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We thank P. Kollman and the participants in the meeting, "Modeling of Biological Systems," which inspired this article, and NSF, which funded the workshop. Supported by NASA grant NAGW 4688 and the Andrew Mellon Foundation (S.L.), NSF grant DEB 9629236 (A.H.), the Wellcome Trust (B.G.), NIH grants RR06555 and AI28433 (A.S.P.), and the Jeanne M. Sullivan and Joseph P. Sullivan Foundation. D. Deutschman provided useful comments. Most of all, we thank A. Bordvik, who brought order to a chaotic sequence of drafts of this manuscript.
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