Effect of heparin on megakaryocytopoiesis: From fundamental studies to clinical applications;Effects de l'heparine sur la megacaryocytopoiese. Des donnees fondamentales aux applications cliniques

Annales de Medecine Interne

Volumn 148, Issue 2, 1997, Pages 150-153

  Bellucci, Sylvia ^b   Han, Zhong Chao ^b   Caen, Jacques ^a  

^a HÔPITAL LARIBOISIÈRE   (France)

^b NONE

Author keywords

heparin; interleukin 6; megakaryocytopoiesis; platelet factor 4; thrombopoietin

Indexed keywords

CYTOKINE; FLUOROURACIL; HEPARIN; NADROPARIN;

CONFERENCE PAPER; DRUG MECHANISM; HEMATOPOIESIS; HUMAN; MEGAKARYOCYTE; THROMBOCYTOPENIA; ANIMAL; CELL CULTURE; CELL DIVISION; CYTOLOGY; MOUSE; PHYSIOLOGY; REVIEW; STIMULATION;

ANIMALS; CELL DIVISION; CELLS, CULTURED; CYTOKINES; HEPARIN; HUMANS; MEGAKARYOCYTES; MICE; STIMULATION, CHEMICAL;

EID: 0030625959     PISSN: 0003410X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (30)

1. VAINCHENKER W, DEBILI N, METHIA N, WENDLING F : Le ligand de Mpl (thrombopoïétine) et régulation de la production plaquettaire. Hématologie 1995 ; 2 : 89-105.
2. HOVIG T : Megakaryocyte and platelet morphology. Platelet disorders. Clin Haematol Baillière's 1989 ; 2 : 503-9.
3. ELDOR A, VLODAVSKY I, DEUTSCH V, LEVINE RF : Megakaryocyte function and dysfunction. Platelet disorders. Clin Haematol Baillère's 1989 ; 2 : 543-68.
4. DE SAUVAGE FJ, HASS PE, SPENCER et al : Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 1994 ; 369 : 533-8.
5. LOK S, KAUSHANSKY K, HOLLY RD et al : Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 1994 ; 369 : 565-8.
6. BARTLEY TD, BOGENBERGER J, HUNT P et al : Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 1994 ; 77 : 1117-24.
7. DEBILI N, WENDLING F, KATZ A et al : The Mpl-ligand or thrombopoietin or megakaryocyte growth and development factor has both direct proliferative and differentiation activities on human megakaryocyte progenitors. Blood 1995 ; 86 : 2516-25.
8. STEAD RB, HARKER LA : Preclinical studies and potential clinical applications of c-Mpl ligand. Curr Opin Hematol 1996 ; 3 : 197-202.
9. CAEN JP, HAN ZC : Megakaryocyte differentiation : positive and negative regulation. Cell Res 1995 ; suppl : 23-32.
10. GEWIRTZ AM, ZHANG J, RATAJCZAK J et al : Chemokine regulation of megakaryocytopoiesis. Blood 1995 ; 86 : 2559-67.
11. GANSER A, CARLO-STELLA C, GREHER J et al : Effect of recombinant interferon alpha and gamma on human bone marrow-derived megakaryocytic progenitor cells. Blood 1987 ; 70 : 1173-9.
12. WADENVIK H, KUTTI J, RIDELL B et al : The effect of α-interferon on bone marrow megakaryocytes and platelet production rate in essential thrombocythemia. Blood 1991 ; 77 : 2103-8.
13. ROBERTS R, GALLAGHER J, SPOONCER E, ALLEN TD, BLOOMFIELD F, DEXTER TM : Heparan sulfate bound growth factors ; a mechanism for stroma cell mediated haemopoiesis. Nature 1988 ; 332 : 376-8.
14. RUOSLAHTI E, YAMAGUCHI Y : Proteoglycans as modulator of growth factor activities. Cell 1991 ; 64 : 867-9.
15. GORDON MY, RILEY GP, WATT SM, GREAVES MF : Compartmentalization of a haematopoietic growth factor (GM-CSF) by glycosaminoglycans in the bone marrow microenvironnement. Nature 1987 ; 326 : 403-5.
16. HAN ZC, BELLUCCI S, SHEN ZX et al : Glycosaminoglycans enhance megakaryocytopoiesis by modifying the activities of hematopoietic growth regulators. J Cell Physiol 1996 ; 168 : 97-104.
17. HAN ZC, MAURER AM, BELLUCCI S et al : Inhibitory effect of platelet factor 4 (PF4) on the growth of human erythroleukemia cells : proposed mechanism of action of PF4. J Lab Clin Med 1992 ; 120 : 645-60.
18. CHOI ES, NICHOL JL, HOKOM MM, HORNKOHL AC, HUNT P : Platelet generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood 1995 ; 85 : 402-13.
19. MAURER AM, HAN ZC, DHERMY D, BRIERE J : Inhibitory effect of platelet factor 4 on human erythroleukemic cells is dependent on cell surface heparan sulfate. J Lab Clin Med 1996 ; 127 : 382-90.
20. TAJIKA K, IKEBUCHI K, DAN K, ASANO S : A role of GAGs in ECM on morphogenesis of megakaryocytes. Br J Haematol 1996 ; 94 : 34-9.
21. SHEN ZX, BASARA N, XI XD et al : Fraxiparin, a low molecular weight heparin, stimulate megakaryocytopoiesis in vitro and in vivo in mice. Br J Haematol 1994 ; 88 : 608-12.
22. BELLUCCI S : Autoimmune thrombocytopenias. Clin Haematol Baillière's 1989 ; 2 : 695-728.
23. SHEN ZX, LI JM, WANG ZY, HAN ZC, CAEN JP, BELLUCCI SA : Thrombocytopoietic effect of heparin given in chronic immune thrombocytopenic purpura. Lancet 1995 ; 346 : 220-1.
24. EMMONS RVB, REID DM, COHEN RL et al : Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 1996 ; 87 : 4068-71.
25. EMMONS RVB, REID DM, COHEN RL et al : Human thrombopoietin levels are high when thrombocytopenia is due megakaryocyte deficiency and low when due to increased platelet destruction. Blood 1996 ; 87 : 4068-71.
26. ICHIKAWA N, ISHIDA F, SHIMODAIRA S, TAHARA T, KATO T, KITANO K : Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anaemia and idiopathic thrombocytopenic purpura. Throm Haemost 1996 ; 76 : 156-60.
27. KOSUGI S, KURATA Y, TOMIYAMA Y et al : Circulating thrombopoietin level in chronic immune thrombocytopenic purpura. Br J Haematol 1996 ; 91 : 704-6.
28. FIELDER PJ, GURNEY AL, STEFANICH E et al : Regulation of thrombopoietin levels by c-Mpl-mediated binding to platelets. Blood 1996 ; 87 : 2154-61.
29. KUTER DJ, ROSENBERG R : The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 1995 ; 85 : 2720-30.
30. OR R, NAGLER A, SHPILBERG O et al: Low molecular weight heparin for the prevention of veno-occlusive disease of the liver in bone marrow transplantation patients. Transplantation 1996 ; 61 : 1067-71.