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Volumn 3, Issue 1, 1997, Pages 11-20

Surface Antigens of the Syphilis Spirochete and Their Potential as Virulence Determinants

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; MEMBRANE ANTIGEN; MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN; PORIN; RECOMBINANT PROTEIN; TROMP1 PROTEIN, TREPONEMA PALLIDUM; TROMP2 PROTEIN, TREPONEMA PALLIDUM;

EID: 0030623998     PISSN: 10806040     EISSN: None     Source Type: Journal    
DOI: 10.3201/eid0301.970102     Document Type: Article
Times cited : (31)

References (47)
  • 1
    • 0009817530 scopus 로고
    • Cases of selected notifiable diseases
    • Centers for Disease Control and Prevention. Cases of selected notifiable diseases. MMWR Morb Mortal Wkly Rep 1995;44:917.
    • (1995) MMWR Morb Mortal Wkly Rep , vol.44 , pp. 917
  • 2
    • 0024308491 scopus 로고
    • Demonstration of rare protein in the outer membrane of Treponema pallidum subp. pallidum by freeze-fracture analysis
    • Walker EM, Zamphigi GA, Blanco DR, Miller JN, Lovett MA. Demonstration of rare protein in the outer membrane of Treponema pallidum subp. pallidum by freeze-fracture analysis. J Bacteriol 1989;171:5005-11.
    • (1989) J Bacteriol , vol.171 , pp. 5005-5011
    • Walker, E.M.1    Zamphigi, G.A.2    Blanco, D.R.3    Miller, J.N.4    Lovett, M.A.5
  • 3
    • 2642680890 scopus 로고
    • Outer membrane ultrastructure explains the limited antigenicity of virulent Treponema pallidum
    • Radolf JD, Norgard MV, Shulz WW. Outer membrane ultrastructure explains the limited antigenicity of virulent Treponema pallidum. Proc Natl Acad Sci USA 1989;86:2051-5.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 2051-2055
    • Radolf, J.D.1    Norgard, M.V.2    Shulz, W.W.3
  • 4
    • 0022455720 scopus 로고
    • Factors affecting the multiplication and subculture of Treponema pallidum subsp. pallidum in a tissue culture system
    • Norris SJ, Edmondson DG. Factors affecting the multiplication and subculture of Treponema pallidum subsp. pallidum in a tissue culture system. Infect Immun 1987;53:534-9.
    • (1987) Infect Immun , vol.53 , pp. 534-539
    • Norris, S.J.1    Edmondson, D.G.2
  • 5
    • 0018717694 scopus 로고
    • Surface-associated host proteins on virulent Treponema pallidum
    • Alderete JF, Baseman JB. Surface-associated host proteins on virulent Treponema pallidum. Infect Immun 1979;26:1048-56.
    • (1979) Infect Immun , vol.26 , pp. 1048-1056
    • Alderete, J.F.1    Baseman, J.B.2
  • 6
    • 0023370641 scopus 로고
    • Role of fibronectin in the pathgenesis of syphilis
    • Baughn RE. Role of fibronectin in the pathgenesis of syphilis. Reviews of Infectious Diseases 1987;9:372-85.
    • (1987) Reviews of Infectious Diseases , vol.9 , pp. 372-385
    • Baughn, R.E.1
  • 7
    • 0018775841 scopus 로고
    • Surface mucopolysaccharides of Treponema pallidum
    • Fitzgerald TJ, Johnson RC. Surface mucopolysaccharides of Treponema pallidum. Infect Immun 1979;24:244-51.
    • (1979) Infect Immun , vol.24 , pp. 244-251
    • Fitzgerald, T.J.1    Johnson, R.C.2
  • 8
    • 0006248945 scopus 로고
    • Adhesin-receptor recognition between the syphilis spirochete and fibronectin
    • Leive L, editor. Washington, (DC): American Society for Microbiology, 1986.
    • Baseman JB, Alderete JF, Freeman-Shade L, Thomas DD, Peterson KM. Adhesin-receptor recognition between the syphilis spirochete and fibronectin. In: Leive L, editor. Microbiology 1986. Washington, (DC): American Society for Microbiology, 1986.
    • (1986) Microbiology
    • Baseman, J.B.1    Alderete, J.F.2    Freeman-Shade, L.3    Thomas, D.D.4    Peterson, K.M.5
  • 10
    • 0022652804 scopus 로고
    • The surface of virulent Treponema pallidum: Resistance to antibody binding in the absence of complement and surface association of recombinant antigen 4D
    • Radolf JD, FehnigerTE, Siverblatt F, Miller JN, Lovett MA. The surface of virulent Treponema pallidum: resistance to antibody binding in the absence of complement and surface association of recombinant antigen 4D. Infect Immun 1986;52:579-85.
    • (1986) Infect Immun , vol.52 , pp. 579-585
    • Radolf, J.D.1    Fehniger, T.E.2    Siverblatt, F.3    Miller, J.N.4    Lovett, M.A.5
  • 11
    • 0018717663 scopus 로고
    • Electron microscopy of treponemes subjected to the Treponema pallidum immobilization (TPI) test
    • Hovind-Hougen K, Birch-Andersen A, Nielsen HA. Electron microscopy of treponemes subjected to the Treponema pallidum immobilization (TPI) test. APMS 1979;87:263-8.
    • (1979) APMS , vol.87 , pp. 263-268
    • Hovind-Hougen, K.1    Birch-Andersen, A.2    Nielsen, H.A.3
  • 12
    • 0022353755 scopus 로고
    • The outer membrane of Treponema pallidum: Biological significance and biochemical properties
    • Penn CW, Cockayne A, Bailey MJ. The outer membrane of Treponema pallidum: biological significance and biochemical properties. Journal of General Microbiology 1985;131:2349-57.
    • (1985) Journal of General Microbiology , vol.131 , pp. 2349-2357
    • Penn, C.W.1    Cockayne, A.2    Bailey, M.J.3
  • 13
    • 0021752971 scopus 로고
    • Antigenic complexity of Treponema pallidum: Antigenicity and surface localization of major plypeptides
    • Norris SJ, Sell S. Antigenic complexity of Treponema pallidum: antigenicity and surface localization of major plypeptides. J Immunol 1984;133:2686-92.
    • (1984) J Immunol , vol.133 , pp. 2686-2692
    • Norris, S.J.1    Sell, S.2
  • 14
    • 0023198299 scopus 로고
    • Changes in the cell surface properties of Treponema pallidum that occur during in vitro incubation of freshly extracted organisms
    • Stamm SV, Hokinka RL, Wyrick PB, Bassford PJ. Changes in the cell surface properties of Treponema pallidum that occur during in vitro incubation of freshly extracted organisms. Infect Immunol 1987;55:2255-61.
    • (1987) Infect Immunol , vol.55 , pp. 2255-2261
    • Stamm, S.V.1    Hokinka, R.L.2    Wyrick, P.B.3    Bassford, P.J.4
  • 15
    • 0024204047 scopus 로고
    • Selective release of the Treponema pallidum outer membrane and associated polypeptides with triton X-114
    • Cunningham TM, Walker EM, Miller JN, Lovett MA. Selective release of the Treponema pallidum outer membrane and associated polypeptides with triton X-114. J Bacteriol 1988;170:5789-96.
    • (1988) J Bacteriol , vol.170 , pp. 5789-5796
    • Cunningham, T.M.1    Walker, E.M.2    Miller, J.N.3    Lovett, M.A.4
  • 16
    • 0023840684 scopus 로고
    • Identification and localization of integral membrane proteins of virulent Treponema pallidum by phase partitioning with the nonionic detergent triton X-114
    • Radolf JD, Chamberlain NR, Clausell A, Norgard MV. Identification and localization of integral membrane proteins of virulent Treponema pallidum by phase partitioning with the nonionic detergent triton X-114. Infect Immun 1988;56:490-8.
    • (1988) Infect Immun , vol.56 , pp. 490-498
    • Radolf, J.D.1    Chamberlain, N.R.2    Clausell, A.3    Norgard, M.V.4
  • 18
    • 0024421344 scopus 로고
    • Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi
    • Bergstrom S, Bundoc VG, Barbour AG. Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi. Mol Microbiol 1989;3:479-86.
    • (1989) Mol Microbiol , vol.3 , pp. 479-486
    • Bergstrom, S.1    Bundoc, V.G.2    Barbour, A.G.3
  • 19
    • 0030013042 scopus 로고    scopus 로고
    • Molecular cloning and sequence analysis of the gene encoding LipL41, a surface-exposed lipoprotein of pathogenic Leptospira species
    • Shang ES, Summers TA, Haake DA. Molecular cloning and sequence analysis of the gene encoding LipL41, a surface-exposed lipoprotein of pathogenic Leptospira species. Infect Immun 1996;64:2322-30.
    • (1996) Infect Immun , vol.64 , pp. 2322-2330
    • Shang, E.S.1    Summers, T.A.2    Haake, D.A.3
  • 20
    • 0025360031 scopus 로고
    • Complement activation limits the rate of in vitro treponemicidal activity and correlates with antibody-mediated aggregation of Treponema pallidum rare outer membrane protein
    • Blanco DR, Walker EM, Haake DA, Champion CI, Miller JN, Lovett MA. Complement activation limits the rate of in vitro treponemicidal activity and correlates with antibody-mediated aggregation of Treponema pallidum rare outer membrane protein. J Immunol 1990;144:1914-21.
    • (1990) J Immunol , vol.144 , pp. 1914-1921
    • Blanco, D.R.1    Walker, E.M.2    Haake, D.A.3    Champion, C.I.4    Miller, J.N.5    Lovett, M.A.6
  • 21
    • 0029054274 scopus 로고
    • Membrane topology of Borrelia burgdorferi and Treponema pallidum lipoproteins
    • Jones JD, Bourell KW, Norgard MV, Radolf JD. Membrane topology of Borrelia burgdorferi and Treponema pallidum lipoproteins. Infect Immun 1995;63:2424-34.
    • (1995) Infect Immun , vol.63 , pp. 2424-2434
    • Jones, J.D.1    Bourell, K.W.2    Norgard, M.V.3    Radolf, J.D.4
  • 22
    • 0015621448 scopus 로고
    • Immunity in experimental syphilis. VI. Successful vaccination of rabbits with Treponema pallidum, Nichols strain, attenuated by gamma-irradiation
    • Miller JN. Immunity in experimental syphilis. VI. Successful vaccination of rabbits with Treponema pallidum, Nichols strain, attenuated by gamma-irradiation. J Immunol 1973;110:1206-15.
    • (1973) J Immunol , vol.110 , pp. 1206-1215
    • Miller, J.N.1
  • 24
    • 0028297815 scopus 로고
    • Fatty acids of Borrelia burgdorferi and Treponema pallidum lipoproteins
    • Belisle JT, Akins DR, Radolf JD, Norgard MV. Fatty acids of Borrelia burgdorferi and Treponema pallidum lipoproteins. J Bacteriol 1994;176:2151-7.
    • (1994) J Bacteriol , vol.176 , pp. 2151-2157
    • Belisle, J.T.1    Akins, D.R.2    Radolf, J.D.3    Norgard, M.V.4
  • 25
    • 0029091151 scopus 로고
    • Treponema pallidum and the quest for outer membrane proteins
    • Radolf JD. Treponema pallidum and the quest for outer membrane proteins. Mol Microbiol 1995;16:1067-73.
    • (1995) Mol Microbiol , vol.16 , pp. 1067-1073
    • Radolf, J.D.1
  • 26
    • 0027537675 scopus 로고
    • Lipid modification of the 17-kilodalton membrane immunogen of Treponema pallidum determines macrophage activation as well as amphilicity
    • Akins DR, Purcell BK, Mitra MM, Norgard MV, Radolf JD. Lipid modification of the 17-kilodalton membrane immunogen of Treponema pallidum determines macrophage activation as well as amphilicity. Infect Immun 1993;61:1201-10.
    • (1993) Infect Immun , vol.61 , pp. 1201-1210
    • Akins, D.R.1    Purcell, B.K.2    Mitra, M.M.3    Norgard, M.V.4    Radolf, J.D.5
  • 27
    • 0024787591 scopus 로고
    • Characterization of lipid-modified immunogenic proteins of Treponema pallidum expressed in Escherichia coli
    • Schouls LM, Mout R, Dekker J, van Embden JDA. Characterization of lipid-modified immunogenic proteins of Treponema pallidum expressed in Escherichia coli. Microb Pathog 1989;7:175-88.
    • (1989) Microb Pathog , vol.7 , pp. 175-188
    • Schouls, L.M.1    Mout, R.2    Dekker, J.3    Van Embden, J.D.A.4
  • 29
    • 0007959745 scopus 로고
    • Model membrane studies of porin function
    • Inouye M, editor. New York: John Wiley and Sons
    • Hancock REW. Model membrane studies of porin function. In: Inouye M, editor. Bacterial outer membranes as model systems. New York: John Wiley and Sons, 1986.
    • (1986) Bacterial Outer Membranes as Model Systems
    • Hancock, R.E.W.1
  • 31
    • 0028206457 scopus 로고
    • Characterization of the porin of Rhodobacter capsulatus 3764 in planar lipid bilayers
    • Bishop ND, Leu EJ. Characterization of the porin of Rhodobacter capsulatus 3764 in planar lipid bilayers. FEBS Lett 1994;349:69-74.
    • (1994) FEBS Lett , vol.349 , pp. 69-74
    • Bishop, N.D.1    Leu, E.J.2
  • 32
    • 0025156089 scopus 로고
    • Complement component C3 fixes selectively to the major outer membrane protein (MOMP) of Legionella pneumophila and mediates phagocytosis of liposome-MOMP complexes by human monocytes
    • Bellinger-Kawahara C, Horwitz MA. Complement component C3 fixes selectively to the major outer membrane protein (MOMP) of Legionella pneumophila and mediates phagocytosis of liposome-MOMP complexes by human monocytes. J Exp Med 1990;172:1201-10.
    • (1990) J Exp Med , vol.172 , pp. 1201-1210
    • Bellinger-Kawahara, C.1    Horwitz, M.A.2
  • 33
    • 0025233761 scopus 로고
    • Chlamydia trachomatis-host cell interactions: Role of the chlamydial major outer membrane protein as an adhesin
    • Su H, Watkins NG, Zhang YX, Caldwell HD. Chlamydia trachomatis-host cell interactions: role of the chlamydial major outer membrane protein as an adhesin. Infect Immun 1990;58:1017-25.
    • (1990) Infect Immun , vol.58 , pp. 1017-1025
    • Su, H.1    Watkins, N.G.2    Zhang, Y.X.3    Caldwell, H.D.4
  • 34
    • 0027943264 scopus 로고
    • Immunization with a multiple antigen peptide containing defined B- and T-cell epitopes: Production of bactericidal antibodies against group B Neisseria meningitidis
    • Christodoulides M, Heckels JE. Immunization with a multiple antigen peptide containing defined B- and T-cell epitopes: production of bactericidal antibodies against group B Neisseria meningitidis. Microbiol 1994;140:2951-60.
    • (1994) Microbiol , vol.140 , pp. 2951-2960
    • Christodoulides, M.1    Heckels, J.E.2
  • 35
    • 0346329038 scopus 로고
    • Outer membrane proteins of Neisseria gonorrhoeae
    • Ayoub EM, Cassell GH, Branche WC, Henry TJ, editors. Washington (DC): American Society for Microbiology
    • Elkins C, Sparling PF. Outer membrane proteins of Neisseria gonorrhoeae. In: Ayoub EM, Cassell GH, Branche WC, Henry TJ, editors. Microbial determinants of virulence and host response. Washington (DC): American Society for Microbiology, 1990.
    • (1990) Microbial Determinants of Virulence and Host Response
    • Elkins, C.1    Sparling, P.F.2
  • 36
    • 0023695038 scopus 로고
    • Human bactericidal antibody response to outer membrane protein P2 of nontypeable Haemophilus influenzae
    • Murphy TF, Bartos LC. Human bactericidal antibody response to outer membrane protein P2 of nontypeable Haemophilus influenzae. Infect Immun 1988;56:2673-9.
    • (1988) Infect Immun , vol.56 , pp. 2673-2679
    • Murphy, T.F.1    Bartos, L.C.2
  • 37
    • 0023552097 scopus 로고
    • Protective efficacy of monoclonal antibodies to class 1 and class 3 outer membrane proteins of Neisseria meningitidis B:15:P1.16 in infant rat infection model: New prospects for vaccine development
    • Saukkonen K, Abdillahi H, Poolman JT, Leinonen M. Protective efficacy of monoclonal antibodies to class 1 and class 3 outer membrane proteins of Neisseria meningitidis B:15:P1.16 in infant rat infection model: new prospects for vaccine development. Microb Pathog 1987;3:261-7.
    • (1987) Microb Pathog , vol.3 , pp. 261-267
    • Saukkonen, K.1    Abdillahi, H.2    Poolman, J.T.3    Leinonen, M.4
  • 38
    • 0029069967 scopus 로고
    • Porin activity and sequence analysis of a 31-kilodaltonTreponema pallidum subsp.pallidum rare outer membrane protein (Tromp1)
    • Blanco DR, Champion CI, Exner MM, Erdjument-Bromage H, Hancock REW, Tempst P, et al. Porin activity and sequence analysis of a 31-kilodaltonTreponema pallidum subsp.pallidum rare outer membrane protein (Tromp1). J Bacteriol 1995;177:3556-62.
    • (1995) J Bacteriol , vol.177 , pp. 3556-3562
    • Blanco, D.R.1    Champion, C.I.2    Exner, M.M.3    Erdjument-Bromage, H.4    Hancock, R.E.W.5    Tempst, P.6
  • 41
    • 0017177825 scopus 로고
    • Humoral immunity in experimental syphilis: II. The relationship of neutralizing factors in immune serum to acquired resistance
    • Bishop NH, Miller JN. Humoral immunity in experimental syphilis: II. The relationship of neutralizing factors in immune serum to acquired resistance. J Immunol 1976;117:197-207.
    • (1976) J Immunol , vol.117 , pp. 197-207
    • Bishop, N.H.1    Miller, J.N.2
  • 42
    • 0025270698 scopus 로고
    • Phagocytosis of opsonized Treponema pallidum subsp. pallidum proceeds slowly
    • Alder JD, Friess L, Tengowski M, Schell RF. Phagocytosis of opsonized Treponema pallidum subsp. pallidum proceeds slowly. Infect Immun 1990;58:1167-73.
    • (1990) Infect Immun , vol.58 , pp. 1167-1173
    • Alder, J.D.1    Friess, L.2    Tengowski, M.3    Schell, R.F.4
  • 43
    • 0018141476 scopus 로고
    • Demonstration of the in vitro phagocytosis of Treponema pallidum by rabbit peritoneal macrophages
    • Lukehart SA, Miller JN. Demonstration of the in vitro phagocytosis of Treponema pallidum by rabbit peritoneal macrophages. J Immunol 1978;121:2014-24.
    • (1978) J Immunol , vol.121 , pp. 2014-2024
    • Lukehart, S.A.1    Miller, J.N.2
  • 44
    • 0029805178 scopus 로고    scopus 로고
    • Recombinant Treponema pallidum rare outer membrane protein 1 (Tromp1) expressed in Escherichia coli has porin activity and surface antigenic exposure
    • Blanco DR, Champion CI, Exner MM, Shang ES, Skare JT, Hancock REW, et al. Recombinant Treponema pallidum rare outer membrane protein 1 (Tromp1) expressed in Escherichia coli has porin activity and surface antigenic exposure. J Bacteriol 1996;178:6685-92.
    • (1996) J Bacteriol , vol.178 , pp. 6685-6692
    • Blanco, D.R.1    Champion, C.I.2    Exner, M.M.3    Shang, E.S.4    Skare, J.T.5    Hancock, R.E.W.6
  • 45
    • 0023408581 scopus 로고
    • Lipopolysaccharide tightly bound to porin monomers and trimers from Escherichia coli K-12
    • Rocque WJ, Coughlin RT, McGroarty EJ. Lipopolysaccharide tightly bound to porin monomers and trimers from Escherichia coli K-12. J Bacteriol 1987;169:4003-10.
    • (1987) J Bacteriol , vol.169 , pp. 4003-4010
    • Rocque, W.J.1    Coughlin, R.T.2    McGroarty, E.J.3
  • 46
    • 0031039160 scopus 로고    scopus 로고
    • Sequence analysis and recombinant expression of a 28-kDa Treponema pallidum subsp. pallidum rare outer membrane protein (Tromp2)
    • In press
    • Champion CI, Blanco DR, Erdjument-Bromage H, Exner MM, Hancock REW, Tempst P, et al. Sequence analysis and recombinant expression of a 28-kDa Treponema pallidum subsp. pallidum rare outer membrane protein (Tromp2). J Bacteriol. In press.
    • J Bacteriol.
    • Champion, C.I.1    Blanco, D.R.2    Erdjument-Bromage, H.3    Exner, M.M.4    Hancock, R.E.W.5    Tempst, P.6
  • 47
    • 0011202990 scopus 로고
    • Humoral immune mechanisms in acquired syphilis
    • Schell RF, Musher DM, editors. New York: Marcel Dekker
    • Bishop NH, Miller JN. Humoral immune mechanisms in acquired syphilis. In: Schell RF, Musher DM, editors. Pathogenesis and immunology of treponemal infection. New York: Marcel Dekker, 1983:241-69.
    • (1983) Pathogenesis and Immunology of Treponemal Infection , pp. 241-269
    • Bishop, N.H.1    Miller, J.N.2


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