Genetic manipulation of Streptomyces, the basis for the production of new antibiotics;Streptomycetengenetik, Grundlage fur die Herstellung neuer Antibiotika

Pharmazie in Unserer Zeit

Volumn 26, Issue 1, 1997, Pages 12-16

  Bechtold, Andreas ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CLARITHROMYCIN; ERYTHROMYCIN; ERYTHROMYCIN ETHYLSUCCINATE; MIDECAMYCIN; PAROMOMYCIN; SPIRAMYCIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ARTICLE; BACTERIAL MUTATION; CHEMICAL MODIFICATION; DRUG ISOLATION; DRUG SYNTHESIS; GENETIC TRANSFORMATION; MOLECULAR CLONING; NONHUMAN; STREPTOMYCES; BIOSYNTHESIS; GENETICS; METABOLISM; REVIEW; STREPTOMYCETACEAE;

ANTI-BACTERIAL AGENTS; STREPTOMYCETACEAE;

EID: 0030627530     PISSN: 00483664     EISSN: None     Source Type: Journal    
DOI: 10.1002/pauz.19970260107     Document Type: Article

References (22)

1. Gräfe, U.: Biochemie der Antibiotika. Spektrum Akademischer Verlag. Heidelberg, Berlin, New York 1992.
2. Henkel, T. and Rohr, J.: Landomycins, new angucyline antibiotics from Streptomyces SP, J. Antibiotics 43 (1990), 492-503.
3. Buzetti, F., Eisenberg, F.; Grant, H.N., Keller-Schierlein, W., Voser, W. and Zähner, H.: Avilamycin, Experientia 24 (1968), 320-323.
4. Katz, L., Hutchinson, R.: Genetic engeneering of antibiotic producing organisms, Annual reports in medicinal chemistry 27 (1992), 129-138.
5. Bibb, M.J., Ward, J.M. and Hopwood, D.A.: Transformation of plasmid DNA into Streptomyces protoplasts at high frequency, Nature 274 (1978), 398-400.
6. Bibb, M. J., Schottel, J.L. and Cohen, S.N.: A DNA cloning system for interspecies gene transfer in antibiotic producing Streptomyces, Nature 284 (1980), 526-528.
7. Hopwood, D.A., Bibb, M. J., Chater, K. F., Kieser, T., Bruton, C. J., Kieser, H. M., Lydiate, D. J., Smith, C.P., Ward, J. M., Schrempf, H.: Genetic manipulation of Streptomyces - a laboratory manual. The John Innes Foundation. Norwich, England 1985.
8. Rohr, J.: Kombinatorische Biosynthese - eine Zukunftstrategie, Angew. Chem. 107 (1995), 963-966.
9. McAlpine, J.B., Tuan, J.S., Brown, D.P., Grebner, K.B., Whittern, D.N., Buko, A. and Katz, L.: New antibiotics from genetically engineered actinomycetes. I. 2-Norerythromycins, isolation and structural determinations, J. Antibiotics 40 (1987), 1115-1122.
10. Weber, J. M., Leung, J.O., Swanson, S.J., Idler, K.B. and McAlpine, J.B.: An erytromycin derivate produced by targeted gene disruption in Saccharopolyspora erythraea, Sciences 252 (1991), 114-117.
11. Donadio, S., McAlpine, J.B., Sheldon, P.J., Jackson, M. and Katz, L.: An erythromycin analog produced by reprogramming of polyketide synthesis, Proc. Natl. Acad. Sci. USA 90 (1993), 7119-7123.
12. Epp, J.K., Huber, M.L.B., Turner, J.R., Goodson, T. and Schoner, B.E.: Production of hybrid macrolide antibiotics in Streptomyces ambofaciens and Streptomyces lividans by introduction of a cloned carbomycin biosynthetic gene from Streptomyces thermotolerans, Gene 85 (1989), 293-301.
13. Hara, O. and Hutchinson, C.R.: A macrolide 3-O-acyltransferase gene from the midecamycin-producing Streptomyces mycarofaciens, J. Bacteriol. 174 (1990), 5141-5144.
14. Hopwood, D.A., Sherman, D.H.: Molecular genetics of polyketides and its comparison to fatty acid biosynthesis, Annu. Rev. Genet. 24 (1990), 37-66.
15. Katz, L. Donadio, S.: Polyketide synthesis: Prospects for hybrid antibiotics, Annu. Rev. Microbiol. 47 (1993), 875-912.
16. Hopwood, D.A., Malpartida, F., Kieser, H.M., Ikeda, H., Duncan, J., Fuji, I., Rudd, A.M., Floss, H.G. and Omura, S.: Production of "hybrid" antibiotics by genetic engineering, Nature 314 (1985), 642-644.
17. Stachelhaus, T., Schneider, A., Marahiel, M.A.: Rational design of peptid antibiotics by targeted replacement of bacterial and fungal domains, Science 269 (1995), 69-72.
18. Fu, H., Ebert-Khosla, S., Hopwood, D.A., Khosla, C.: Engineered biosynthesis of novel polyketides: Dissection of the catalytic specificity of the act ketoreductase, J. Am. Chem. Soc. 116 (1994), 4166-4170.
19. McDaniels, R., Ebert-Khosla, S., Hopwood, D.A., Khosla, C.: Engineered biosynthesis of novel polyketides, Science 262 (1993), 1546-1550.
20. Bechtold, A., Sohng, J.K., Smith, T.M., Chu, X., Floss, H.G.: Identification of Streptomyces violaceoruber Tü22 genes involved in the biosynthesis of granaticin, Mol. Gen. Genet. 248 (1995), 610-620.
21. Liu, H.-w., Thorson, J.S.: Pathways and mechanisms in the biogenesis of novel desoxysugars by bacteria, Annu. Rev. Microbiol. 48 (1994), 223-256.
22. Kutchan, T.M.: Alkaloid biosynthesis - the basis for metabolic engineering of medicinal plants, The Plant Cell 7 (1995), 1059-1070.