Neurosteroid modulation of [3H]flunitrazepam binding in the medulla: An autoradiographic study

Brain Research

Volumn 768, Issue 1-2, 1997, Pages 301-309

  Garrett, Kennon M ^a   Barron, Kirk W ^a   Briscoe, Richard J ^a   Heesch, Cheryl M ^b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

3 Hydroxy 5 pregnan 20 one; Allopregnanolone; Benzodiazepine; Female; GABA(A) receptor; Medulla; Neurosteroid; Rat

Indexed keywords

FLUNITRAZEPAM; NEUROSTEROID; 4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; DIAGNOSTIC AGENT; ELTANOLONE; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; AUTORADIOGRAPHY; BINDING SITE; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; LIGAND BINDING; MEDULLA OBLONGATA; NEUROMODULATION; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; STEROID METABOLISM; ANIMAL; FEMALE; METABOLISM; PHYSIOLOGY; RADIOASSAY; SPRAGUE DAWLEY RAT;

ANIMALS; AUTORADIOGRAPHY; FEMALE; FLUNITRAZEPAM; GABA MODULATORS; MEDULLA OBLONGATA; PREGNANOLONE; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; TRITIUM;

EID: 0030613693     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00665-3     Document Type: Article

References (50)

1. 4 subunits mRNAs in the rat brain. Mol. Brain Res. 12:1992;293-314.
2. Belelli D., Bolger M.B., Gee K.W. Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one. Eur. J. Pharmacol. 166:1989;325-329.
3. Bonham A.C. Neurotransmitters in the CNS control of breathing. Respir. Physiol. 101:1995;219-230.
4. A receptor function in long- and short-sleep mice. Brain Res. Bull. 29:1992;57-68.
5. 3H]flunitrazepam binding throughout the rat brain: an autoradiographic study. J. Pharmacol. Exp. Ther. 263:1992;1401-1414.
6. Chen S.-W., Rodriguez L., Davies M.F., Loew G.H. The hyperphagic effect of 3α-hydroxylated pregnan steroids in male rats. Pharmacol. Biochem. Behav. 53:1996;777-782.
7. Cohen W.R., Galen L.H., Vega-Rich M., Young J.B. Cardiac sympathetic activity during rat pregnancy. Metabolism. 37:1988;771-777.
8. Crawley J.N., Glowa J.R., Majewska D.M., Paul S.M. Anxiolytic activity of an endogenous adrenal steroid. Brain Res. 398:1986;382-385.
9. A receptor complex. J. Pharmacol. Exp. Ther. 265:1993;1374-1379.
10. Finn D.A., Gee K.W. The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid. J. Pharmacol. Exp. Ther. 271:1994;164-170.
11. A receptor regulation: chronic treatment with pregnanolone uncouples allosteric interactions between steroid and the benzodiazepine recognition sites. Mol. Pharmacol. 44:1993;191-197.
12. A-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J. Comp. Neurol. 359:1995;154-194.
13. A receptor complex, attenuate pain sensitivity in rats. Brain Res. 643:1994;194-203.
14. Gatti P.J., DaSilva A.M., Gillis R.A. Cardiorespiratory effects produced by injecting drugs that affect GABA receptors into nuclei associated with the ventral surface of the medulla. Neuropharmacology. 26:1987;423-431.
15. Gee K.W., Bolger M.B., Brinton R.E., Coirini H., McEwen B.S. Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action. J. Pharmacol. Exp. Ther. 246:1988;803-812.
16. A receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation. Mol. Pharmacol. 40:1991;995-999.
17. P.C. Guyenet, Role of the ventral medulla oblongata in blood pressure regulation, in: A.D. Lowey, K.M. Spyer (Eds.), Central Regulation of Autonomic Function, Oxford University Press, New York, 1990, pp. 145-167.
18. Haddingham K.L., Wingrove P.B., Wafford K.A., Kemp J.A., Palmer K.J., Wilson A.W., Sikela J.M., Ragan C.I., Whiting P.J. Role of the β subunit in determining the pharmacology of human γ-aminobutyric acid type A receptors. Mol. Pharmacol. 44:1993;1211-1218.
19. Harrison N.L., Simmonds M.A. Modulation of the GABA receptor complex by a steroid anaesthetic. Brain Res. 323:1984;287-292.
20. Heesch C.M., Rogers R.C. Effects of pregnancy and progesterone metabolites on regulation of sympathetic outflow. Clin. Exp. Pharmacol. Physiol. 22:1995;136-142.
21. Holzbauer M. Physiological variations in the ovarian production of 5α-pregnane derivatives with sedative properties in the rat. J. Steroid Biochem. 6:1975;1307-1310.
22. Jussofie A. Brain region-specific effects of neuroactive steroids on the affinity and density of the GABA-binding site. Biol. Chem. Hoppe-Seyler. 374:1993;265-270.
23. Kihara M., Kubo T. Cardiovascular effects of GABA system activating drugs injected into the caudal ventrolateral medulla of the rat. Arch. Int. Pharmacodyn. Ther. 295:1988;67-79.
24. Laiprasert J.D., Rogers R.C., Heesch C.M. Effects of acute administration of 3α-OH-dihydroprogesterone (DHP) on neurons in the rostral ventral lateral medulla (RVLM) in virgin female rats. FASEB J. 10:1996;A58.
25. A receptors to neurosteroids. J. Neurochem. 57:1991;1818-1821.
26. A receptors channels. Annu. Rev. Neurosci. 17:1994;569-602.
27. A receptor. Mechanisms of action and physiological significance. Prog. Neurobiol. 38:1992;379-395.
28. Majewska M.D., Harrison N.L., Schwartz R.D., Barker J.L., Paul S.M. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science. 232:1986;1004-1007.
29. S.A. Masilamani, C.M. Heesch, Effects of pregnancy and progesterone metabolites on arterial baroreflex in conscious rats, Am. J. Physiol. 272 (1997) R924-R934.
30. Mayo W., Dellu F., Robel P., Cherkaoui J., Moal M.L., Baulieu E.-E., Simon H. Infusion of neurosteroids into the nucleus basalis magnocellularis affect cognitive processes in the rat. Brain Res. 60:1993;324-328.
31. Melchior C.L., Ritzmann R.F. Dehydroepiandrosterone enhances the hypnotic and hypothermic effects of ethanol and pentobarbital. Pharmacol. Biochem. Behav. 43:1992;223-227.
32. Melchior C.L., Ritzmann R.F. Dehydroepiandrosterone is an anxiolytic in mice on the plus maze. Pharmacol. Biochem. Behav. 47:1994;437-441.
33. Morrow L.A., Pace J.R., Purdy R.H., Paul S.M. Characterization of steroid interactions with γ-aminobutyric acid receptor-gated chloride channels: evidence for multiple recognition sites. Mol. Pharmacol. 37:1990;263-270.
34. A receptor binding in human brain by neuroactive steroids: species and brain regional differences. Synapse. 19:1995;77-87.
35. Paul S.M., Purdy R.H. Neuroactive steroids. FASEB J. 6:1992;2311-2322.
36. A receptors in the solitary nucleus? FASEB J. 9:1995;A293.
37. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, 2nd ed., Academic Press, Orlando, FL, 1986.
38. A receptor by depressant barbiturates and pregnane steroids. Br. J. Pharmacol. 94:1988;1257-1269.
39. A receptors. Neuropharmacology. 32:1993;59-63.
40. A receptor subunit composition? Recept. Channels. 1:1993;135-142.
41. Purdy R.H., Moore P.H., Rao P.N., Hagino N., Yamaguchi T., Schmidt P., Rubinow D.R., Morrow A.L., Paul S.M. Radioimmunoassay of 3α-hydroxy-5α-pregnan-20-one in rat and human plasma. Steroids. 55:1990;290-296.
42. A receptors in rat brain. J. Pharmacol. Exp. Ther. 262:1992;801-808.
43. A receptor on the response to a neurosteroid. Eur. J. Pharmacol. 206:1991;77-80.
44. A receptor subtypes. Pharmacol. Rev. 47:1995;181-234.
45. A.F. Sved, GABA-mediated neural transmission in mechanisms of cardiovascular control by the NTS, in: I.R.A. Barraco (Ed.), Nucleus of the Solitary Tract, CRC Press, Ann Arbor, MI, 1994, pp. 245-253.
46. L.W. Swanson, Rat Maps: Structure of the Rat Brain, Elsevier, New York, 1992.
47. Turner D.M., Ransom R.W., Yang J.S.-J., Olsen R.W. Steroid anesthetics and naturally occurring analogs modulate the γ-aminobutyric acid receptor complex at a site distinct from barbiturates. J. Pharmacol. Exp. Ther. 248:1989;960-966.
48. A receptor complex by steroids in slices of rat cuneate nucleus. Br. J. Pharmacol. 96:1989;409-417.
49. Wieland S., Lan N.C., Mirasedeghi S., Gee K.W. Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one. Brain Res. 565:1991;263-268.
50. A receptors in rat brainstem and rostral brain regions. Neuroscience. 49:1992;973-989.