Alpha-I adrenoceptor subtypes (High, Low) in human benign prostatic hypertrophy tissue according to the affinities for prazosin

Prostate

Volumn 31, Issue 4, 1997, Pages 216-222

  Takeda, Masayuki ^a   Hatano, Akihiko ^a   Komeyama, Takeshi ^a   Koizumi, Takako ^a   Mizusawa, Takaki ^a   Kanai, Toshio ^a   Tomita, Yoshihiko ^a   Maruyama, Keiko ^b   Nagatomo, Takafumi ^b  

^a NIIGATA UNIVERSITY   (Japan)

^b Department of Pharmacology   (Japan)

Author keywords

(1H) adrenoceptor; (1L) adrenoceptor; 1 adrenoceptor subtype; Antiandrogen, 1 blocker; Human benign prostatic hypertrophy

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; PHENOXYBENZAMINE; PRAZOSIN; RECEPTOR SUBTYPE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT;

ALPHA ADRENERGIC RECEPTOR BLOCKING; ARTICLE; DRUG RECEPTOR BINDING; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; RECEPTOR AFFINITY; SCATCHARD PLOT; AGED; CLASSIFICATION; METABOLISM;

ADRENERGIC ALPHA-ANTAGONISTS; AGED; HUMANS; MALE; PRAZOSIN; PROSTATIC HYPERPLASIA; RECEPTORS, ADRENERGIC, ALPHA-1;

EID: 0030612806     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0045(19970601)31:4<216::AID-PROS2>3.0.CO;2-I     Document Type: Article

References (28)

1. Caine M, Raz S, Ziegler M: Adrenergic and cholinergic receptors in the human prostate, prostatic capsule and bladder neck. Br J Urol 27:1-1, 1975.
2. Kunisawa Y, Kawabe K, Niijima T, Honda K, Takenaka T: A pharmacological study of alpha adrenergic receptor subtypes in smooth muscle of human urinary bladder base and prostatic urethra. J Urol 134:396-398, 1985.
3. Hedlund H, Andersson KE, Larsson B: Alpha-adrenoceptors and muscarinic receptors in the isolated human prostate. J Urol 134:1291-1298, 1985.
4. Lepor H: Non-operative management of human prostatic hyperplasia. J Urol 141:1283-1289, 1989.
5. 1-adrenoceptors: Consensus update. Mol Pharmacol 47:267-270, 1996.
6. Lepor H, Tang R, Meretyk S, Shapiro E: Alpha 1 adrencoceptor subtypes in the human prostate. J Urol 149:640-642, 1993.
7. Lepor H, Tang R, Shapiro E: The alpha-adrenoceptor subtype mediating the tension of human prostatic smooth muscle. Prostate 22:301-307, 1993.
8. Lepor H, Tang R, Meretyk S, Shapiro E: Binding and functional properties of alpha1 adrenoceptors in different regions of the human prostate. J Urol 150:253-256, 1993.
9. Yamada S, Suzuki M, Tanaka C, Mori R, Kimura R, Inagaki O, Honda K, Asano M, Takenada T, Kawabe K: Comparative study on α1-adrenoceptor antagonist binding in human prostate and aorta. Clin Exp Pharmacol Physiol 21:405-411, 1994.
10. Yamada S, Tanaka C, Kimura R, Kawabe K: Alpha1-adrenoceptors in human prostate: Characterization and binding characteristics of alpha1-antagonists. Life Sci 54:1845-1854, 1994.
11. Forray C, Bard JA, Wetzel JM, Chiu G, Shapiro E, Tang R, Lepor H, Hartig PR, Weinshank RL, Branchek TA, Gluchowski C: The α1-adrenergic receptor the mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human α1c subtype. Mol Pharmacol 45:703-708, 1994.
12. Guh J-H, Chueh S-C, Ko F-N, Teng C-M: Characterization of α1-adrenoceptor subtypes in tension response of human prostate to electrical field stimulation. Br J Pharmacol 115:142-146, 1995.
13. Marshall I, Burt RP, Chapple CR: Noradrenaline contraction of human prostate mediated by α1A-(α1c-) adrenoceptor subtypes. Br J Pharmacol 115:781-786, 1995.
14. Crank T, Kost T, Goetz A, Hazum S, Roberson KM, Haizlip J, Godinot N, Robertson CN, Saussy D: The α1c-adrenoceptor in human prostate: Cloning, functional expression, and localization to specific prostatic cell types. Br J Pharmacol 115:1475-1485, 1995.
15. Muramatsu I, Ohmura T, Kigoshi S, Hashimoto S, Ohshita M: Pharmacological subclassification of α1-adrenoceptors in vascular smooth muscle. Br J Pharamacol 99:197-201, 1990.
16. Maruyama K, Tsuchihashi H, Baba S, Mano, F, Nagatomo T: Alpha 1-adrenoceptor subtypes in bovine prostate. J Pharm Pharmacol 44:727-730, 1992.
17. Kanimoto Y, Okada K: Anti-androgen therapy of benign prostatic hyperplasia: Review of the agents evaluation of the clinical trials. Acta Urol Jpn 37:1423-1428, 1991.
18. Lowry OH, Rosebruogh NJ, Farr AL, Randal RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275, 1951.
19. Munson PJ, Roland D: LIGAND: A versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107:220-239, 1980.
20. Kawabe K, Moriyama N, Hamada K, Ishima T: Density and localization of alpha 1-adrenoceptors in hypertrophied prostate. J Urol 143:592-595, 1990.
21. 3H]Bunazosin, a novel selective radioligand of alpha1 adrenoceptors in human prostates. J Urol 146: 877-880, 1991.
22. Flavahan NA, Vanhoutte PM: α1-Adrenoceptor subclassification in vascular smooth muscle. Trends Pharmacol Sci 7:347-349, 1986.
23. Coats J, Jahan U, Weetman DF: The existence of a new subtype of α1-adrenoceptor on the rat anococygeus is revealed by Sgd 101/75 and phenoxybenzamine. Br J Pharmacol 75:549-552, 1986.
24. Ohmura T, Oshita M, Kigoshi S, Muramatsu I: Identification of α1-adrenoceptor subtypes in the rat vas deferens: Bindng and functional studies. Br J Pharmacol 107:697-704, 1992.
25. Lepor H, Knapp-Maloney G, Sunshine H: A dose titration study evaluationg terazosin, once-a-day alphal-blocker for the treatment of symptomatic BPH. J Urol 144:1393-1398, 1990.
26. Ford APDW, Arredondo NF, Blue DR, Bonhaus DW, Jasper J, Kava MS, Lesnick J, Pfister JR, Shieh IA, Vimont RL, Williams TJ, McNeal JE, Stamey TA, Clarke DE: RS-17053 (N-[2-(2-Cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl1H- indole-3-ethanomine hydrochloride), a selective α1A-adrenoceptor antagonist, displays low affinity for functional aladrenoceptors in human prostate: Implications for adrenoceptor classification. Mol Pharmacol 49:209-215, 1996.
27. Sallès J, Badia A: Modulation of ±1-adrenoceptors and functional consequences in the bisected rat vas deferens following chronic inhibition of neuronal noradrenaline uptake. Br J Pharmacol 108:678-683, 1993.
28. Morita T: Sex hormones and the functions of the lower urinary tract smooth muscles. [In Japanese]. Mebio 9:84-88, 1993.