Retention of soluble 99mTc-DTPA in the human lung: 24-H postdeposition

Journal of Applied Physiology

Volumn 82, Issue 4, 1997, Pages 1378-1382

  Foster, W Michael ^a,b   Stetkiewicz, Pamela T ^a   Freed, Arthur N ^a  

^a Johns Hopkins University   (United States)

^b No 7006 Hygiene Bldg ^*  (United States)

Author keywords

airway; ozone; respiratory epithelium; technetium 99m labeled diethylenetriaminepentaacetate

Indexed keywords

OZONE; PENTETATE TECHNETIUM TC 99M; XENON 133; MICROSPHERE; RADIOPHARMACEUTICAL AGENT;

ADULT; AEROSOL; ARTICLE; CLINICAL PROTOCOL; DRUG RETENTION; FEMALE; HUMAN; HUMAN EXPERIMENT; INHALATIONAL DRUG ADMINISTRATION; LUNG CLEARANCE; LUNG DEPOSIT; LUNG PARENCHYMA; MALE; MOUTH BREATHING; NEBULIZATION; NORMAL HUMAN; PRIORITY JOURNAL; REBREATHING; RESPIRATORY EPITHELIUM; SCINTILLATION CAMERA; CLINICAL TRIAL; EPITHELIUM; LUNG; METABOLISM; RESIDUAL VOLUME; SCINTISCANNING;

ADMINISTRATION, INHALATION; ADULT; AEROSOLS; EPITHELIUM; FEMALE; HUMANS; LUNG; MALE; MICROSPHERES; RADIONUCLIDE IMAGING; RADIOPHARMACEUTICALS; RESIDUAL VOLUME; TECHNETIUM TC 99M PENTETATE;

EID: 0030615257     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1997.82.4.1378     Document Type: Article

References (17)

1. 99mTc-labeled compounds. J. Nucl. Med. 14: 793-797, 1973.
2. Effros, R. M., and G. R. Mason. Measurements of pulmonary epithelial permeability in vivo. Am. Rev. Respir. Dis. 127: S59-S65, 1983.
3. Foster, W. M., J. A. Silver, and M. L. Groth. Exposure to ozone alters regional function and particle dosimetry in the human lung. J. Appl. Physiol. 75: 1938-1945, 1993.
4. Foster, W. M., and P. T. Stetkiewicz. Regional clearance of solute from the respiratory epithelia: 18-20 h postexposure to ozone. J. Appl. Physiol. 81: 1143-1149, 1996.
5. Freed, A. N., C. Omori, W. C. Hubbard, and N. Adkinson. Dry air- and hypertonic aerosol-induced bronchoconstriction and cellular responses in canine lung periphery. Eur. Respir. J. 7: 1308-1316, 1994.
6. 99mTc-DTPA. Danish Med. Bull. 38: 101-113, 1991.
7. Groth, M. L., and W. M. Foster. Aerosolized atropine sulfate: influence of inhalation pattern on effective blockade of vagal airway tone. Am. Rev. Respir. Dis. 145: 215-219, 1992.
8. Man, S. F. P., I. H. Ahmed, G. C. W. Man, and A. Nguyen. Characteristics of pertechnetate movement across the canine tracheal epithelium. Am. Rev. Respir. Dis. 131: 90-93, 1985.
9. Marks, J. D., J. M. Luce, N. M. Lazar, J. N.-S. Wu, A. Lipavsky, and J. F. Murray. Effect of increases in lung volume on clearance of aerosolized solute from human lungs. J. Appl. Physiol. 59: 1242-1248, 1985.
10. 113mIn-DTPA aerosol clearances in humans. Am. Rev. Respir. Dis. 136: 1112-1116, 1987.
11. 99mTc-DTPA: a noninvasive assessment of epithelial integrity. Lung 165: 1-16, 1987.
12. O'Brodovich, H., G. Coates, J. Kay, and D. Muysson. Simultaneous measurement of lung clearance rates for Tc- and In-DTPA in normal and damaged lungs. J. Appl. Physiol. 66: 2293-2297, 1989.
13. 99mTc-DTPA from air spaces during lung inflation and lung injury. J. Appl. Physiol. 63: 1136-1141, 1987.
14. Rinderknecht, J., L. Shapiro, M. Krauthammer, G. Taplin, K. Wasserman, and B. M. Effros. Accelerated clearance of small solutes from the lungs in interstitial lung disease. Am. Rev. Respir. Dis. 121: 105-117, 1980.
15. Rizk, N. W., J. M. Luce, J. M. Hoeffel, D. C. Price, and J. F. Murray. Site of deposition and factors affecting clearance of aerosolized solute from canine lungs. J. Appl. Physiol. 56: 723-729, 1984.
16. 14C-DTPA in human volunteers after inhalation or intravenous injection Health Phys. 44: 45-52, 1983.
17. Staub, N. C., R. W. Hyde, and E. Crandall. Workshop on techniques to evaluate lung alveolar-microvascular injury. Am. Rev. Respir. Dis. 141: 1071-1077, 1990.