β-adrenoceptors in the hearts of diabetic-hypertensive rats: Radioligand binding and functional experiments

Blood Pressure

Volumn 6, Issue 1, 1997, Pages 44-51

  Beenen, Odile H M ^a   Batink, Harry D ^a   Pfaffendorf, Martin ^a   Van Zwieten, Pieter A ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

adenylyl cyclase; diabetes mellitus; forskolin; G proteins; hypertension; adrenoceptor agonists; adrenoceptors

Indexed keywords

4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; DOBUTAMINE; FORSKOLIN; SALBUTAMOL; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CARDIOTONIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; ESSENTIAL HYPERTENSION; INOTROPISM; ISOLATED HEART; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY; SPONTANEOUSLY HYPERTENSIVE RAT; ANIMAL; BLOOD PRESSURE; BODY WEIGHT; COMPARATIVE STUDY; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; HEART; HEART CONTRACTION; HEART MUSCLE; HEART RATE; HISTOLOGY; HYPERTENSION; METABOLISM; ORGAN SIZE; PATHOPHYSIOLOGY; PHYSIOLOGY; RADIOASSAY; ULTRASTRUCTURE; WISTAR KYOTO RAT;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; BODY WEIGHT; CARDIOTONIC AGENTS; DIABETES MELLITUS, EXPERIMENTAL; DOBUTAMINE; FORSKOLIN; HEART; HEART RATE; HYPERTENSION; MYOCARDIAL CONTRACTION; MYOCARDIUM; ORGAN SIZE; RADIOLIGAND ASSAY; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTORS, ADRENERGIC, BETA;

EID: 0030614353     PISSN: 08037051     EISSN: None     Source Type: Journal    
DOI: 10.3109/08037059709086445     Document Type: Article

References (34)

1. Atkins FL, Dowell RT, Love S. β-Adrenergic receptors, adenylate cyclase activity, and cardiac dysfunction in the diabetic rat. J Cardiovasc Pharmacol 1985; 7: 66-70.
2. Heyliger CE, Pierce GN, Singal PK, Beamish RE, Dhalla NS. Cardiac alpha- and beta-adrenergic receptor alterations in diabetic cardiomyopathy. Basic Res Cardiol 1982; 77: 610-8.
3. Ramanadham S, Tenner TE, Jr.. Alterations in the myocardial Beta-adrenoceptor system of streptozotocin-diabetic rats. Eur J Pharmacol 1987; 136: 377-89.
4. Ganguly PK, Beamish RE, Dhalla KS, Innes IR, Dhalla NS. Norepinephrine storage, distribution, and release in diabetic cardiomyopathy. Am J Physiol 1987; 252: E734-E739.
5. Wartofsky L, Burman KD. Alterations in thyroid function in patients with systemic illness: The "euthyroid sick syndrome". Endocr Rev 1982; 3: 164-217.
6. Bilezikian JP, Loeb JN. The influence of hyperthyroidism and hypothyroidism on a- and b-adrenergic receptor systems and adrenergic responsiveness. Endocr Rev 1983; 4: 378-88.
7. Yu Z, McNeill JH. Altered inotropic responses in diabetic cardiomyopathy and hypertensive-diabetic cardiomyopathy. J Pharmacol Exp Meth 1991; 257: 64-71.
8. Vadlamudi RV, McNeill JH. Effect of experimental diabetes on isolated rat heart responsiveness to isoproterenol. Can J Physiol Pharmacol 1984; 62: 124-31.
9. Masuyama Y, Fukuda K. Adrenoceptors in experimental hypertension. Clin Exp Hypertens A 1989; 11 Suppl 1: 31-42.
10. Böhm M, Beuckelmann D, Diet F, Feiler G, Lohse MJ, Erdmann E. Properties of cardiac alpha- and beta-adrenoceptors in spontaneously hypertensive rats. Naunyn-Schmiedeberg's Arch Pharmacol 1988; 338: 383-91.
11. Michel MC, Kanczik R, Khamssi M, et al. Alpha- and beta-adrenoceptors in hypertension. I. Cardiac and renal alpha 1-, beta 1-, and beta 2-adrenoceptors in rat models of acquired hypertension. J Cardiovasc Pharmacol 1989; 13: 421-31.
12. Murakami T, Katada T, Yasuda H. Reduction in the activity of the stimulatory guanine nucleotide-binding protein in the myocardium of spontaneously hypertensive rats. J Molec Cell Cardiol 1987; 19: 199-208.
13. Factor SM, Bhan R, Minase T, Wolinsky H, Sonnenblick EH. Hypertensive-diabetic cardiomyopathy in the rat: an experimental model of human disease. Am J Pathol 1981; 102: 219-28.
14. Epstein M, Sowers JR. Diabetes mellitus and hypertension. Hypertension 1992; 19: 403-18.
15. Rodrigues B, McNeill JH. Cardiac function in spontaneously hypertensive diabetic rats. Am J Physiol 1986; 251: H571-H580.
16. 125Iodo] cyanopindolol, a new ligand for beta-adrenoceptors: identification and quantitation of subclasses of beta-adrenoceptors in guinea pig. Naunyn-Schmiedeberg's Arch Pharmacol 1981; 317: 277-85.
17. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analyt Biochem 1976; 72: 248-54.
18. Scatchard G. The attraction of proteins for small molecules and ions. Ann NY Acad Sci 1949; 51: 660-72.
19. Yamamoto J. Blood pressure and metabolic effects of streptozotocin in wistar kyoto and spontaneously hypertensive rats. Clin Exp Hypertens A 1988; 10: 1065-83.
20. Susie D, Mandal AK, Jovovic DJ, Radujkovic G, Kentera D. Streptozotocin-induced diabetes mellitus lowers blood pressure in spontaneously hypertensive rat. Clin Exp Hypertens A 1990; 12: 1021-35.
21. Tahiliani AG, McNeill JH. Diabetes-induced abnormalities in the myocardium. Life Sci 1986; 38: 959-74.
22. Lopaschuk GD, Tahiliani AG, Vadlamudi RV, Katz S, McNeill JH. Cardiac sarcoplasmic reticulum function in insulin- or carnitine-treated diabetic rats. Am J Physiol 1983; 245: H969-H976.
23. Dillmann WH. Diabetes and thyroid-hormone-induced changes in cardiac function and their molecular basis. [Review]. A Rev Med 1989; 40: 373-94.
24. Kashiwagi A, Nishio Y, Saeki Y, Kida Y, Kodama M, Shigeta Y. Plasma membrane-specific deficiency in cardiac b-adrenereic receptor in streptozotocin-diabetic rats. Am J Physiol 1989; 257: E127-E132.
25. Pfaffendorf M, Batink HD, Kam KL, Pijl AJ, Mathy M-J, van Zwieten PA. Characteristics of b-adrenoceptors in cardiac tissue from spontaneously hypertensive rats with streptozotocin-induced diabetes mellitus. Br J Pharmacol 1994; 112: 40P.
26. Michel MC, Wang XL, Schlicker E, Göthert M, Beckeringh JJ, Brodde OE. Increased beta 2-adrenoreceptor density in heart, kidney and lung of spontaneously hypertensive rats. J Auton Pharmacol 1987; 7: 41-51.
27. Ikawa H, Suzuki A. Effects of aging and drugs on myocardial beta-adrenergic receptors in M-SHRSP and SHRSP. Clin Exp Hypertens A 1991; 13: 1091-106.
28. Yamada S, Ishima T, Tomita T, Hayashi M, Okada T, Hayashi E. Alterations in cardiac alpha and beta adrenoceptors during the development of spontaneous hypertension. J Pharmacol Exp Ther 1984; 228: 454-60.
29. Limas CJ, Limas C. Altered intracellular adrenoceptor distribution in myocardium of spontaneously hypertensive rats. Am J Physiol 1987; 253: H904-H908.
30. Matsumori Y, Ohyanagi M, Kawamoto H, Shibata R, Iwasaki T. Intracellular distribution of cardiac beta-adrenoceptors in SHR and WKY. Jpn Circ J 1989; 53: 113-20.
31. Böhm M, Gierschik P, Knorr A, Larisch K, Weismann K, Erdmann E. Role of altered G-protein expression in the regulation of myocardial adenylate cyclase activity and force of contraction in spontaneous hypertensive cardiomyopathy in rats. J Hypertens 1992; 10: 1115-28
32. Michel MC, Brodde OE, Insel PA. Are cardiac G-proteins altered in rat models of hypertension? J Hypertens 1993; 11: 355-63.
33. Mertens MJF, Mathy M-J, Pfaffendorf M, van Zwieten PA. Depressed inotropic response to beta-adrenoceptor agonists in The presence of advanced cardiac hypertrophy in hearts from rats with induced aortic stenosis and from spontaneously hypertensive rats. J Hypertens 1992; 10: 1361-8.
34. Asano M, Masuzawa K, Matsuda T, Asano T. Decreased responsiveness to beta-adrenoceptor agonists in arterial strips from spontaneously hypertensive rats is not associated with alterations in beta-adrenoceptors. J Hypertens 1991; 9: 607-13.