, Meyer UA. Monomorphic and polymorphic human arylamine N-acetyltransferases: acomparison of liver isozymes and expressed products of two cloned genes. Mol Pharmacol 1991;39:184-91.
17. [17] Bell DA, Stephens EA, Castranio T, et al. Polyadenilation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer. Cancer Res 1995;55:3537-42.
18. [18] Nakamura H, Uetrecht J, Cribb AK, et al. In vitro formation, disposition and toxicity of N-acetoxy-sulfamethoxazole, a potential mediator of sulfamethoxazole toxicity. J Pharmacol Exp Ther 1995;274:1099-104.
19. [19] Ward A, Hickman D, Gordon JW, Sim E. Arylamine N-acetyltransferase in human red cells. Biochem Pharmacol 1992;44:1099-104.
20. [20] Beck JT, Ullman B. Affinity labeling of the folate-methotrexate transporter from Leishmania donovani. Biochemistry 1989;28:6931-7.