Ca2+/calmodulin-dependent cyclic GMP phosphodiesterase activity in granule neurons and astrocytes from rat cerebellum

European Journal of Pharmacology

Volumn 323, Issue 1, 1997, Pages 119-125

  Agulló, Luis ^a   García, Agustina ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Astrocyte; Ca2+; cGMP; Granule cell; Phosphodiesterase

Indexed keywords

4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; CALMIDAZOLIUM; CALMODULIN; CALMODULIN INHIBITOR; CYCLIC GMP; CYCLIC GMP PHOSPHODIESTERASE; ISOBUTYLMETHYLXANTHINE; NICARDIPINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; VINPOCETINE; ZAPRINAST; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PHOSPHODIESTERASE; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; PHOSPHODIESTERASE (CALCIUM,CALMODULIN);

ANIMAL CELL; ARTICLE; ASTROCYTE; CALCIUM CELL LEVEL; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVITY; GRANULE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GRANULOCYTE; LD 50; METABOLISM; NERVE CELL; SPRAGUE DAWLEY RAT;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; ASTROCYTES; CALCIUM; CALMODULIN; CELLS, CULTURED; CEREBELLUM; CYCLIC GMP; ENZYME INHIBITORS; GRANULOCYTES; IMIDAZOLES; LETHAL DOSE 50; NEURONS; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030615278     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00019-8     Document Type: Article

References (29)

1. Agulló, L., Baltrons, M.A., García A., 1995. Calcium-dependent nitric oxide formation in glial cells. Brain Res. 686, 160-168.
2. Arbonés, M.L., Ribera, J., Agulló, L., Baltrons, M.A., Casanovas, A., Riveros-Moreno, V., García, A., 1996. Characteristics of nitric oxide synthase type I of rat cerebellar astrocytes. Glia 18, 224-232.
3. Beavo, J.A., 1995. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol. Rev. 75, 725-748.
4. Bredt, D.S., Hwang, P.M., Snyder, S.H., 1990. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347, 768-770.
5. Dawson, T.M., Bredt, D.S., Fotuhi, M., Hwang, P.M., Snyder, S.H., 1991. Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc. Natl. Acad. Sci. USA 88, 7797-7801.
6. De Vente, J., Bol, J.G.J.M., Berkelmans, H.S., Schipper, J., Steinbusch, H.M.W., 1990. Immunocytochemistry of cGMP in the cerebellum of the immature, adult, and aged rat: the involvement of nitric oxide. A micropharmacological study. Eur. J. Neurosci. 2, 845-862.
7. Garthwaite, J., Boulton, C.L., 1995. Nitric oxide signaling in the central nervous system. Annu. Rev. Physiol. 57, 683-706.
8. Garthwaite, J., Garthwaite, G., 1987. Cellular origins of cyclic GMP responses to excitatory amino acid receptor agonists in rat cerebellum in vitro. J. Neurochem. 48, 29-39.
9. Hidaka, H., Asano, T., 1976. Platelet cyclic 3′:5′-nucleotide phosphodiesterase released by thrombin and calcium ionophore. J. Biol. Chem. 251, 7508-7516.
10. Kiedrowski, L., Costa, E., Wroblewski, J.T., 1992. Glutamate receptor agonists stimulate nitric oxide synthase in primary cultures of cerebellar granule cells. J. Neurochem. 58, 335-341.
11. Kincaid, R.L., Manganiello, V.C., Vaughan, M., 1981a. Calmodulin-activated cyclic nucleotide phosphodiesterase from brain. Changes in molecular size assessed by gel filtration and electrophoresis. J. Biol. Chem. 256, 11345-11350.
12. Kincaid, R.L., Kempner, E., Manganiello, V.C., Osborne Jr., J.C., Vaughan, M., 1981b. Calmodulin-activated cyclic nucleotide phosphodiesterase from brain. Relationship of subunit structure to activity assessed by radiation inactivation. J. Biol. Chem. 256, 11351-11355.
13. Kincaid, R.L., Mangianello, V.C., Odya, C.E., Osborne Jr., J.C., Stith-Coleman, I.E., Danello, M.A., Vaughan, M., 1984. Purification and properties of calmodulin-stimulated phosphodiesterase from mammalian brain. J. Biol. Chem. 259, 5158-5166.
14. Knowles, R.G., Palacios, M., Palmer, R.M.J., Moncada, S., 1989. Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase. Proc. Natl. Acad. Sci. USA 86, 5159-5162.
15. Kugler, P., Drenckhahn, D., 1996. Astrocytes and Bergmann glia as an important site of nitric oxide synthase I. Glia 16, 165-173.
16. Lugnier, C., Schoeffter, P., Le Bec, A., Strouthou, E., Stoclet, J.C., 1986. Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta. Biochem. Pharmacol. 35, 1743-1751.
17. 2+, calmodulin-dependent cyclic nucleotide phosphodiesterases from rabbit aorta and brain to dihydropyridine calcium channel blockers. Biochem. Biophys. Res. Commun. 148, 1468-1474.
18. 2+. J. Neurochem. 59, 2024-2029.
19. Nicholson, C.D., Jackman, S.A., Wilke, R., 1989. The ability of denbufylline to inhibit cyclic nucleotide phosphodiesterase and its affinity for adenosine receptors and the adenosine re-uptake site. Br. J. Pharmacol. 97, 889-897.
20. Polli, J.W., Kincaid, R.L., 1994. Expression of a calmodulin-dependent phosphodiesterase isoform (PDE1B1) correlates with brain regions having extensive dopaminergic innervation. J. Neurosci. 14, 1251-1261.
21. Saeki, T., Saito, I., 1993. Isolation of cyclic nucleotide phosphodiesterase isozymes from pig aorta. Biochem. Pharmacol. 46, 833-839.
22. Schmidt, H.H.H.W., Gagne, G.D., Nakane, M., Pollock, J.S., Miller, M.F., Murad, F., 1992. Mapping of neural nitric oxide synthase in the rat suggests frequent co-localisation with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction. J. Histochem. Cytochem. 40, 1439-1456.
23. Sharma, R.K., Kalra, J., 1994. Characterization of calmodulin-dependent cyclic nucleotide phosphodiesterase isoenzymes. Biochem. J. 299, 97-100.
24. Sharma, R.K., Adachi, A., Adachi, K., Wang, J.H., 1984. Demonstration of bovine brain calmodulin-dependent cyclic nucleotide phosphodiesterase isozymes by monoclonal antibodies. J. Biol. Chem. 259, 9248-9254.
25. 2+-calmodulin-stimulated cyclic GMP phosphodiesterase from bovine brain. Biochemistry 24, 672-677.
26. Tucker, M.M., Robinson Jr., J.B., Stellwagen, E., 1981. The effect of proteolysis on the calmodulin activation of cyclic nucleotide phosphodiesterase. J. Biol. Chem. 256, 9051-9058.
27. Weishaar, R.E., Burrows, S.D., Kobylarz, D.C., Quade, M.M., Evans, D.B., 1986. Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets. Isolation, characterization, and effects of various reference phosphodiesterase inhibitors and cardiotonic agents. Biochem. Pharmacol. 35, 787-800.
28. Yan, C., Beavo, J.A., 1994. Molecular cloning and cellular distribution of the 75 kDa calmodulin-dependent phosphodiesterase. FASEB J. 8, S470.
29. Yan, C., Bentley, J.K., Sonnenburg, W.K., Beavo, J.A., 1994. Differential expression of the 61 kDa and 63 kDa calmodulin-dependent phosphodiesterases in the mouse brain. J. Neurosci. 14, 973-984.