Differential diagnosis of hürthle cell neoplasms on fine needle aspirates: Can We do any better with morphometry?

Acta Cytologica

Volumn 41, Issue 1, 1997, Pages 197-208

  Pambuccian, Stefan E ^a,b,c   Becker, Robert L ^a,b,c   Ali, Syed Z ^a,b,c   Savik, Kay ^a,b,c   Rosenthal, Dorothy L ^a,b,c  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Aspiration biopsy; H rthle cell (oxyphilic) neoplasms; Morphometry; Nucleolus; Thyroid neoplasms

Indexed keywords

ADENOCARCINOMA; AGED; ALGORITHM; ANALOG DIGITAL CONVERTER; ARTICLE; CELL SIZE; CYTOPLASM; DIFFERENTIAL DIAGNOSIS; FEMALE; HUMAN; IMAGE PROCESSING; INSTRUMENTATION; MALE; MIDDLE AGED; NEEDLE BIOPSY; NUCLEOLUS; ONCOCYTOMA; PATHOLOGY; STAINING; THYROID TUMOR; ULTRASTRUCTURE; ADENOMA; ADULT; ASPIRATION BIOPSY; CARCINOMA; CELL ULTRASTRUCTURE; CLINICAL ARTICLE; HISTOPATHOLOGY; HUMAN TISSUE; MORPHOMETRICS; PAPANICOLAOU TEST; PRIORITY JOURNAL;

ADENOCARCINOMA; ADENOMA, OXYPHILIC; AGED; ALGORITHMS; ANALOG-DIGITAL CONVERSION; BIOPSY, NEEDLE; CELL NUCLEOLUS; CELL SIZE; CYTOPLASM; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MIDDLE AGED; STAINING AND LABELING; THYROID NEOPLASMS;

EID: 0030614580     PISSN: 00015547     EISSN: 19382650     Source Type: Journal    
DOI: 10.1159/000332323     Document Type: Article

References (82)

1. Atkinson BF: Fine needle aspiration of the thyroid. Monogr Pathol 1993;35:166-199
2. Baak JPA, Van Dienst PJ, Fleege JC, Meijer GA: Practical Morphometry. In Manual of Quantitative Pathology in Cancer Diagnosis and Prognosis. Edited by JPA Baak. Berlin, Springer-Verlag, 1991, pp 531-551
3. Becker RL Jr: Standardization and quality control of quantitative microscopy in pathology. J Cell Biochem (suppl) 1993;17G:199-204
4. Beckner ME, Heffess CS, Oertel JE: Oxyphilic papillary thyroid carcinomas. Am J Clin Pathol 1995;103:280-287
5. Benoit JL, Chen D, Schultz D, Kini SR: Fine needle aspirates of Hürthle cell lesions of the thyroid: A morphometric analysis (abstr). Acta Cytol 1994;38:850
6. Bondeson L, Azavedo E, Bondeson AG, Caspersson T, Ljungberg O: Nuclear DNA content and behavior of oxyphil thyroid tumors. Cancer 1986;58:672-675
7. Bondeson L, Bondeson AG, Lindholm K, Ljungberg O, Tib-blin S: Morphometrie studies on nuclei in smears of fine needle aspirates from oxyphilic tumors of the thyroid. Acta Cytol 1983;27:437-440
8. Boon ME, Kok LP: An explanation for the variability of nuclear areas in air-dried Romanowsky-Giemsa-stained smears of follicular tumors of the thyroid (lett). Acta Cytol 1987;31:527-530
9. Boon ME, Löwhagen T, Cardozo PL, Blonk DI, Kurver PJ, Baak JP: Computation of preoperative diagnosis probability for follicular adenoma and carcinoma of the thyroid on aspiration smears. Analyt Quant Cytol 1982;4:1-5
10. Boon ME, Löwhagen T, Willems JS.:Planimetric studies on fine needle aspirates from follicular adenoma and follicular carcinoma of the thyroid. Acta Cytol 1980;24:145-148
11. Bronner MP, Clevenger CV, Edmonds PR, Lowell DM, McFarland MM, LiVolsi VA: Flow cytometric analysis of DNA content in Hürthle cell adenomas and carcinomas of the thyroid. Am J Clin Pathol 1988;89:764-769
12. Bronner MP, LiVolsi VA: Oxyphilic (Askanazy/Hürthle cell) tumors of the thyroid. Microscopic features that predict biologic behavior. Surg Pathol 1988;1:137-150
13. Caraway NP, Sneige N, Samaan NA: Diagnostic pitfalls in thyroid fine-needle aspiration: A review of 394 cases. Diagn Cytopathol 1993;9:345-350
14. Cavallari V, Maiorana A, La Rosa GL, Maiorana MC, Sci-mone S, Fano RA: Morphometric studies on fine-needle aspirates from follicular proliferative lesions of the thyroid. Pathologica 1989;81:441-446
15. Chen KT: Fine-needle aspiration cytology of papillary Hürthle cell tumors of thyroid: A report of three cases. Diagn Cytopathol 1991;7:53-56
16. Cor A, Pajer Z: Ag-NOR counting for differentiation of follicular thyroid tumours. Pathologica 1994;86:301-303
17. Cor A, Pajer Z: Measurement characteristics of stereological and histochemical methods in the diagnosis of thyroid tumours. Oncology 1994;51:426-429
18. Crissman JD, Drozdowicz S, Johnson C, Kini SR: Fine needle aspiration diagnosis of hyperplastic and neoplastic follicular nodules of the thyroid: A morphometric study. Analyt Quant Cytol Histol 1991;13:321-328
19. De Micco C, Vasko V, Garcia S, Zoro P, Denizot A, Henry JF: Fine-needle aspiration of thyroid follicular neoplasm: Diagnostic use of thyroid peroxidase immunocytochemistry with monoclonal antibody 47. Surgery 1994;116:1031-1035
20. De Santis M, Sciarretta F, Sudano L, Perrone Donnorso R: Morphometric evaluation of histological sections of the thyroid gland in benign and malignant follicular lesions. Diagn Cytopathol 1987;3:60-67
21. Dominguez-Malagon H, Delgado-Chavez R, Torres-Najera M, Gould E, Albores-Saavedra J: Oxyphil and squamous variants of medullary thyroid carcinoma. Cancer 1989;63: 1183-1188
22. Droese M, Mentgen-Nothum V, Eins S, Klar R. Morphometrische Dignitätsbeurteilung follikulärer Schilddrüsentumoren im Feinnadelpunktat (abstr). 1981;65:384
23. Duskova J: Nuclear size and character of the nucleolar organizer in benign and malignant follicular tumors of the thyroid gland (in Czech). Cesk Patol 1992;28:201-206
24. el-Naggar AK, Batsakis JG, Luna MA, Hickey RC: Hürthle cell tumors of the thyroid. A flow cytometric DNA analysis. Arch Otolaryngol Head Neck Surg 1988;114:520-521
25. Ferrer-Roca O, Ballester-Guardia E, Martin-Rodriguez JA: Morphometric, densitometric and flow cytometric criteria for the automated classification of thyroid lesions. Analyt Quant Cytol Histol 1990;12:48-55
26. Finsterer H: Onkocytäres Zellbild im Schilddrüsenpunktat: Beurteilung und Differentialdiagnose. Verh Dtsch Ges Pathol 1984;68:494
27. Flint A, Davenport RD, Lloyd RV, Beckwith AL, Thompson NW: Cytophotometric measurements of Hürthle cell tumors of the thyroid gland: Correlation with pathologic features and clinical behavior. Cancer 1988;61:110-113
28. Franssila KO, Ackerman LV, Brown CL, Hedinger CE: Follicular carcinoma. Semin Diagn Pathol 1985;2:101-122
29. Frost JK: The Cell in Health and Disease. Second edition. In Monographs in Clinical Cytology. Edited by GL Wied. Second volume. Basel, Karger; 1986, pp 126-144
30. Galera-Davidson H, Bibbo M, Bartels PH, Dytch HE, Puls JH, Wied GL: Correlation between automated DNA ploidy measurements of Hürthle-cell tumors and their histopathologic and clinical features. Analyt Quant Cytol Histol 1986;8: 158-167
31. Gonzalez JL, Wang HH, Ducatman BS: Fine-needle aspiration of Hürthle cell lesions: A cytomorphologic approach to diagnosis. Am J Clin Pathol 1993;100:231-235
32. Grant CS: Operative and postoperative management of the patient with follicular and Hürthle cell carcinoma. Do they differ? Surg Clin North Am 1995;75:395-403
33. Hedinger C, Williams ED, Sobin LH: Histological Typing of Thyroid Tumors. International Histological Classification of Tumors, No.11. Second edition. Berlin, Springer-Verlag, 1988, pp 5-8
34. Herrera MF, Hay ID, Wu PS, Goellner JR, Ryan JJ, Ebersold JR, Bergstralh EJ, Grant CS: Hürthle cell (oxyphilic) papillary thyroid carcinoma: A variant with more aggressive biologic behavior. World J Surg 1992;16:669-674
35. Hill JH, Werkhaven JA, DeMay RM: Hürthle cell variant of papillary carcinoma of the thyroid gland. Otolaryngol Head Neck Surg 1988;98:338-341
36. Jayaram G: Problems in the interpretation of Hürthle cell populations in fine needle aspirates from the thyroid (lett). Acta Cytol 1983;27:84-85
37. Johannessen JV, Sobrinho-Simoes M, Finseth I, Pilstrom L: Ultrastructural morphometry of thyroid neoplasms. Am J Clin Pathol 1983;79:166-171
38. Karmakar T, Dey P: Role of AGNOR in diagnosis of thyroid follicular neoplasms on fine-needle aspiration smears. Diagn Cytopathol 1995;12:148-151
39. Kaur A, Jayaram G: Thyroid tumors: Cytomorphology of Hürthle cell tumors, including an uncommon papillary variant. Diagn Cytopathol 1993;9:135-137
40. Kini SR: Thyroid: Guides to Clinical Aspiration Biopsy. Second edition. New York, Igaku-Shoin, 1996, pp 105-127
41. Kini SR, Miller JM, Hamburger JI: Cytopathology of Hürthle cell lesions of the thyroid gland by fine needle aspiration. Acta Cytol 1981;25:647-652
42. Kriete A, Romen W, Schaffer R, Harms H, Haucke M, Ger-lach B, Aus M, ter Meulen V: Computer analysis of chromatin arrangement and nuclear texture in follicular thyroid tumors. Histochemistry 1983;78:227-230
43. Kriete A, Schaffer R, Harms H, Aus HM: On-line transmission electron microscopic image analysis of chromatin texture for differentiation of thyroid gland tumors. Analyt Quant Cytol Histol 1987;9:268-272
44. Krisch K, Jakesz R, Erd W, Klement MB, Feigl W, Sinzinger H, Laczkovics A: Punktatzytologie benigner und maligner Schilddrüsenveränderungen. MMW Munch Med Wochen-schr 1976;118:1383-1386
45. La Rosa GL, Cavallari V, Giuffrida D, Scimone S, La Porta GA, Maiorana MC, Maiorana A, Belfiore A: The morphomet-ric analysis of cell nuclei from fine needle aspirates of thyroid follicular lesions does not improve the diagnostic accuracy of traditional cytologic examination. J Endocrinol Invest 1990;13:701-707
46. Lang W, Atay Z, Georgii A: Die cytologische Unterscheidung follikulärer Tumoren in der Schilddrüse. Virchows Arch 1978;378:199-211
47. Lang W, Georgii A, Atay Z: Differentialdiagnose zwischen atypischem Adenom und follikulärem Carcinom der Schilddrüse. Verh Dtsch Ges Pathol 1977;61:275-279
48. Liautaud-Roger F, Dufer J, Delisle MJ, Coninx P: Thyroid neoplasms. Can we do any better with quantitative cytology? Analyt Quant Cytol Histol 1992;14:373-378
49. LiVolsi VA: Current concepts in follicular tumors of the thyroid. Monogr Pathol 1993;35:118-137
50. Luck JB, Mumaw VR, Frable WJ: Fine needle aspiration biopsy of the thyroid: Differential diagnosis by videoplan image analysis. Acta Cytol 1982;26:793-796
51. McLeod MK, Thompson NW, Hudson JL, Gaglio JA, Lloyd RV, Harness JK, Nishiyama R, Cheung PS: Flow cytometric measurements of nuclear DNA and ploidy analysis in Hürthle cell neoplasms of the thyroid. Arch Surg 1988; 123:849-854
52. Montironi R, Alberti R, Sisti S, Braccischi A, Scarpelli M, Mariuzzi GM: Discrimination between follicular adenoma and follicular carcinoma of the thyroid: Preoperative validity of cytometry on aspiration smears. Appl Pathol 1989;7:367-374
53. Montironi R, Braccischi A, Scarpelli M, Matera G, Alberti R: Value of quantitative nucleolar features in the preoperative cytological diagnosis of follicular neoplasias of the thyroid. J Clin Pathol 1991;44:509-514
54. Montironi R, Braccischi A, Scarpelli M, Sisti S, Alberti R: Well differentiated follicular neoplasms of the thyroid: Reproducibility and validity of a 'decision tree' classification based on nucleolar and karyometric features. Cytopathology 1992;3:209-222
55. Montironi R, Braccischi A, Scarpelli M, Sisti S, Matera G, Mariuzzi GM, Alberti R, Collan Y: The number of nucleoli in benign and malignant thyroid lesions: A useful diagnostic sign in cytological preparations. Cytopathology 1990;1: 153-161
56. Montironi R, Santinelli A, Scarpelli M, Braccischi A, Pisani E, Alberti R: Cytologic diagnosis of non-oxyphil follicular neoplasias of the thyroid: Multivariate classification procedure based on quantitative nucleolar features. Pathol Res Pract 1992;188:504-509
57. Montironi R, Scarpelli M, Braccischi A, Magi Galluzzi C, Diamanti L, Alberti R: Quantitative analysis of nucleolar margination in diagnostic cytopathology. Virchows Arch Pathol Anat Histol 1991;419:505-512
58. Nafe R, Choritz H: Introduction of a neuronal network as a tool for diagnostic analysis and classification based on experimental pathologic data. Exp Toxicol Pathol 1992;44: 17-24
59. Nafe R, Fritsch RS, Soudah B, Hamann A, Choritz H: Histo-morphometry in paraffin sections of thyroid tumors. Pathol Res Pract 1992;188:1042-1048
60. Pilch H, Back W, Winter J: DNA-Zytophotometrie oxyphiler Schilddrüsentumoren. Zentralbl Pathol 1993;139:433-436
61. Ranchod M: Thyroid gland. Pathol: State Art Rev 1996;3: 389-403
62. Ravinsky E, Safneck JR: Differentiation of Hashimoto's thyroiditis from thyroid neoplasms in fine needle aspirates. Acta Cytol 1988;32:854-861
63. Ruschoff J, Prasser C, Cortez T, Hohne HM, Hohenberger W, Hofstadter F: Diagnostic value of AGNOR staining in follicular cell neoplasms of the thyroid: Comparison of evaluation methods and nucleolar features. Am J Surg Pathol 1993;17: 1281-1288
64. Ryan JJ, Hay ID, Grant CS, Rainwater LM, Farrow GM, Goellner JR: Flow cytometric DNA measurements in benign and malignant Hürthle cell tumors of the thyroid. World J Surg 1988;12:482-487
65. Salmon I, Gasperin P, Pasteels JL, Heimann R, Kiss R: Relationship between histopathologic typing and morphonu-clear assessments of 238 thyroid lesions: Digital cell image analysis performed on Feulgen-stained nuclei from formalin-fixed, paraffin-embedded materials. Am J Clin Pathol 1992;97:776-786
66. Schaffer R, Kriete A, Harms H, Aus HM. Zur Klassifikation von Schilddrüsentumoren mittels computergestützter Kernbildanalyse (abstr). Verh Dtsch Ges Pathol 1985;69:473
67. Schark C, Fulton N, Yashiro T, Stanislav G, Jacoby R, Straus FH 2d, Dytch H, Bibbo M, Kaplan EL: The value of measurement of ras oncogenes and nuclear DNA analysis in the diagnosis of Hürthle cell tumors of the thyroid. World J Surg 1992;16:745-751
68. Schuh D, Steidl R, Mende T, Schneider H, Reske W: Ergebnisse der automatischen Mikroskopbildanalyse von Schild-drüsen-feinnadelbiopsien. Zentralbl Allg Pathol 1984;129: 35-41
69. Schuh D, Steidl R, Voss K: Unterscheidung von follikulären Adenomen und Karzinomen in der Schilddrüsenfeinnadelbiopsie. Zentralbl Allg Pathol 1980;124:557-560
70. Schurmann G, Mattfeldt T, Feichter G, Koretz K, Moller P, Buhr H: Stereology, flow cytometry, and immunohisto-chemistry of follicular neoplasms of the thyroid gland. Hum Pathol 1991;22:179-184
71. Shem-Tov Y, Straus M, Talmi YP, Rath-Wolfsom L, Zohar Y, Gal R: Nucleolar organizer regions in follicular tumors of the thyroid. Head Neck 1994;16:420-423
72. Slowinska-Klencka D, Klencki M, Sporny S, Lewinski A: Size of thyrocyte nuclei in aspirates from follicular adenomas: Correlation with patients ages. Acta Cytol 1996;40:414-416
73. Soares P, Sobrinho-Simoes M: Recent advances in cytometry, cytogenetics and molecular genetics of thyroid tumours and tumour-like lesions. Pathol Res Pract 1995;191:304-317
74. Stephenson BM, Wheeler MH, Clark OH: The role of total thyroidectomy in the management of differentiated thyroid cancer. Curr Opin Gen Surg 1994;53-59
75. Szot W, Zaczek M, Nowak K, Kedra D, Chap Z, Szybinski Z: Morphometric measurements of the nuclear area in proliferative thyroid lesions. Patol Pol 1994;45:29-33
76. Tallini G, Carcangiu ML, Rosai J: Oncocytic neoplasms of the thyroid gland. Acta Pathol Jpn 1992;42:305-315
77. Tasca C, Stefaneanu L: Cytology and cytophotometry in thyroid diseases. Acta Histochem 1977;60:261-272
78. Vodanovic S, Crepinko I, Smoje J: Morphologic diagnosis of Hurthle cell tumors of the thyroid gland. Acta Cytol 1993; 37:317-322
79. Wright RG, Castles H: Variability of thyroid cell nuclear size with Romanowsky stains. Acta Cytol 1987;31:526-527
80. Wright RG, Castles H, Mortimer RH: Morphometric analysis of thyroid cell aspirates. J Clin Pathol 1987;40:443-445
81. Zbieranowski I, Murray D: The study of endocrine tumors by flow and image cytometry. Endocr Pathol 1992;3:63-82
82. Zeppa P, Ferrara G, Chiacchio R, Fulciniti F, Troncone G, Nappi O, Vetrani A, Palombini L: L-thyroxine effects on thyreocytes and Hurthle cells in nodular hyperplastic goiter on fine needle aspiration samples. Morphometric evaluation. Analyt Quant Cytol Histol 1994;16:189-195