Enhancement by O6-benzyl-N2-acetylguanosine of N'-[2-chloroethyl]-N [2-(methylsulphonyl)ethyl]-N'-nitrosourea therapeutic index on nude mice bearing resistant human melanoma

British Journal of Cancer

Volumn 76, Issue 9, 1997, Pages 1157-1162

  Debiton, E ^a   Cussac Buchdhal, C ^a   Mounetou, E ^a   Rapp, M ^a   Dupuy, J M ^a   Maurizis, J C ^a   Veyre, A ^a   Madelmont, J C ^a  

^a INSERM   (France)

Author keywords

Melanoma; N' 2 chloroethyl N 2 (methylsulphonyl)ethyl N' nitrosourea; O6 alkylguanine DNA alkyltransferase; O6 benzyl N2 acetylguanosine; Therapeutic index

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; ACETIC ACID DERIVATIVE; BENZYL DERIVATIVE; CHLOROETHANE; CYSTEMUSTINE; GUANOSINE DERIVATIVE; METHYL GROUP; NITROSOUREA DERIVATIVE; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; GUANOSINE; N' (2 CHLOROETHYL) N (2 (METHYLSULFONYL)ETHYL) N' NITROSOUREA; N'-(2-CHLOROETHYL)-N-(2-(METHYLSULFONYL)ETHYL)-N'-NITROSOUREA; O(6) BENZYL N ACETYLGUANOSINE; O(6)-BENZYL-N-ACETYLGUANOSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER TRANSPLANTATION; CYTOSTASIS; DRUG EFFICACY; DRUG SOLUBILITY; FEMALE; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LD 50; MELANOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOLUBILITY; TUMOR CELL; ANIMAL; CELL CULTURE; COMPARATIVE STUDY; MELANOMA; NUDE MOUSE; TIME;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; FEMALE; GUANOSINE; HUMANS; INJECTIONS, INTRAVENOUS; MELANOMA; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NITROSOUREA COMPOUNDS; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0030613630     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.527     Document Type: Article

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