Modification of the binding of [3H]MK-801 to brain regions and spinal cord of rats treated chronically with U-50,488H, a κ-opioid receptor agonist

Brain Research

Volumn 749, Issue 2, 1997, Pages 347-350

  Bhargava, Hemendra N ^a   Kumar, Shailendra ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

opioid receptor agonist; 3H MK 801 binding; brain region; rat; spinal cord; tolerance; U 50,488H

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; DIZOCILPINE; KAPPA OPIATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OPIATE AGONIST; RADIOLIGAND; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ANALGESIC AGENT; DIZOCILPINE MALEATE; PYRROLIDINE DERIVATIVE; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DRUG TOLERANCE; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SPINAL CORD; AMYGDALOID NUCLEUS; ANIMAL; ANTIBODY SPECIFICITY; BRAIN; CELL MEMBRANE; CORPUS STRIATUM; DRUG EFFECT; DRUG POTENTIATION; HIPPOCAMPUS; KINETICS; MEDULLA OBLONGATA; MESENCEPHALON; METABOLISM; PONS; RADIOASSAY; SPRAGUE DAWLEY RAT;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; AMYGDALA; ANALGESICS; ANIMALS; BRAIN; CELL MEMBRANE; CORPUS STRIATUM; DIZOCILPINE MALEATE; HIPPOCAMPUS; KINETICS; MALE; MEDULLA OBLONGATA; MESENCEPHALON; ORGAN SPECIFICITY; PONS; PYRROLIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, OPIOID, KAPPA; SPINAL CORD; TRITIUM;

EID: 0030615003     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01418-7     Document Type: Article

References (16)

1. Aimone, L.D. and Gebhart, G.F., Stimulation-produced spinal inhibition from the midbrain in the rat is mediated by an excitatory amino acid neurotransmitter in the medial medulla, J. Neurosci., 6 (1986) 1803-1813.
2. Behbehani, M.M. and Fields, H.L., Evidence that excitatory connection between the periaqueductal gray and the nucleus raphe magnus mediales stimulation produced analgesia, Brain Res., 170 (1979) 85-93.
3. Bhargava, H.N., Diversity of agents that modify tolerance, physical dependence, abstinence syndrome and self-administrative behavior, Pharmacol. Rev., 46 (1994) 293-324.
4. Bhargava, H.N., Noncompetitive antagonism of NMDA receptor inhibits tolerance to U-50,488H, a κ-opiate receptor agonist in the rat, Gen. Pharmacol., 26 (1995) 1055-1060.
5. Bhargava, H.N., Gulati, A. and Ramarao, P., Effect of chronic administration of U-50,488H on tolerance to its pharmacological actions and on multiple opioid receptors in rat brain regions and spinal cord. J. Pharmacol. Exp. Ther., 251 (1989) 21-26.
6. Bhargava, H.N. and Matwyshyn, G.A., Dizocilpine (MK-801) blocks tolerance to the analgesic but not to the hyperthermic effect of morphine in the rat, Pharmacology, 47 (1993) 344-350.
7. Bhargava, H.N., Reddy, P.L. and Gudehithlu, K.P., Down-regulation of N-methyl-D-aspartate (NMDA) receptors of brain regions and spinal cord of rats treated chronically with morphine, Gen. Pharmacol., 26 (1995) 131-136.
8. Bhargava, H.N. and Thorat. S.N., Effect of dizocilpine (MK-801) on analgesia and tolerance induced by U-50,488H, a κ-opioid receptor agonist in the mouse, Brain Res., 649 (1994) 111-116.
9. 2-opioid receptor agonist in mice. Brain Res., 719 (1996) 56-61.
10. 3H]MK-801 to brain regions and spinal cord of mice treated chronically with morphine. Gen. Pharmacol., 27 (1996) 91-94.
11. 3H]MK-801 to brain regions and spinal cord of the rat. Brain Res., 639 (1994) 269-274.
12. Marek, P., Ben-Eliyahu, S., Gold, M. and Liebeskind, J.C., Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the rat. Brain Res., 547 (1991) 77-81.
13. Trujillo, K.A. and Akil, H., Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801, Science, 251 (1991) 85-87.
14. Urca, G., Nahin, R.L. and Liebeskind, J.C., Glutamate-induced analgesia: blockade and potentiation by naloxone, Brain Res., 192, (1980) 523-530.
15. 3H]MK-801 labels a site on the N-methyl-D-aspartate receptor channel complex in rat brain membranes, J. Neurochem., 50 (1988) 274-281.
16. 1-opioid receptor agonist in mice. Peptides, 17 (1996) 233-236.