Tunicamycin reduces wool growth by slowing the mitotic activity of wool follicles

Australian Journal of Agriculture Research

Volumn 48, Issue 3, 1997, Pages 331-336

  Davies, S C ^a   Williams, I H ^a   White, C L ^b   Hocking Edwards, J E ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b CSIRO   (Australia)

Author keywords

sheep; skin; toxicity

Indexed keywords

ANIMALIA; LOLIUM MULTIFLORUM; OVIS; OVIS ARIES;

SHEEP; WOOL;

EID: 0030618041     PISSN: 00049409     EISSN: None     Source Type: Journal    
DOI: 10.1071/A96055     Document Type: Article

References (28)

1. Berry, P. H., Howell, J. M., and Cook, R. D. (1980a). Morphological changes in the central nervous system of sheep affected with experimental annual ryegrass (Lolium rigidum) toxicity. Journal of Comparative Pathology 90, 603-17.
2. Berry, P. H., Howell, J. M., Cook, R. D., Richards, R. B., and Peet, R. L. (1980b). Central nervous system changes in sheep and cattle affected with natural or experimental annual ryegrass toxicity. Australian Veterinary Journal 56, 402-3.
3. Carter, H. B., and Clarke, W. H. (1957). The hair follicle group and skin follicle population of Australian Merino sheep. Australian Journal of Agricultural Research 8, 91-108.
4. Davies, S. C., White, C. L., Williams, I. H., Allen, J. G., and Croker, K. P. (1996). Sub-lethal exposure to corynetoxins affects production of grazing sheep. Australian Journal of Experimental Agriculture 36, 649-55.
5. Downes, A. M., Clarke, W. H., and Dagg, T. C. (1967). Use of radioisotopes in the measurement of wool growth. Atomic Energy in Australia 2, 2-7.
6. Finnie, J. W. (1991). Scanning electron microscopy of ovine endothelial cells in vitro exposed to tunicamycin. Journal of Comparative Pathology 105, 225-8.
7. Finnie, J. W., Hooper, P., and Ehrlich, D. (1985). Neuropathological changes in experimental annual ryegrass toxicity. Neuroscience Letters 19, S62.
8. Finnie, J. W., and Mukherjee, T. M. (1986). Ultrastructural changes in the cerebellum of nursling rats given corynetoxin, the aetiological agent of annual ryegrass toxicity. Journal of Comparative Pathology 96, 205-16.
9. Finnie, J. W., and Mukherjee, T. M. (1987). Ultrastructural changes in cerebral blood vessels of sheep injected with tunicamycin. Journal of Comparative Pathology 97, 217-20.
10. Finnie, J. W., and O'Shea, J. D. (1988). Pathological and patho-genetic changes in the central nervous system of guinea pigs given tunicamycin. Acta neuropathologica 75, 411-21.
11. Frisch, A., Levkowitw, H., and Loyter, A. (1976). Inhibition of conjugation and cell division in Tetrahymena pyriformis by tunicamycin: a possible requirement of glycoprotein synthesis for induction of conjugation. Biochemical and Biophysical Research Communications 72, 138-45.
12. Harris, P. M., Dellow, D. W., and Sinclair, B. R. (1988). Measurement of blood flow and amino acid metabolism in the skin of sheep. Proceedings of the New Zealand Society of Animal Production 48, 187-9.
13. Harris, P. M., Dellow, D. W., and Sinclair, B. R. (1989) Preliminary 'in vivo' measurements of protein and energy metabolism in the skin of sheep. Australian Journal of Agricultural Research 40, 879-88.
14. Hemming, F. W. (1982). Control and manipulation of the phosphodolichol pathway of protein N-glycosylation. Bioscience Reports 2, 203-21.
15. Hynd, P. I. (1989). Factors influencing cellular events in the wool follicle. In 'The Biology of Wool and Hair.' (Eds G. E. Rogers, P. J. Reis, K. A. Ward, and R. C. Marshall.) pp. 169-84. (Chapman and Hall Ltd: London.)
16. Hynd, P. I., Schlink, A. C., Phillips, P. M., and Scobie, D. R. (1986). Mitotic activity in cells of the wool follicle bulb. Australian Journal of Biological Science 39, 329-39.
17. Jago, M. V. (1984). Causative action of corynetoxins in annual ryegrass toxicity. In 'Australia-U.S.A. Poisonous Plants Symposium'. (Eds A. A. Seawright, M. P. Hegarty, L. F. James, and R. F. Keeler.) pp. 569-77. (Queensland Poisonous Plants Committee: Brisbane.)
18. Jago, M. V., and Culvenor, C. C. J. (1987). Tunicamycin and corynetoxin poisoning in sheep. Australian Veterinary Journal 64, 232-5.
19. Jago, M. V., Payne, A. L., Peterson, J. E. and Bagust, T. J. (1983) Inhibition of glycosylation by corynetoxin, the causative agent of annual ryegrass toxicity: a comparison with tunicamycin. Chemico-Biological Interactions 45, 223-34.
20. McDonald, B. J., Broadmeadow, A. C. C., Hoey, W. A., and Hopkins, P. S. (1982). Preparation of an isolated cutaneous infusion in sheep. Research in Veterinary Science 33, 123-4.
21. Mills, P. C., Ng, J. C., Seawright, A. A., and Auer, D. E. (1993). Vascular leakage induced by histamine, bradykinin, serotonin and prostaglandin E2 in greyhounds. Australian Veterinary Journal 70, 21-4.
22. Peterson, J. E., and Jago, M. V. (1977). Brain damage by extracts of parasitised annual ryegrass (Lolium rigidum) in nursling rats. Australian Journal of Experimental Biology and Medical Science 55, 233-44.
23. Riley, I. T., and Ophel, K. M. (1992). Clavibacter toxicus sp. nov., the bacterium responsible for annual ryegrass toxicity in Australia. International Journal of Systematic Bacteriology 42, 64-68
24. Schinckel, P. G. (1961). Mitotic activity in wool follicle bulbs. Australian Journal of Biological Research 14, 659-76.
25. Struck, D. K., and Lennarz, W. J. (1980). The function of saccharide-lipids in synthesis of glycoproteins. In 'The Biochemistry of Glycoproteins and Proteoglycans'. (Ed W. J. Lennarz.) pp. 35-83. (Plenum Press: New York.)
26. Takatsuki, A., Shimizu, K., and Tamura, G. (1972). Effect of tunicamycin on microorganisms. Morphological changes and degradation of RNA and DNA induced by tunicamycin. Journal of Antibiotics 25, 75-85.
27. Takatsuki, A., and Tamura, G. (1971). Effect of tunicamycin on the synthesis of macromolecules in cultures of chick embryo fibroblasts infected with Newcastle disease virus. The Journal of Antibiotics 24, 785-94.
28. Zoltie, N., Hynd, P. I., and Kuchel, T. (1988). Anatomy of the blood supply to the flank of the sheep. Research in Veterinary Science 45, 307-10.