No increase of ornithine concentration in the liver of ornithine transcarbamylase-deficient spf-ash mice following intraperitoneal injection of ammonium chloride

Contributions to Nephrology

Volumn 121, Issue , 1997, Pages 109-116

  Saheki, Takeyori ^a   Fukushige, Tomoko ^a   Kakinoki, Hiroshige ^a   Kobayashi, Keiko ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; AMMONIUM CHLORIDE; ARGININE; CITRULLINE; ORNITHINE; ORNITHINE CARBAMOYLTRANSFERASE; OROTIC ACID; PEPTONE; TRYPTONES;

ANIMAL; ARTICLE; DRUG EFFECT; ENZYMOLOGY; GENETICS; LIVER; METABOLISM; MOUSE; MOUSE STRAIN; TRANSGENIC MOUSE;

AMMONIA; AMMONIUM CHLORIDE; ANIMALS; ARGININE; CITRULLINE; LIVER; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; ORNITHINE; ORNITHINE CARBAMOYLTRANSFERASE; OROTIC ACID; PEPTONES;

EID: 0030629871     PISSN: 03025144     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (25)

1. Krebs HA, Henseleit K: Untersuchungen über die Harnstoffbildung im Tierkörper. Hoppe Seylers Z Physiol Chem 1932;210:33-66.
2. Saheki T, Katsunuma T, Sase M: Regulation of urea synthesis in rat liver. Changes of ornithine and acetylglutamate concentrations in the livers of rats subjected to dietary transitions. J Biochem 1977;82:551-558.
3. Saheki T, Ohkubo T, Katsunuma T: Regulation of urea synthesis in rat liver. Increase in the concentrations of ornithine and acetylglutamate in rat liver in response to urea synthesis stimulated by the injection of ammonium salt. J Biochem 1978;84:1423-1430.
4. Saheki T, Ueda A, Hosoya M, Katsunuma T, Ohnishi N, Ozawa A: Comparison of the urea cycle in conventional and germ-free mice. J Biochem 1980;88:1563-1566.
5. Hayase K, Yokogoshi H, Yoshida A: Effect of dietary proteins and amino acid deficiencies on urinary excretion of nitrogen and the urea-synthesizing system in rats. J Nutr 1980;110:1327-1337.
6. Saheki T, Mori K, Kobayashi K, Horiuchi M, Shige T, Obara T, Suzuki S, Mori M, Yamamura K: Importance of ornithine transcarbamylase (OTC) deficiency in small intestine for urinary orotic acid excretion: Analysis of OTC-deficient spf-ash mice with OTC transgene. Biochim Biophys Acta 1995;1270:87-93.
7. Shimada T, Noda T, Tashiro M, Murakami T, Takiguchi M, Mori M, Yamamura K, Saheki T: Correction of ornithine transcarbamylase (OTC) deficiency in spf-ash mice by introduction of rat OTC gene. FEBS Lett 1991;279:198-200.
8. Murakami T, Takiguchi M, Inomoto T, Yamamura K, Mori M: Tissue- and development stage-specific expression of the rat ornithine carbamoyltransferase gene in transgenic mice. Dev Genet 1989;10:3993-4001.
9. Kobayashi K, Horiuchi M, Yokokouji A, Shimada T, Saheki T: Simultaneous detection of mutant gene and transgene in ornithine carbamoyltransferase- deficient spf-ash mice with rat OCT gene. J Inherit Metab Dis 1992;15:792-796.
10. Qi SL, Akagi K, Araki K, Miyazaki J, Yamamura K: Rapid indentification of transgenic mice with PCR amplification of DNA from ear punching. Methods Mol Biol 1991;2:119-122.
11. Svensson G, Anfält T: Rapid determination of ammonia in whole blood and plasma using flow injection analysis. Clin Chim Acta 1982;119:7-14.
12. Kesner L, Aronson FL, Silverman M, Chan PC: Determination of orotic and dihydroorotic acids in biological fluids and tissues. Clin Chem 1975;21:353-355.
13. Bonsnes RW, Taussky HH: On the colorimetric determination of creatinine by Jaffe reaction. J Biol Chem 1945;158:581-591.
14. Windmueller HG, Spaeth AE: Source and fate of circulating citrulline. Am J Physiol 1981;241:E473-E480.
15. Hartman WJ, Prior RL: Dietary arginine deficiency alters flux of glutamine and urea cycle intermediates across the portal-drained viscera and liver of rats. J Nutr 1992;122:1472-1482.
16. 15N] ammonia into plasma amino acids and urea. Am J Physiol 1995;269:E508-E515.
17. Rubio V, Grisolia S: Human earbamoylphosphate synthetase I. Enzyme 1981;26:233-239.
18. Milner JA, Visek WJ: Orotic aciduria and arginine deficiency. Nature 1973;245:211-213.
19. Morris JG, Rogers QR: Ammonia intoxication in the near-adult cat as a result of a dietary deficiency of arginine. Science 1978;199:431-433.
20. Burns RA, Milner JA, Corbin JE: Arginine, an indispensable amino acid for mature dogs. J Nutr 1981;111:1020-1024.
21. Deshmukh DR, Sarnaik AP, Mukhopadhyay A, Portoles M: Effect of arginine-free diet on plasma and tissue amino acids in young and adult ferrets. J Nutr Biochem 1991;2:72-78.
22. Carey GP, Kime Z, Rogers QR, Morris JG, Hargrove D, Buffington CA, Brusilow SW: An arginine-deficient diet in humans does not evoke hyperammonemia or orotic aciduria. J Nutr 1987;117:1734-1739.
23. Yamada E, Wakabayashi Y, Saito A, Yoda K, Tanaka Y, Miyazaki M: Hyperammonemia caused by essential amino acid supplements in patient with short bowel. Lancet 1993;341:1542-1543.
24. Wakabayashi Y, Yamada E, Yoshida T, Takahashi H: Arginine becomes an essential amino acid after massive resection of rat small intestine. J Biol Chem 1994;269:32667-32671.
25. Nelson J, Qureshi IA, Vasudevan S, Sarma DSR: The effect of various inhibitors on the regulation of orotic acid excretion in sparse-fur mutant mice (spf/Y) deficient in ornithine transcarbamylase. Chemicobiol Interact 1993;89:35-47.