Effect of use of 0.05% cetylpyridinium chloride mouthwash on normal oral flora

Journal of Dentistry

Volumn 25, Issue 1, 1997, Pages 35-40

  Radford, J R ^a   Beighton, D ^b   Nugent, Z ^c   Jackson, R J ^d  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c DUNDEE DENTAL HOSPITAL AND SCHOOL   (United Kingdom)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

CPC mouthwash; Extraneous bacteria; Oral flora

Indexed keywords

CETYLPYRIDINIUM SALT; TOPICAL ANTIINFECTIVE AGENT;

ANAEROBIC BACTERIUM; ANALYSIS OF VARIANCE; ARTICLE; BACTERIAL COUNT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HUMAN; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; MOUTH; MOUTH HYGIENE; NONPARAMETRIC TEST; RANDOMIZED CONTROLLED TRIAL; YEAST;

ANALYSIS OF VARIANCE; ANTI-INFECTIVE AGENTS, LOCAL; BACTERIA, ANAEROBIC; CETYLPYRIDINIUM; COLONY COUNT, MICROBIAL; DOUBLE-BLIND METHOD; HUMANS; MICROBIAL SENSITIVITY TESTS; MOUTH; MOUTHWASHES; STATISTICS, NONPARAMETRIC; YEASTS;

EID: 0030623405     PISSN: 03005712     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-5712(95)00116-6     Document Type: Article

References (31)

1. Sturzenberger OP, Leonard GJ. The effect of a mouthwash as adjunct in tooth cleaning. J Periodont 1969; 40: 299-304.
2. Alexander AG. A study of the distribution of supra and subgingival calculus, bacterial plaque and gingival inflammation in the mouths of 400 individuals. J Periodont 1971; 42: 21-28.
3. Addy M, Griffiths G, Dummer PMH, Kingdom A, Shaw WC. The distribution of plaque and gingivitis and the influence of toothbrushing hand in a group of South Wales 11-12 year-old children. J Clin Periodont 1987: 14; 564-572.
4. Seymour RA, Heasman PA. Anti-plaque and anti-calculus agents. In: Drugs, Diseases and the Periodontium, Chapter 9. New York: Oxford Medical Publications, 1992.
5. Baker Z, Harrison RW, Miller BF. The bacterial action of synthetic detergents. J. Exp. Med. 1941: 74: 611-620.
6. Ashley FP, Skinner A, Jackson P, Woods A, Wilson RF. The effects of a 0.1% cetylpyridinium chloride mouthrinse on plaque and gingivitis in adult subjects. Br Dent J 1984: 157: 191-196.
7. Holbeche JD, Ruljancich MK, Reade PC. A clinical trial of the efficacy of a cetylpyridinium chloride-based mouthwash. 1. Effect on plaque accumulation and gingival condition. Aust Dent J 1975; 20: 397-404.
8. Volpe AR, Kupczak LJ, Brant JH, King WJ, Kestenbaum RC, Schlissel HJ. Antimicrobial control of bacterial plaque and calculus, and the effects of these agents on oral flora. J Dent Res 1969; 48: 832-841.
9. Bonesvoll P, Gjermo P. A comparison between chlorhexidine and some quaternary ammonium compounds with regard to retention, salivary concentration and plaque-inhibiting effect in the human mouth after mouth rinses. Arch Oral Biol 1978; 23: 289-294.
10. Ciancio SG, Mather ML, Bunnell HL. Clinical evaluation of a quaternary ammonium-containing mouthrinse. J Periodont 1975; 46: 397-401.
11. American Dental Association. Plaque: Current approaches to prevention and control. J Am Dent Assoc 1984; 109: 690-702.
12. American Dental Association, Council on Dental Therapeutics. Guidelines for acceptance of chemotherapeutic products for the control of supragingival dental plaque and gingivitis. J Am Dent Assoc 1986; 112: 529-532.
13. Beighton D. Hellyer PH, Lynch EJR, Heath MR. Salivary levels of mutans streptococci, lactobacilli, yeasts and root caries prevalence in non-institutionalized elderly dental patients. Comm Dent Oral Epidem 1991; 19: 302-307.
14. Hull PS. Chemical inhibition of plaque. J Clin Periodont 1980; 7: 431-442.
15. Kornman KS. The role of supragingival plaque in the prevention and treatment of periodontal diseases. A review of current concepts. J Periodont Res 1986; 21 (16 Suppl.): 5-22.
16. Addy M. Chlorhexidine compared with other locally delivered antimicrobials. A short review. J Clin Periodont 1986; 13: 957-964.
17. Lang NP, Brecx MC. Chlorhexidine digluconate - an agent for chemical plaque control and prevention of gingival inflammation. J Periodont Res 1986; 21 (16 Suppl.): 74-89.
18. Marsh PD. Host defences and microbial homeostasis: role of microbial interactions. J Dent Res 1989; 68: 1567-1575.
19. Lacey RW, Lord VL, Howson GL, Luxton DEA, Trotter IS. Double blind study to compare the selection of antibiotic resistance by amoxycillin or cephadrine in the commensal flora. Lancet 1983; ii: 529-532.
20. Briner WW, Grossman E. Buckner RY et al. Effect of chlorhexidine gluconate mouthrinse on plaque bacteria. J Periodont Res 1986; 21 (16 Suppl.): 44-52.
21. Schiott CR, Briner, WW, Kirkland JJ, Löe H. Two years' oral use of chlorhexidine in man. III. Changes in sensitivity of the salivary flora. J Periodont Res 1976; 11: 153-157.
22. Minah GE, DePaola LG, Overholser CD et al. Effects of 6 months' use of an antiseptic mouthrinse on supragingival dental plaque microflora. J Clin Periodont 1989; 16: 347-352.
23. Jones CL, Ritchie JA, Marsh PD, van der Ouderaa F. The effect of long-term use of a dentifrice containing zinc citrate and a non-ionic agent on the oral flora. J Dent Res 1988; 67: 46-50.
24. Stephen KW, Saxton CA, Jones CL, Ritchie JA, Morrison T. Control of gingivitis and calculus by a dentrifrice containing a zinc salt and Triclosan. J Periodont Res 1990; 61: 674-679.
25. Briner WW, Grossman E, Buckner RY et al. Assessment of susceptibility of plaque bacteria to chlorhexidine after six months' oral use. J Periodont Res 1986; 21 (16 Suppl.): 53-59.
26. De la Rosa M, Sturzenburger OP. Clinical reduction of gingivitis through the use of a mouthwash containing two quaternary ammonium compounds. J Periodont 1976; 47: 535-537.
27. Lobene RR, Kashket S, Soparker, PM, Shloss J, Sabine ZM. The effect of cetylpyridinium chloride on human plaque bacteria and gingivitis. Pharmac Ther Dent 1979; 14: 33-47.
28. Marsh PD. Microbiological aspects of the chemical control of plaque and gingivitis. J Dent Res 1992; 71: 1431-1438.
29. Radford JR, Homer KA, Naylor MN, Beighton D. Inhibition of sub-gingival plaque protease activity by chlorhexidine. Arch Oral Biol 1992; 37: 245-248.
30. Bradshaw DJ, Marsh PD, Watson GK, Cummins D. The effects of Triclosan and zinc citrate, alone and in combination, on a community of oral bacteria growtn in vitro. J Dent Res 1993; 72: 25-30.
31. Addy M, Jenkins PM. Chlorhexidine staining: In vitro studies of beverages as aetiological factors. IRCS Med Sci 1977; 5: 393.