6. prune/Killar of prune: A Conditional Dominant Lethal Interaction in Drosophila

Advances in Genetics

Volumn 35, Issue C, 1997, Pages 207-252

  Timmons, Lisa ^a   Shearn, Allen ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABNORMAL WING DISCS PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; DROSOPTERIN; INSECT PROTEIN; NUCLEOSIDE DIPHOSPHATE KINASE; PRUNE PROTEIN, DROSOPHILA; PTERIDINE DERIVATIVE;

ALLELE; ANIMAL; BIOLOGICAL MODEL; DOMINANT GENE; DROSOPHILA; FEMALE; GENE; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; LETHAL GENE; MALE; METABOLISM; MUTATION; PHENOTYPE; REVIEW;

ALLELES; ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, DOMINANT; GENES, INSECT; GENES, LETHAL; INSECT PROTEINS; MALE; MODELS, GENETIC; MUTATION; NUCLEOSIDE-DIPHOSPHATE KINASE; PHENOTYPE; PTERIDINES;

EID: 0030624791     PISSN: 00652660     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2660(08)60451-4     Document Type: Article

References (166)

1. Agarwal K.C., Miech R.P., and Parks Jr. R.E. Guanylate kinases from human erythrocytes, hog brain, and rat liver. Methods Enzymol. 51 (1978) 483-490
2. Alcathiz S., Ruiz-Vazquez P., and Silva F.J. Evidence of the phenylalanine hydroxylase involvement in biosynthesis of pteridines and hydroxylation of tryptophan in Drosophila melanogaster. Ptridines 6 (1995) 135-137
3. Almaula N., Lu Q., Delgado J., Belkin S., and Inouye M. Nucleoside diphosphate kinase from Escherichia coli. J. Bacteriol. 177 (1995) 2524-2529
4. Amaya Y., Yamazaki K., Sato M., Noda K., Nishino T., and Nishino T. Proteolytic conversion of xanthine dehydrogenase from the NAD-dependent type to the O2-dependent type: Amino acid sequence of rat liver xanthine dehydrogenase and identification of the cleavage sites of the enzyme protein during irreversible conversion by trypsin. J. Biol. Chem. 265 24 (1990) 14170-14175
5. Baker W.K. New mutants report. Drosophila information Service 30 (1956) 69
6. Barnes R., Masood S., Barker E., Rosengard A.M., Coggin D.L., Crowell T., Richter-King C., Porter-Jordan K., Wargotz E.S., Liotta L.A., and Steeg P.S. Low Nm23 protein expression in infiltrating ductal breast carcinomas correlates with reduced patient survival. Am. J. Pathol. 139 (1991) 245-251
7. Beadle G.W., and Ephrussi B. The differentiation of eye pigments in Drosophila as studied by transplantation. Genetics 21 (1936) 225-247
8. Beadle G.W. Development of eye colors in Drosophila: Fat bodies and Malpighian tubes as sources of diffusible substances. Genetics 22 (1937) 587-611
9. Becker J.L. Regulation of purine biosynthesis in cultured Drosophila melanogaster cells: I.-Conditional activity of hypoxanthine-guanine-phosphoribosyltransferase and 5′ nucleotidase. Biochemie 60 (1978) 619-625
10. Becker J.L. Regulation of purine biosynthesis in cultured Drosophila melanogaster cells: II. Relationships between hypoxanthine-guanine-phosphoribosyltransferase and 5′ nucleotidase. Biochemie 62 (1980) 665-670
11. Berger A., Schiltz E., and Schulz G.E. Guanylate kinase from Saccharomyces cerevisiae: Isolation and characterization, crystallization and preliminary X-ray analysis, amino acid sequence and comparison with adenylate kinases. Eur. J. Biochem. 184 2 (1989) 433-443
12. Bevilacqua G., Sobel M.E., Liotta L.A., and Steeg P.S. Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential. Cancer Res. 49 (1989) 5185-5190
13. Biggs J., Tripoulas N., Hersperger E., Dearolf C., and Shearn A. Analysis of the lethal interaction between the prune and Killer of prune mutations of Drosophila. Genes Dev. 2 (1988) 1333-1343
14. Biggs J., Hersperger E., Steeg P.S., Liotta L.A., and Shearn A. A Drosophila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase. Cell 63 5 (1990) 933-940
15. Brand A.M., and Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118 (1993) 401-415
16. Chiadmi M., Morera S., Lascu I., Dumas C., LeBras G., Veron M., and Janin J. The Awd nucleotide diphosphate kinase of Drosophila. Structure 1 (1993) 283-293
17. Chomey E., and Nash D. Guanine monophosphate synthetase and the burgundy locus in Drosophila melanogaster. In A. Conf. Dros. Res. Num. 37 (1996) 378
18. Clancey C.W. Drosophila Information Service 34 (1959) 48
19. Clark D.V. Molecular and genetic analyses of Drosophila Prat, which encodes the first enzyme of de novo purine biosynthesis. Genetics 136 (1994) 547-557
20. Curtius H.C., Heintel D., Ghisla S., Kuster T., Leimbacher W., and Niederwieser A. Tetrahydrobiopterin biosynthesis: Studies with specifically labeled (2H)NAD(P)H and 2H2O and of the enzymes involved. Eur. J. Biochem. 148 (1985) 413-419
21. Curtius H.C., Takikawa S., and Niederwieser A. Tetrahydrobiopterin biosynthesis in man. Chemistry and Biology of Pteridines (1986), Walter du Gruyter, Berlin 142-149
22. Davis M.D., and Kaufman S. 7-Tetrahydrobiopterin is an uncoupled cofactor for rat hepatic phenylalanine hydroxylase. FEBS Lett. 285 (1991) 17-20
23. Davis M.D., Kaufman S., and Milstien S. Conversion of 6-substituted tetrahydropterins to 7-isomers via phenylalanine hydroxylase-generated intermediates. Proc. Natl. Acad. Sci. USA 88 (1991) 385-389
24. Davis M.D., Ribeiro P., Tipper J., and Kaufman S. "7-Tetrahydrobiopterin," a naturally occurring analogue of tetrahydrobiopterin, is a cofactor for and a potential inhibitor of the aromatic amino acid hydroxylases. Proc. Natl. Acad. Sci. USA 89 (1992) 10109-10113
25. b3, a cell-autonomous lethal mutation of Drosophila induced by hybrid dysgenesis. Dev. Biol. 129 (1988) 159-168
26. b3, a cell-autonomous lethal mutation of Drosophila induced by hybrid dysgenesis. Dev. Biol. 129 (1988) 169-178
27. Dorsett D., Yim J.J., and Jacobson K.B. Biosynthesis of "drosopterins" by an enzyme system from Drosophila melanogaster. Biochemistry 18 (1979) 2596-2600
28. Dorsett D., and Jacobson K.B. Purification and biosynthesis of quench spot, a drosopterin precursor in Drosophila melanogaster. Biochemistry 21 6 (1982) 1238-1243
29. Dumas C., Lascu I., Morera S., Glaser P., Fourme R., Wallet V., Lacombe M.L., Veron M., and Janin J. X-ray structure of nucleoside diphosphate kinase. EMBO J. 11 (1992) 3203-3208
30. 32P] triphosphate. Eur. J. Biochem. 9 (1993) 451-455
31. Evans B.A., and Howells A.J. Control of drosopterin synthesis in Drosophila melanogaster: Mutants showing an altered pattern of GTP cyclohydrolase activity during development. Biochem. Genet. 16 (1978) 13-25
32. Fan C.L., and Brown G.M. Partial purification and some properties of biopterin synthase and dihydropterin oxidase from Drosophila melanogaster. Biochem. Genet 17 (1979) 351-369
33. Ferre J., Silva F.J., Real M.D., and Mensua J.L. Pigment patterns in mutants affecting the biosynthesis of pteridines and xanthommatin in Drosophila melanogaster. Biochem. Genet. 24 (1986) 545-569
34. Florenes V.A., Aamdal S., Myklebost O., Maelandsmo G.M., Bruland O.S., and Fodstad O. Levels of nm23 mRNA in metastatic malignant melanomas/Inverse correlation to disease progression. Cancer Res. 52 (1992) 6088-6091
35. Forrest H.S., Glassman E., and Mitchell H.K. Conversion of 2-amino 3,4 dihydro-4-oxopteridine to isoxanthopterin in Drosophila melanogaster. Science 124 (1956) 725-726
36. Frolov M.V., and Alatortsev V.E. Cluster of cytochrome P450 genes on the X chromosome of Drosophila melanogaster. DNA Cell Biol. 13 (1994) 663-668
37. Frolov M.V., Zverlov V.V., and Alatortzev V.E. The mRNA product of the Drosophila gene prune is spliced and encodes a protein containing a putative transmembrane domain. Mol. Gen. Genet. 242 (1994) 478-483
38. Gateff E., and Schneiderman H.A. Developmental capacities of benign and malignant neoplasms of Drosophila. Roux Arch. Dev. Biol. 176 (1974) 23-65
39. Gentry D., Bengra C., Ikehara K., and Cashel M. Guanylate kinase of Escherichia coli K-12. J. Biol. Chem. 268 19 (1993) 14316-14321
40. Ghandi R., Varak E., and Goldberg M.L. Molecular analysis of a cytochrome P450 gene of family-4 on the Drosophila X-chromosome. DNA Cell Biol. 11 (1992) 397-404
41. Gilles A.M., Presecan E., Vonica A., and Lascu I. Nucleoside diphosphate kinase from human erythrocytes: Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme. J. Biol. Chem. 266 (1991) 8784-8789
42. Glass H.B. New mutants report. Drosophila Information Service 2 (1934) 7-8
43. + on xanthine dehydrogenase of Drosophila melanogaster. II. Xanthine dehydrogenase activity during development. Proc. Natl. Acad. Sci. USA 48 (1962) 1712-1718
44. Grell E.H. The autonomy of reciprocal eye transplant between pn and Kpn. Drosophila Information Service 32 (1958) 123-124
45. Hackstein J.H.P. "Prune"/"Killer-of-Prune": A complementary lethal system in Drosophila melanogaster affecting pteridine metabolism. In: Pfleiderer W. (Ed). Chemistry and Biology of Pteridines (1975), Walter de Gruyter, Berlin 429-436
46. Hackstein J.H.P. The lethal prune/Killer of prune interaction of Drosophila causes a syndrome resembling human neurofibromatosis (NF1. Eur. J. Cell. Biol. 58 (1992) 429-444
47. Hadorn E., and Mitchell H.K. Properties of mutants of Drosophila melanogaster and changes during development as revealed by paper chromatography. Proc. Natl. Acad. Sci. USA 37 (1951) 650-665
48. Hankins, G. R. (1991). "Analysis of a Drosophila Neuroblastoma Gene." Ph.D. Thesis, University of Virginia, Charlottesville, VA
49. Hao H., Tyshenko M.G., and Walker V.K. Dihydrofolate reductase of Drosophila: Cloning and expression of a gene with a rare transcript. J. Biol. Chem. 269 (1994) 15179-15185
50. Harada T., Kagamiyama H., and Hatakeyama K. Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity. Science 260 (1993) 1507-1510
51. Hennesy C., Henry J.A., May F.E.B., Westly B.R., Angus B., and Lennard T.W.J. Expression of the anti-metastatic gene nm23 in human breast cancer; association with good prognosis. J. Natl. Cancer Inst. 83 (1991) 281-285
52. Hildebrandt M., Lacombe M.-L., Mesnildrey S., and Veron M. A human NDP-kinase B specifically binds single-stranded poly-pyrimidine sequences. Nucleic Acids Res. 23 19 (1995) 3858-3864
53. Hirayama R., Sawai S., Takagi Y., Mishima Y., Kimura N., Shimada N., Esaki Y., Kurashima C., Utsuyama M., and Hirokawa K. Positive relationship between expression of anti-metastatic factor (nm23 gene product or nucleoside diphosphate kinase) and good prognosis in human breast cancer. J. Natl. Cancer Inst. 83 (1991) 1249-1250
54. Hopkins F.G. Nature 40 (1889) 335
55. Ilyina O.V. Report of new mutants: Drosophila melanogaster. Drosophila Information Service 55 (1980) 205
56. Johnson D.H. Adenine phosphoribosyltransferase genes in two Drosophila species: Dosage compensation, a nuclear matrix attachment site, and a novel intron position. Mol. Gen. Genet. 238 (1993) 383-389
57. Johnson D.H., Edstrom J.E., Burnett J.B., and Friedman T.B. Cloning of a Drosophila melanogaster adenine phosphoribosyltransferase structural gene and deduced amino acid sequence of the enzyme. Gene 59 (1987) 77-86
58. Johnson M.M., Nash D., and Henderson J.F. Metabolism of guanine and guanosine in larvae of Drosophila melanogaster. Comp. Biochem. Physiol. 66 (1980) 563-567
59. Johnstone M.E., Nash D., and Naguib F.N. Three purine auxotrophic loci on the second chromosome of Drosophila melanogaster. Biochem. Genet 23 (1985) 7-8
60. Kamdar K.P., Shelton M.E., and Finnerty V. The Drosophila molybdenum cofactor gene cinnamon is homologous to three E. coli cofactor proteins and to the rat gephyrin. Genetics 137 (1994) 791-801
61. Karlsson A., Mesnildrey S., Xu Y., Morera S., Janin J., and Veron M. Nucleoside diphosphate kinase: Investigation of the intersubunit contacts by site directed mutagenesis and crystallography. J. Biol. Chem. (1996) in press
62. Katz D.A., and Liotta L.A. Tumor invasion and metastasis in the central nervous system. Prog. Neuropathol. 6 (1986) 119-131
63. Kaufman T.C. New mutants report. Drosophila Information Service 45 (1970) 34
64. Keim D., Hailat N., Melhem R., Zhu X.X., Lascu I., Veron M., Strahler J., and Hanash S.M. Proliferation-related expression of p19/nm23 nucleoside diphosphate kinase. J. Clin. Invest. 89 (1992) 919-924
65. Keith T.P., Riley M.A., Kreitman M.E., Lewontin R.C., Curtis D., and Chambers G. Sequence of the structural gene for xanthine dehydrogenase (rosy locus) in Drosophila melanogaster. Genetics 116 (1987) 67-73
66. Kim N., and Yim J. Cloning of Drosophila purple gene and expression in E. coli: purple gene encodes PTP synthase. Pteridines 6 3 (1995) 119-122
67. Kimura N., Shimada N., Nomura K., and Watanabe K. Isolation and characterization of a cDNA clone encoding rat nucleoside diphosphate kinase. J. Biol. Chem. 265 (1990) 15744-15749
68. King R.C. New mutants report. Drosophila Information Service 26 (1951) 65
69. Konrad M. Cloning and expression of the essential gene for guanylate kinase from yeast. J. Biol. Chem. 267 36 (1992) 25652-25655
70. Krivi G.G., and Brown G.M. Purification and properties of the enzymes from Drosophila melanogaster that catalyze the synthesis of sepiapterin from dihydroneopterin triphosphate. Biochem. Genet. 17 (1979) 371-390
71. Lacombe M.L., Wallet V., Troll H., and Veron M. Functional cloning of a nucleoside diphosphate kinase from Dictyostelium discoideum. J. Biol. Chem. 265 (1990) 10012-10018
72. Lascu I., Chaffotte A., Limbourg-Bouchon B., and Veron M. A Pro/Ser substitution in nucleoside diphosphate kinase of Drosophila melanogaster (mutation Killer of prune) affects stability but not catalytic efficiency of the enzyme. J. Biol. Chem. 267 (1992) 12775-12781
73. Leone A., Flatow U., King C.R., Sandeen M.A., Margulies I.M., Liotta L.A., and Steeg P.S. Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell 65 (1991) 25-35
74. Leone A., Flatow U., VanHoutte K., and Steeg P.S. Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: Effects on tumor metastatic potential, colonization and enzymatic activity. Oncogene 8 (1993) 2325-2333
75. Leone A., Seeger R.C., Arboleda J., Slamon D.J., and Steeg P.S. NM23 in childhood neuroblastoma. Oncogene 8 (1992) 855-865
76. Lewis E. Remembering Sturtevant. Genetics 141 (1995) 1227-1230
77. Lifschytz E., and Falk R. A new system for fine structure analysis of genes in Drosophila. Drosophila Information Service 43 (1968) 131
78. Lifschytz E., and Falk R. The action of the gene prune (pn) in Drosophila melanogaster. Genet. Res. Camb. 14 (1969) 53-61
79. Lifschytz E., and Falk R. A genetic analysis of the Killer-prune (K-pn) locus of Drosophila melanogaster. Genetics 62 (1969) 353-358
80. Lubeck J., and Soll J. Nucleoside diphosphate kinase from pea chloroplasts: Purification, cDNA cloning and import into chloroplasts. Planta 196 (1995) 668-673
81. MacDonald N.J., Freije J.M.P., Stracke M.L., Manrow R.E., and Steeg P.S. Site directed mutagenesis of nm23-H1: Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells. J. Biol. Chem. (1996) in press
82. Mackay W.J., and Donnell O.'J.M. A genetic analysis of the pteridine biosynthetic enzyme, guanosine triphosphate cyclohydrolase, in Drosophila melanogaster. Genetics 105 (1983) 35-53
83. Mayer B., John M., Heinzel B., Werner E.R., Wachter H., Schultz G., and Bohme E. Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase. FEBS Lett. 288 (1991) 187-191
84. Mittler S. New mutants report. Drosophila Information Service 42 (1967) 38
85. Moiseenko E.V., and Kakpakov V.T. The absence of hypoxanthine-guanine phosphoribosyl-transferase in extracts of Drosophila melanogaster and established embryonic diploid cell lines. Dros. Info. Serv. 51 (1974) 44-45
86. Morales G., Requena J.M., Jimenez-Ruiz A., Lopez M.C., Ugarte M., and Alonso C. Sequence and expression of the Drosophilai phenylalanine hydroxylase mRNA. Gene 93 (1990) 213-219
87. Morera S., Lascu I., Dumas C., LeBras G., Briozzo P., Veron M., and Janin J. Adenosine 5′-diphosphate binding and the active site of nucleoside diphosphate kinase. Biochemistry 33 (1994) 459-467
88. Morera S., LeBras G., Lascu I., Lacombe M.L., Veron M., and Janin J. Refined X-ray structure of Dictyostelium discoideum nucleoside diphosphate kinase at 1.8 A resolution. J. Mol. Biol. 243 5 (1994) 873-890
89. Mariguchi M., Kohno H., Kamei M., and Tochikura T. Purification and properties of guanylate kinase from baker's yeast. Biochim. Biophys. Acta 662 1 (1981) 165-167
90. Nar H., Huber R., Heizmann C.W., Thony B., and Burgisser D. Three-dimensional structure of 6-pyruvoyl tetrahydropterin synthase, an enzyme involved in tetrahydrobiopterin biosynthesis. EMBO J. 13 6 (1994) 1255-1262
91. Narayanan Y., and Weir J.A. Paper chromatography of pteridines of prune and clot stocks of Drosophila melanogaster. Genetics 50 (1964) 387-392
92. Nash D., Hu S., Leonard N.J., Tiong S.Y., and Fillips D. The raspberry locus of Drosophila melanogaster includes an inosine monophosphate dehydrogenase like coding sequence. Genome 37 (1994) 333-344
93. Nebert D.W., and Gonzalez F.J. P450 genes: Structure, evolution, and regulation. In: Richardson C.C., Boyer P.D., Bawid I.B., and Meister A. (Eds). Annual Review of Biochemistry (1987), Annual Reviews Inc., Palo Alto, CA 945-993
94. Neckameyer W.S., and White K. A single locus encodes both phenylalanine hydroxylase and tryptophan hydroxylase activities in Drosophila. J. Biol. Chem. 267 (1992) 4199-4206
95. Nelson D.R., Kamataki T., Waxman D.J., Guengerich F.P., Estabrook R.W., Feyereisen F.J., Gonzalez F.J., Coon M.J., Gunsalus I.C., and Gotoh O. The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 12 (1993) 1-51
96. Nickerson J.A., and Wells W.W. The microtubule-associated nucleoside diphosphate kinase. J. Biol. Chem. 18 (1984) 11297-11304
97. Nomura T., Yatsunami K., Honda A., Sugimoto Y., Fukui T., Zhang J., Yamamoto J., and Ichikawa A. The amino acid sequence of nucleoside diphosphate kinase I from spinach leaves, as deduced from the cDNA sequence. Arch. Biochem. Biophys. 297 (1992) 42-45
98. O'Donnell J.M., McLean J.R., and Reynolds E.R. Molecular and developmental genetics of the Punch locus, a pterin biosynthesis gene in Drosophila melanogaster. Dev. Genet 10 (1989) 273-286
99. Orevi N., and Falk R. Temperature-sensitive prune (pn) mutations of Drosophila melanogaster. Mutat. Res 33 (1975) 193-200
100. Ouatas T., and Mazabraud A. Nucleoside diphosphate kinase from Xenopus laevis. First International Workshop on nm23/NDP kinase (1995), Institut Pasteur
101. Park Y.S., Kim J.H., Jacobson K.B., and Yim J.J. Purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from Drosophila melanogaster. Biochim. Biophys. Acta 1038 (1990) 186-194
102. Parks R., and Agarwal R. Nucleoside diphosphokinase. In: Boyer P.D. (Ed). The Enzymes (1973), Academic Press, New York 307-344
103. Phillips J.S., and Forrest H.S. Ommochromes and pteridines. In: Ashburner M., and Wright T.R.F. (Eds). The Genetics and Biology of Drosophila (1980), Academic Press, London 541-623
104. Postel E.H., Berberich S.J., Flint S.J., and Ferrone C.A. Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. Science 261 (1993) 478-480
105. Primus J.P., and Brown G.M. Sepiapterin reductase and the biosynthesis of tetrahydro-biopterin in Drosophila melanogaster. Insect Biochem. Mol. Biol 24 (1994) 907-918
106. Prota G. Melanins and Melanogenesis (1992), Academic Press, San Diego
107. Rajagopalan K.V., and Johnson J.L. The pterin molybdenum cofactors. J. Biol. Chem. 267 15 (1992) 10199-10202
108. Rancourt S.L., and Walker V.K. The purification of dihydrofolate reductase from Drosophila melanogaster. Biochim. Biophys. Acta 1039 (1990) 261-268
109. Reaume A.G., Clark S.H., and Chovnik A. Xanthine dehydrogenase is transported to the Drosophila eye. Genetics 123 (1989) 503-509
110. Regulski M., and Tully T. Molecular and biochemical characterization of dNOS: A Drosophila Ca[2+] calmodulin-dependent nitric oxide synthase. Proc. Natl. Acad. Sci. USA 92 (1995) 9072-9076
111. Rembold H., and Gutensohn W. 6-Hydroxylation of the pteridine ring by xanthine oxidase. Biochem. Biophys. Res. Commun. 31 (1968) 837-841
112. Rosengard A.M., Krutzsch H.C., Shearn A., Biggs J.R., Barker E., Margulies I.M., King C.R., Liotta L.A., and Steeg P.S. Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development. Nature 6246 (1989) 177-180
113. Rossmann M.G., Liljas A., Branden C.I., and Banaszak L.J. Enzymes 11 (1975) 61-102
114. Sastre-Garau X., Lacombe M.L., Jouve M., Veron M., and Magdelenat H. Nucleoside diphosphate kinase/NM23 expression in breast cancer: Lack of correlation with lymph-node metastasis. Int. J. Cancer 50 (1992) 533-538
115. Schallreuter K.U., Wood J.M., Pittelkow M.R., Gutlich M., Lemke K.R., Rodl W., Swanson N.N., Hitzemann K., and Ziegler I. Regulation of melanin biosynthesis in the human epidermis by tetrahydrobiopterin. Science 263 (1994) 1444-1446
116. Schoedon G., Redweik U., Frank G., Cotton R.G., and Blau N. Allosteric characteristics of GTP cyclohydrolase I from Escherichia coli. Eur. J. Biochem 210 (1992) 561-568
117. Schott D.R., Baldwin M.C., and Finnerty V. Molybdenum hydroxylases in Drosophila III. Further characterization of the low xanthine dehydroxylase gene. Biochem. Genet. 24 (1986) 509-527
118. Schwinck I. Aurodrosopterins in eye colour mutants of Drosophila melanogaster. In: Pfleiderer W. (Ed). Chemistry and Biology of Pteridines (1975), Walter de Gruyter, Berlin 919-930
119. Shen R.S., Alam A., and Zhang Y.X. Inhibition of GTP cyclohydrolase I by pterins. Biochim. Biophys. Acta 965 (1988) 9-15
120. Shimada N., Ishikawa N., Munakata Y., Toda T., Watanabe K., and Kimura N. A second form (beta isoform) of nucleoside diphosphate kinase from rat: Isolation and characterization of complementary genomic DNA and expression. J. Biol. Chem. 268 (1993) 2583-2589
121. Shinoda T., and Glassman E. Multiple molecular forms of xanthine dehydrogenase and related enzymes. II. Conversion of one form of xanthine dehydrogenase to another by extracts of Drosophila melanogaster. Biochim. Biophys. Acta 160 (1968) 178-187
122. Sifri C.D., Wilson K., Smolik S., Forte M., and Ullman B. Cloning and sequence analysis of a Drosophila melanogaster IMP dehydrogenase. Biochim. Biophys. Acta 1217 (1994) 103-106
123. Silva F.J., Escriche B., Ordono E., and Ferre J. Genetic and biochemical characterization of little isoxanthopterin (lix), a gene controlling dihydropterin oxidase activity in Drosophila melanogaster. Mol. Gen. Genet 230 (1991) 97-103
124. Slee R., and Bownes M. The raspberry locus encodes Drosophila inosine monophosphate dehydrogenase. Mol. Gen. Genet. 248 (1995) 755-766
125. Slobodyanyuk S.Y., and Serov O.L. Variations in the expression of the gene Pgd due to the effect of chromosomal rearrangements in Drosophila. Mol. Gen. Genet 191 (1983) 372-377
126. Smith G.K. On the role of sepiapterin reductase in the biosynthesis of tetrahydrobiopterin. Arch. Biochem. Biophys. 255 (1987) 254-266
127. Sobels F.H. New mutants report. Drosophila Information Service 32 (1958) 84-86
128. Spradling A.C., and Rubin G.M. Transposition of cloned P elements into Drosophila germ line chromosomes. Science 218 (1982) 341-347
129. Stahl J.A., Leone A., Rosengard A.M., Porter L., King C.R., and Steeg P.S. Identification of a second human nm23 gene, nm23-H2. Cancer Res 51 (1991) 445-449
130. Steeg P.S., Bevilacqua G., Kopper L., Thorgeirsson U.P., Talmadge J.E., Liotta L.A., and Sobel M.E. Evidence for a novel gene associated with low tumor metastatic potential. J. Natl. Cancer Inst. 80 (1988) 200-204
131. Steeg P.S., Bevilacqua G., Pozzatti R., Liotta L.A., and Sobel M.E. Altered expression of NM23, a gene associated with low tumor metastatic potential, during adenovirus 2 Ela inhibition of experimental metastasis. Cancer Res. 48 (1988) 6550-6554
132. Stehle T., and Schulz G.E. Refined structure of the complex between guanylate kinase and its substrate GMP at 2.0 A resolution. J. Mol. Biol. 224 4 (1992) 1127-1141
133. Stilvaletta L.A., Warner C.K., Langley S., and Finnerty V. Molybdoenzymes in Drosophila. IV. Further characterization of the cinnamon phenotype. Mol. Gen. Genet. 213 (1988) 505-512
134. Strand D., Raska I., and Mechler B.M. The Drosophila lethal(2) giant larvae tumor suppressor protein is a component of the cytoskeleton. J. Cell Biol. 27 4 (1994) 1345-1360
135. Sturtevant A.H. A highly specific complementary lethal system in Drosophila melanogaster. Genetics 41 (1956) 118-123
136. Switchenko A.C., Primus J.P., and Brown G.M. Intermediates in the enzymic synthesis of tetrahydrobiopterin in Drosophila melanogaster. Biochem. Biophys. Res. Commun 120 (1984) 754-760
137. Switchenko A.C., and Brown G.M. The enzymatic conversion of dihydroneopterin triphosphate to tripolyphosphate and 6-pyruvoyl-tetrahydropterin, an intermediate in the biosynthesis of other pterins in Drosophila melanogaster. J. Biol. Chem 260 (1985) 2945-2951
138. Teng D.H., Bender L.B., Engele C.M., Tsubota S.I., and Venkatesh T.R. Isolation and characterization of the prune locus of Drosophila melanogaster. Genetics 128 (1991) 373-380
139. Timmons L., Hersperger E., Woodhouse E., Xu J., Liu L.-Z., and Shearn A. The expression of the Drosophila awd gene during normal development and in neoplastic brain tumors caused by Igl mutations. Dev. Biol 158 (1993) 364-379
140. Kpm which revert the prune/Killer of prune lethal interaction affect conserved residues that are involved in nucleoside diphosphate kinase substrate binding and catalysis. J. Biol. Chem. 270 (1995) 23021-23030
141. L. Timmons, A. Shearn (1996). Germline transformation using a prune cDNA rescues prune/Killer of prune letrality and the prune eye color phenotype. Genetics (in press)
142. Tiong S.Y.K., Keizer C., Nash D., and Patterson D. Drosophila purine auxotrophy: New alleles of adenosine 2 exhibiting a complex visible phenotype. Biochem. Genet. 27 (1989) 333-348
143. Tiong S.Y.K., and Nash D. Genetic analysis of the adenosine3 (Gart) region of the second chromosome of Drosophila melanogaster. Genetics 124 (1990) 889-897
144. Troll H., Winckler T., Lascu I., Muller N., Saurin W., Veron M., and Mutzel R. Separate nuclear genes encode cytosolic and mitochondrial nucleoside diphosphate kinase in Dictyostelium discoideum. J. Biol. Chem 268 (1993) 25469-25475
145. Unnash T.R., and Brown G.M. Purification and properties of dihydropterin oxidase from Drosophila melanogaster. J. Biol. Chem 257 (1982) 14211-14216
146. Urano T., Takamiya K., Furukawa K., and Shiku H. Molecular cloning and functional expression of the second mouse nm23/NDP kinase gene, nm23-M2. FEBS Lett 309 (1992) 358-362
147. Venturelli D., Martinez R., Melotti P., Casella I., Peschle C., Cucco C., Spampinato G., Darzynkiewicz Z., and Calabretta B. Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells. Proc. Natl. Acad. Sc. USA 92 16 (1995) 7435-7439
148. Wagenberg B.D., and Burdick B.A. Effect of K-pn on the pseudoalleles of the prune locus. Drosophila Information Service 44 (1969) 107
149. Wahl R.C., Warner C.K., Finnerty V., and Rajagopalan K.V. Drosophila malanogaster ma-I mutants are defective in the sulfuration of desulfo Mo hydroxylases. J. Biol. Chem. 257 (1982) 3958-3962
150. Webb P.A., Perisic O., Mendola C.E., Backer J.M., and Williams R.L. The crystal structure of a human nucleoside diphosphate kinase, NM23-H2. J. Mol. Biol. 251 (1995) 574-587
151. Webber S., and Whiteley J.M. Comparative activity of rat liver dihydrofolate reductase with 7,8-dihydrofolate and other 7,8-dihydropteridines. Arch. Biochem. Biophys. 236 (1985) 681-690
152. Weisberg E.P., and Donnell O.'J.M. Purification and characterization of GTP cyclohydrolase I from Drosophila melanogaster. J. Biol. Chem 261 3 (1986) 1453-1458
153. Wiederrecht G.J., and Brown G.M. Purification and properties of the enzymes from Drosophila melanogaster that catalyze the conversion of dihydroneopterin triphosphate to the pyrim-idodiazepine precursor of drosopterins. J. Biol. Chem. 259 (1984) 14121-14127
154. Wiederrecht G.J., Paton D.R., and Brown G.M. The isolation and identification of an intermediate involved in the biosynthesis of drosopterin in Drosophila melanogaster. J. Biol. Chem 256 (1981) 10399-10402
155. Wiederrecht G.J., Paton D.R., and Brown G.M. Enzymatic conversion of dihydroneopterin triphosphate to the pyrimidodiazepine intermediate involved in the biosynthesis of the drosopterins in Drosophila melanogaster. J. Biol. Chem 259 (1984) 2195-2200
156. Williams E.A., and Morrison J.F. Human dihydrofolate reductase: Reduction of alternative substrates, pH effects, and inhibition by deazafolates. Biochemistry 31 (1992) 6801-6811
157. Williams R.L., Oren D.A., Munoz-Dorado J., Inouye S., Inouye M., and Arnold E. Crystal structure of Myxococcus xanthus nucleoside diphosphate kinase and its interaction with a nucleotide substrate at 2.0 A resolution. J. Mol. Biol. 234 (1993) 1230-1247
158. Wilson T.G., and Jacobson K.B. Mechanism of suppression in Drosophila. V. Localization of the purple mutant of Drosophila melanogaster in the pteridine biosynthetic pathway. Biochem. Genet. 15 (1977) 321-332
159. Woodhouse E., Hersperger E., and Shearn A. Growth, metastasis, and invasiveness of Drosophila tumors (1996) Submitted for publication
160. Woods D., and Bryant P. The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell 66 3 (1991) 451-464
161. Xu J., Liu L.-Z., Deng X., Timmons L., Hersperger E., Steeg P.S., Veron M., and Shearn A. The enzymatic activity of Drosophila AWD/NDP kinase is necessary but not sufficient for its biological function. Dev. Biol. 177 (1996) 544-557
162. Yen T.T., and Glassman E. Electrophoretic variants of xanthine dehydrogenase in Drosophila melanogaster. Genetics 54 (1966) 369-370
163. Yim J.J., Crummett D.D., and Jacobson K.B. A new enzyme in pteridine metabolism that cleaves the side chain of dihydroneopterin triphosphate. Fed. Proc. 6 (1978) 1344
164. Yim J.J., Jacobson K.B., and Crummett D. Detection and some properties of an enzyme from Drosophila melanogaster that releases the side chain from dihydroneopterin triphosphate. Insect Biochem. 11 (1981) 363-370
165. Zhang J., Nomura T., Yatsunami K., Honda A., Sugimoto Y., Moriwaki T., Yamamoto J., Ohta M., Fukui T., and Ichikawa A. Nucleotide sequence of the cDNA encoding nucleoside diphosphate kinase II from spinach leaves. Biochim. Biophys. Acta 1171 (1993) 304-306
166. Ziegler I., and Harmsen R. The biology of pteridines in insects. Adv. Insect Physiol. 6 (1969) 139-203