Absorption and metabolism of nivalenol in pigs

Archives of Animal Nutrition

Volumn 50, Issue 1, 1997, Pages 13-24

  Hedman, R ^a   Pettersson, H ^a   Lindberg, J E ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Absorption; Excretion; Feed; Metabolism; Pig; Trichothecenes

Indexed keywords

SUS SCROFA;

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; CHOLESTEROL; GAMMA GLUTAMYLTRANSFERASE; MYCOTOXIN; NIVALENOL; TRICHOTHECENE DERIVATIVE;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; CATHETERIZATION; CHEMISTRY; FECES; GAS CHROMATOGRAPHY; GERMFREE ANIMAL; GLUCOSE BLOOD LEVEL; INTESTINE ABSORPTION; MALE; METABOLISM; METHODOLOGY; PHYSIOLOGY; SPECTROPHOTOMETRY; SWINE; TIME; UREA NITROGEN BLOOD LEVEL;

ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; BLOOD GLUCOSE; BLOOD UREA NITROGEN; CATHETERIZATION, PERIPHERAL; CHOLESTEROL; CHROMATOGRAPHY, GAS; FECES; GAMMA-GLUTAMYLTRANSFERASE; INTESTINAL ABSORPTION; MALE; MYCOTOXINS; SPECIFIC PATHOGEN-FREE ORGANISMS; SPECTROPHOTOMETRY; SWINE; TIME FACTORS; TRICHOTHECENES;

EID: 0030632889     PISSN: 0003942X     EISSN: None     Source Type: Journal    
DOI: 10.1080/17450399709386115     Document Type: Article

References (37)

1. Bauer, J.; Bollwahn, W.; Gareis, M.; Gedek, B. and Heinritzi, K. (1985): Kinetic profiles of diacetoxyscirpenol and two of its metabolites in blood serum of pigs. Appl. Environ Microbiol. 49, 842-845
2. Bauer, J.; Gareis, M. and Gedek, B. (1989): Metabolism of the trichothecenes T-2 toxin, diacetoxyscirpenol, and deoxynivalenol by farm animals. In Fusarium mycotoxins. taxanomy and pathogenicity Topics in Secondary Metabolism 2. pp. 139-165 [J. Chelkowski. editor]. Amsterdam: Elsevier
3. Chatterjee. K.; Pawlosky. R.J.; Treeful. L. and Mirocha C.J. (1986): Kinetic study of T-2 toxin metabolites in a cow. J. Food Safety 8, 25-34
4. Corley, R.A.; Swanson, S.P. and Buck, W.B. (1985): Glucuronide conjugates of T-2 toxin and metabolites in swine bile and urine. J. Ayric Food Chem. 33, 1085-1089
5. Corley, R.A.; Swanson, S.P.; Gullo, G.J.; Johnson, L.; Beasley, V.R. and Buck, W.B. (1986): Disposition of T-2 toxin, a trichothecene mycotoxin, in intravascularly dosed swine. J. Agric. Food. Chem. 34, 868-875
6. Côté, L.M.; Buck, W. and Jeffery, E. (1987): Lack of hepatic microsomal metabolism of deoxynivalenol and its metabolite, DOM-1, Food Chem Toxicol. 25, 291-295
7. Doerr, J.A.; Huff, W.E.; Tung, H.T.; Wyatt, R.D. and Hamilton, P.B. (1974): A survey of T-2 toxin, ochratoxin, and aflatoxin for their effects on the coagulation of blood in young broiler chickens. Poult. Sci 53, 1728-1734
8. Forsyth, D.M.; Yoshizawa, T.; Morooka, N. and Tuite, J. (1977): Emetic and refusal activity of deoxynivalenol to swine. Appl. Environ. Microbiol. 34, 547-552
9. Fuller, R, (1992): Probiotics. The Scientific Basis London. Chapman and Hall
10. He, P.; Young, L.G. and Forsberg, C. (1992): Microbial transformation of deoxynivalenol (vomitoxin). Appl Environ. Microbiol. 58, 3857-3863
11. Hedman, R.; Pettersson, H.; Engström, B.; Elwinger, K. and Fossum, O. (1995): Effects of feeding nivalenol-contaminated diets to male broiler chickens. Poult. Sci. 74, 620-625
12. Huff, W.E.; Doerr, J.A.; Hamilton, P.B. and Vesonder, R.F. (1981): Acute toxicity of vomitoxin (Deoxynivalenol) in broiler chickens. Poult Sci. 60, 1412-1414
13. Kaneko, J.J. (1980): In Clinical Biochemistry of Domestic Animals. 3rd Ed., pp. 792-797 [JJ. Kaneko, ed.]. New York: Academic Press
14. Kollarczik, B.; Gareis, M. and Hanelt, M. (1994): In vitro transformation of the Fusarium mycotoxins deoxynivalenol and zearalenone by the normal gut microflora of pigs. Natural Toxins 2. 105-110
15. Marasas, W.F.O.; Nelson, P.E. and Tousson, T.A. (1984): Toxigenic Fusarium Species. University Park, PA: Pensylvania State University Press
16. Onji, Y.; Dohi, Y.; Aoki, Y.; Moriyama, T.; Nagami, H.; Uno, M.; Tanaka, T. and Yamazoe, Y. (1989): Deepoxynivalenol: A new metabolite of nivalenol found in the excreta of orally administered rats. J. Agric. Food Chem. 37, 478-481
17. Patterson, D.S.; Matthews, J.G.; Shreeve, B.J.; Roberts, B.A.; McDonald, S.M. and Hayes. A.W. (1979): The failure of trichothecene mycotoxins and whole cultures of Fusarium tricinctum to cause experimental haemorrhagic syndromes in calves and pigs. Vet Rec. 105, 252-255
18. Pestka, J.J.; Lin, W.S. and Miller, E.R. (1987): Emetic activity of the trichothecene 15-acetyldeoxynivalenol in swine. Food Chem. Toxicol. 25, 855-858
19. Pettersson, H. (1991): Nivalenol production by Fusarium poae. Mycotox. Res. 7, 26-30
20. Pettersson, H. (1993): Trichothecene analysis in Swedish cereals 1987-1990. Hod. Rosl. Aklim. Nasien. (Spec. Ed. Proc. 3rd European Seminar on Fusarium) 37, 37-41
21. Prelusky, D.B.; Hamilton, R.M.; Trenholm, H.L. and Miller, J.D. (1986a): Tissue distribution and excretion of radioactivity following administration of 14C-labelled deoxynivalenol to White Leghorn hens. Fundam. Appl. Toxicol. 7, 635-645
22. Prelusky, D.B.; Hartin, K.E.; Trenholm, H.L. and Miller, J.D. (1988): Pharmacokinetic fate of 14C-labelled deoxynivalenol in swine. Fundam. Appl Toxicol. 10, 276-286
23. Prelusky, D.B.; Trenholm, H.L.; Lawrence, G.A. and Scott, P.M. (1984): Nontransmission of deoxynivalenol (vomitoxin) to milk following oral administration to dairy cows. J Environ Sci Health 19, 593-609
24. Prelusky, D.B.; Veira, D.M. and Trenholm, H.L. (1985): Plasma pharmacokinetics of the mycotoxin deoxynivalenol following oral and intravenous administraion to sheep. J Environ. Sci Health 20, 603-624
25. Prelusky, D.B.; Veira, D.M.; Trenholm, H.L. and Hartin. K.E. (1986b): Excretion profiles of the mycotoxm deoxynivalenol, following oral and intravenous administration to sheep. Fundam. Appl Toxicol. 6, 356-363
26. Rood, H.D.J.; Buck, W.B. and Swanson, S.P. (1988): Diagnostic screening method for the determination of trichothecene exposure in animals. J Agric Food Chem. 36, 74 - 79
27. Sakamoto, T.; Swanson, S.P.; Yoshizawa, T. and Buck, W.B. (1986): Structures of new, metabolites of diacetoxyscirpenol in the excreta of orally administred rats. J Agric. Food. 34, 698-701
28. Swanson, S.P.; Helaszek, C.; Buck, W.B.; Rood, H.D. Jr. and Haschek, W.M. (1988): The role of intestinal microflora in the metabolism of trichothecene mycotoxins. Food Chem. Toxicol. 26, 823-829
29. Takitani, S.; Asabe, Y.; Kato, T.; Suzuki, M. and Ueno, Y. (1979): Spectrodensitometric determination of trichothecene mycotoxins with 4-(p-nitrobenzyl)pyridine on silica gel thin-layer chromatograms. J. Chromatogr. 172, 335-342
30. Trenholm, H.L.; Friend, D.W.; Hamilton, R.M.G.; Prelusky, D.B. and Foster, B.C. (1989): Lethal toxicity and nonspecific effects. In: Tricliothecvne mycotoxicosis pathophysiologic effects I, pp. 107-141. [V.R. Beasley, ed.]. Boca Raton, Florida: CRC Press
31. Ueno, Y.; (1983) Effect of trichothecene mycotoxins on farm animals. In Trichothecenes Chemical, biological und texicological aspects pp. 135-146 [Y. Ueno, ed.]. Amsterdam: Elsevier
32. Ueno, Y.; Lee, U.S.; Tanaka. T.; Hasegawa, A. and Matsuki, Y. (1986): Examination of Chinese and U.S.S.R. cereals for the Fusarium mycotoxins. nivalenol, deoxynivalenol and zearalenone. Toxicon. 24, 618-621
33. Weaver, G.A.; Kurtz, H.J.; Bates, F.Y.; Mirocha, C.J.; Behrens. J.C. and Hagler, W.M. (1981): Diacetoxyscirpenol toxicity in pigs. Res. Vet. Sci. 31, 131-135
34. Weaver, G.A.; Kurtz, H.J.; Mirocha, C.J.; Bates, F.Y.; Behrens, J.C.; Robison, T.S. and Swanson, S.P. (1980): The failure of purified T-2 mycotoxin to produce hemorrhaging in dairy cattle. Can. Vet. J. 21, 210-213
35. Worrell, N.R.; Mallett, A.K.; Cook, W.M.; Baldwin, N.C. and Shepherd, M.J. (1989): The role of gut micro-organisms in the metabolism of deoxynivalenol administered to rats. Xenobiotica 19, 25-32
36. Yoshizawa, T.; Sakamoto, T. and Kuwamura, K. (1985): Structures of deepoxytrichothecene metabolites from 3'-hydroxy HT-2 toxin and T-2 tetraol in rats. Appl. Environ Microbiol. 50, 676-679
37. Yoshizawa, T.; Takeda, H. and Ohi, T. (1983): Structure of a novel metabolite from deoxynivalenol, a trichothecene mycotoxin. in animals. Agric. Biol. Chem. 47, 2133-2135