Proton-decoupled 19F spectroscopy of 5-FU catabolites in human liver

Magnetic Resonance in Medicine

Volumn 37, Issue 3, 1997, Pages 321-326

  Murphy Boesch, Joseph ^a,b   Li, Chun Wei ^a   He, Libo ^a   Padavic Shaller, Kristin A ^a   Negendank, William ^a   Brown, Truman R ^a  

^a Dept of NMR and Med Spectroscopy ^*  (United States)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

19F spectroscopy; chemical shift imaging; human liver; proton decoupling

Indexed keywords

AMINO ACIDS; CHEMOTHERAPY; IMAGE ENHANCEMENT;

5-FLUOROURACIL (5-FU); CHEMICAL SHIFT IMAGING; FREQUENCY NOISE; HUMAN LIVER; NON-LOCALIZED; PROTON DECOUPLING; SURFACE COILS; THREE DIMENSIONAL CHEMICALS;

CHEMICAL SHIFT;

FLUOROURACIL; ALPHA FLUORO BETA ALANINE; ALPHA-FLUORO-BETA-ALANINE; BETA ALANINE; DRUG DERIVATIVE;

ARTICLE; DIAGNOSTIC IMAGING; IMAGE ENHANCEMENT; LIVER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL NOISE RATIO; SPECTROSCOPY; HUMAN; IMAGE QUALITY; INSTRUMENTATION; METABOLISM; METHODOLOGY; URINE;

BETA-ALANINE; FLUOROURACIL; HUMANS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; PHANTOMS, IMAGING;

EID: 0030614889     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1910370302     Document Type: Article

References (11)

1. W. Wolf, M.J. Albright, M. S. Silver, H. Weber, U. Reichardt, R. Sauer, Fluorine-19 NMR spectroscopic studies of the metabolism of 5-fluorouracil in the liver of patients undergoing chemotherapy. Magn. Reson. Imaging 5, 165-169 (1987).
2. 19F nuclear magnetic resonance spectroscopy, for patients receiving chemotherapy with or without methotrexate pretreatment. Cancer Res. 48, 1680-1688 (1988).
3. 1H] Nuclear Overhauser effect and proton decoupling of 5-fluorouracil and α-fluoro-β-alanine. J. Magn. Reson. Series B 108, 155-164 (1995).
4. 1H] Nuclear Overhauser effect of 5-fluorouracil and α-fluoro-β-alanine, in "Proc., SMR, 2nd Annual Meeting, San Francisco, 1994," p. 1356.
5. J. Murphy-Boesch, R. Stoyanova, R. Srinivasan, T. Willard, D. Vigneron, S. Nelson, J. S. Taylor, T. R. Brown. Proton-decoupled P-31 chemical shift imaging of the human brain in normal volunteers. NMR Biomed. 6, 173-180 (1993).
6. 1 relaxation times of phosphorylated metabolites in human calf muscle at 1.5 Tesla. Magn. Reson. Med. 33, 417-421 (1995).
7. W. G. Negendank, K. A. Padavic-Shaller, C-W. Li, J. Murphy-Boesch, R. Stoyanova, R. L. Krigel, R. J. Schilder, M. R. Smith, T. R. Brown, Metabolic characterization of human non-Hodgkin's lymphomas in vivo with the use of proton-decoupled phosphorus magnetic resonance spectroscopy. Cancer Res. 55, 3286-3294 (1995).
8. 19F magnetic resonance spectroscopy. Clin. Cancer Res. 2, 339-345 (1996).
9. B. Berkowitz, J. J. H. Ackerman, Proton decoupled fluorine nuclear magnetic resonance spectroscopy in situ. Biophys. J. 151, 681-685 (1987).
10. A. J. Shaka, A. J. Keeler, R. Freeman, Evaluation of a new broadband decoupling sequence: WALTZ-16. J. Magn. Reson. 53, 313-340 (1983).
11. 1H chemical shift imaging spectroscopy. J. Magn. Reson. Series B 108, 213-219 (1995).