DNA Synthesis and Cell Proliferation in C6 Glioma and Primary Glial Cells Exposed to a 836.55 MHz Modulated Radiofrequency Field

Bioelectromagnetics

Volumn 18, Issue 3, 1997, Pages 230-236

  Stagg, Robert B ^a,b   Thomas, William J ^a   Jones, Robert A ^a   Adey, W Ross ^a  

^a Jerry L Petits Mem Vet AMC   (United States)

^b Jerry L Pettis Memorial VA Medical Center   (United States)

Author keywords

Brain tumor; Electromagnetic fields; Tumor promotion

Indexed keywords

BODY FLUIDS; CELLULAR TELEPHONES; DNA; ELECTROMAGNETIC FIELDS; RATS; TISSUE CULTURE; TUMORS;

BRAIN TUMORS; CELL-BE; CELL/B.E; CELL/BE; DNA SYNTHESISS; EXPOSED TO; GLIAL CELLS; RADIO FREQUENCY FIELDS; SPECIFIC ABSORPTION RATE; TUMOR PROMOTION;

CELL PROLIFERATION;

DNA;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; CULTURE MEDIUM; CYTOLOGY; DNA REPLICATION; ELECTROMAGNETIC FIELD; GLIA; GLIOMA; KINETICS; PHYSIOLOGY; RADIATION EXPOSURE; RADIOFREQUENCY RADIATION; RAT;

ANIMALS; CELL DIVISION; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; DNA; DNA REPLICATION; DNA, NEOPLASM; ELECTROMAGNETIC FIELDS; GLIOMA; KINETICS; NEUROGLIA; RADIO WAVES; RATS; TUMOR CELLS, CULTURED;

EID: 0030632777     PISSN: 01978462     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-186X(1997)18:3<230::AID-BEM5>3.0.CO;2-3     Document Type: Article

References (24)

1. Adey WR (1989): Electromagnetic fields, cell membrane amplification, and cancer promotion. In Wilson BW, Stevens RG eds). "Extremely Low Frequency Electromagnetic Fields." Washmgton: Batelle Press, pp 211-249.
2. Adey WR (1990): Joint action of environmental nonionizing electro- magnetic fields and chemical pollution in cancer promotion. Environ Health Perspect 86:297-305.
3. Ames BN, Gold LS (1990): Chemical carcinogenesis: Too many rodent carcinogens. Proc Natl Acad Sci USA 87:7772-7776.
4. Bawin SM, Kaczmarek LK, Adey WR (1975): Effects of modulated VHF fields on the central nervous system. Ann NY Acad Sci 247:74-81.
5. Blackman CF, Kinney LS, House DE, Joines WT (1989): Multiple power density windows and their possible origin. Bioelectromagnetics 10:115-128.
6. Bohr V, Køber L (1985): DNA repair in lymphocytes from patients with secondary leukemia as measured by strand rejoining and unscheduled DNA synthesis. Mutat Res 146:219-225.
7. Burkhardt M, Poković K, Gnos, M, Schmid T, Kuster N (1996): Numerical and experimental dosimetry of petri dish exposure setups. Bioelectromagnetics 17:483-493.
8. Byus CV, Kartun K, Pieper S, Adey WR (1988): Increased ornithine decarboxylase activity in cultured cells exposed to low energy modulated microwave fields and phorbol ester tumor promoters. Cancer Res 48:4222-4226.
9. Cain CD, Adey WR, Luben RA (1987): Evidence that pulsed electromagnetic fields inhibit coupling of adenylate cyclase by parathyroid hormone in bone cells. J Bone Mineral Res 2:437-441.
10. Cain CD, Thomas DL, Adey WR (1993): 60 Hz magnetic field acts as copromoter in focus formation of C3H/10T1/2 cells. Carcinogen 14:955-960.
11. Cleary SF, Li-Ming L, Merchant RE (1990a): In vitro lymphocyte proliferation induced by radio-frequency electromagnetic radiation under isothermal conditions. Bioelectromagnetics 11:47-56.
12. Cleary SF, Li-Ming L, Merchant RE (1990b): Glioma proliferation modulated in vitro by isothermal radiofrequency radiation exposure. Radiat Res 121:38-45.
13. Diamond L, O'Brien S, Donaldson C, Shimizu Y (1974): Growth stimulation of human diploid fibro-blasts by the tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate. Int J Cancer 13:721-730.
14. Fitzsimmons RJ, Farley JR, Adey WR, Bay link DJ (1989): Frequency dependence of increased cell proliferation, in vitro, in exposure to a low-amplitude, low-frequency electric field: Evidence for dependence on increased mitogenic activity released into culture medium. J Cell Physiol 139:586-591.
15. Gospodarowicz D, Greenburg G, Bralecki H, Zetter BR (1978): Factors involved in the modulation of cell proliferation in vivo and in vitro: The role of fibroblast and epidermal growth factors in the proliferative response of mammalian cells. In Vitro 14:85-118
16. Ivaschuk OI, Jones RA, Ishida-Jones T, Haggren W, Adey WR, Phillips (1996): Exposure of nerve growth factor-treated PC 12 rat pheochromocytoma cells to a modulated radiofrequency field at 836.55 Mhz: Effects on c-jun and c-fos expression. Bioelectromagnetics 18:223-229.
17. Lai H, Singh NP (1995): Acute low-intensity microwave exposure increases DNA single-strand breaks in rat brain cells. Bioelectromagnetics 16:207-210.
18. Liboff AR, Williams T, Strong DM, Wistar R (1984): Time-varying magnetic fields: Effect on DNA synthesis. Science 223:818-820.
19. Peterson AR, Mondal S, Brankow DW, Thon W, Heidelberger C (1977): Effects of promoters on DNA synthesis in C3H/10T1/3 mouse fibroblasts. Cancer Res 37:3223-3227.
20. Pitot HC, Dragan YP (1991): Facts and theories concerning the mechanism of carcinogenesis, FASEB J 5:2280-2286.
21. Preston-Martin S, Mack W, Henderson BE (1989): Risk factors for gliomas and meningiomas in males in Los Angles County. Cancer Res 49:6137-6143.
22. Ross SM (1990): Combined DC and ELF magnetic fields can alter cell proliferation. Bioelectromagnetics 11:27-36.
23. Thomas TL, Stolle PD, Stemhagen A, Fontham ETH, Bleecker ML Stewart PA, Hoover RN (1987): Brain tumor mortality risks among men with electrical and electronic jobs: A case-controlled study. JNCI 79:233-237.
24. Walleczek J (1992): Electromagnetic field interactions with cells of the immune system: The role of calcium signaling. FASEB 6:3177-3185.