Effects of the angiotensin AT1 receptor antagonist GR138950 on haemodynamic function in dogs

Journal of Autonomic Pharmacology

Volumn 17, Issue 1, 1997, Pages 1-11

  Hunt, A A E ^a   Hilditch, A ^a   Drew, G M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN RECEPTOR; SAPRISARTAN; ANGIOTENSIN II; ANTIHYPERTENSIVE AGENT; BENZOFURAN DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DOG; DOSE RESPONSE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEMODYNAMICS; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; VASCULAR RESISTANCE; ANIMAL; BLOOD FLOW; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; FEMORAL ARTERY; HEART CONTRACTION; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; MESENTERIC ARTERY; MUSCLE RELAXATION; PHYSIOLOGY; RENAL ARTERY; VASCULAR SMOOTH MUSCLE;

ADMINISTRATION, ORAL; ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; BENZOFURANS; BLOOD PRESSURE; CARDIAC OUTPUT; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMORAL ARTERY; HEART RATE; HEMODYNAMIC PROCESSES; INJECTIONS, INTRAVENOUS; MALE; MESENTERIC ARTERIES; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; MYOCARDIAL CONTRACTION; RECEPTORS, ANGIOTENSIN; REGIONAL BLOOD FLOW; RENAL ARTERY; STROKE VOLUME; VASCULAR RESISTANCE;

EID: 0030613517     PISSN: 01441795     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2680.1997.00406.x     Document Type: Article

References (19)

1. ANDREEN, M. (1974). Computerised measurement of cardiac output by thermodilution: Methodological aspects. Acta Anaesth. Scand., 18, 297-305.
2. BATIN, P., GARDINER, S.M., COMPTON, A.M. & BENNETT, T. (1991). Differential regional haemodynamic effects of the non-peptide angiotensin II antagonist, DuP 753, in water-replete and water-deprived Brattleboro rats. Life Sci., 48, 733-739.
3. BATIN, P., GARDINER, S.M., COMPTON, A.M., KEMP, P.A. & BENNETT, T. (1991). Cardiac haemodynamic effects of the non-peptide, angiotensin II-receptor antagonist, DuP 753, in conscious Long Evans and Brattleboro rats. Br. J. Pharmacol., 103, 1585-1591.
4. 1 receptor antagonist. Eur. J. Pharmacol., 280, 195-203.
5. COHN, P.F., LIEDTKE, A.J., SERUR, J., SONNENBLICK, E.H. & URSCHEL, C.W. (1972). Maximal rate of pressure fall (peak negative dP/dt) during ventricular relaxation. Cardiovasc. Res., 6, 263-267.
6. ERMAKOV, S. & HOYT, J.W. (1992). Pulmonary artery catheterization. Critical Care Clinics, 8, 773-806.
7. GARDNER, P.E. (1993). Pulmonary artery pressure monitoring. AACN Clinical Issues, 4, 98-119.
8. GOTTLIEB, S.S., DICKSTEIN, K., FLECK, E. et al. (1993). Hemodynamic and neurohumeral effects of the angiotensin II antagonist losartan in patients with congestive heart failure. Circulation, 88, 1602-1609.
9. GUYTON, A.C. & GREGANTI, F.P. (1956). A physiological reference point for measuring circulatory pressures in the dog - particularly venous pressure. Am. J. Physiol., 185, 137-141.
10. 1 receptor antagonist. Br. J. Pharmacol., 108(suppl.), 239P.
11. 1 receptor antagonist. J. Pharmacol. Exp. Ther., 272, 750-757.
12. JUDD, D.B., DOWLE, M.D., MIDDLEMlSS, D. et al. (1994). Bromobenzofuran-based non-peptide antagonists of angiotensin II: GR138950, a potent antihypertensive agent with high bioavailability. J. Med. Chem., 37, 3108-3120.
13. MAUGHAN, W.L., SUNAGAWA, K., BURKHOFF, D. & SAGAWA, K. (1984). Effect of arterial impedance changes on the end-systolic pressure-volume relation. Circ. Res., 54, 595-602.
14. O'BRIEN, D.J., CHAPMAN, W.H., RUDD, F.V. & MCROBERTS, J.N. (1971). Carotid artery loop method of blood pressure measurement in the dog. J. Appl. Physiol., 30, 161-163.
15. RAYA, T.E., FONKEN, S.J., LEE, R.W. et al., (1991). Hemodynamic effects of direct angiotensin II blockade compared to converting enzyme inhibition in rat model of heart failure. Am. J. Hypertens., 4(suppl), 334S-340S.
16. RICHARD, V., BERDEAUX, A. & GIUDICELLI, J-F. (1993). Systemic and coronary effects of the angiotensin II receptor antagonist EXP3174 in dogs. J. CARDIOVASC. PHARMACOL., 22, 52-57.
17. SUGA, H., SAGAWA, K. & SHOUKAS, A. (1973). Load independence of the instantaneous pressure-volume ratio of the canine left ventricle and effects of epinephrine and heart rate on the ratio. Circ. Res., 32, 314-322.
18. WEISFELDT, M.L., SCULLY, H.E., FREDERIKSEN, JM. et al. (1974). Hemodynamic determinants of maximum negative dP/dt and periods of diastole. Am. J. Physiol., 227, 613-621.
19. WONG, P.C., HART, S.D., DUNCIA, J.V. & TIMMERMANS, P.B.M.W.M. (1991). Nonpeptide angiotensin II receptor antagonists. Studies with DuP 753 and EXP3174 in dogs. Eur. J. Pharmacol., 202, 323-330.