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Volumn 81, Issue 2, 1997, Pages 65-73

Binding of 3H-metronidazole in olfactory, respiratory and alimentary epithelia in rats

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; METRONIDAZOLE; CYTOCHROME P450; ENZYME INHIBITOR; GLUTATHIONE; METYRAPONE; NITROGEN; PROTEIN; TRITIUM;

EID: 0030612785     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1997.tb00033.x     Document Type: Article
Times cited : (5)

References (36)
  • 1
    • 0021365187 scopus 로고
    • Metabolism dependent binding of the chlorinated insecticide DDT and its metabolite DDD to microsomal proteins and lipids
    • Baker, M.T. & R.A. Van Dyke: Metabolism dependent binding of the chlorinated insecticide DDT and its metabolite DDD to microsomal proteins and lipids. Biochem. Pharmacol. 1984, 33, 255-260.
    • (1984) Biochem. Pharmacol. , vol.33 , pp. 255-260
    • Baker, M.T.1    Van Dyke, R.A.2
  • 2
    • 0023892122 scopus 로고
    • Sites for xenobiotic activation and detoxication within the respiratory tract: Implications for chemically induced toxicity
    • Baron, J., J.P. Burke, F.P. Guengerich, W.B. Jakoby & J.M. Voigt: Sites for xenobiotic activation and detoxication within the respiratory tract: Implications for chemically induced toxicity. Toxicol Appl. Pharmacol. 1988, 93, 493-505.
    • (1988) Toxicol Appl. Pharmacol. , vol.93 , pp. 493-505
    • Baron, J.1    Burke, J.P.2    Guengerich, F.P.3    Jakoby, W.B.4    Voigt, J.M.5
  • 3
    • 0018862085 scopus 로고
    • Metabolites from the reduction of metronidazole by xanthine oxidase
    • Chrystal, E.J.T., R.L. Koch & P. Goldman: Metabolites from the reduction of metronidazole by xanthine oxidase. Mol. Pharmacol. 1980, 18, 105-111.
    • (1980) Mol. Pharmacol. , vol.18 , pp. 105-111
    • Chrystal, E.J.T.1    Koch, R.L.2    Goldman, P.3
  • 4
    • 0024324985 scopus 로고
    • Autoradiographic study of tritium-labelled misonidazole in the mouse
    • Cobb, L.M., F.R.C. Path & J. Nolan: Autoradiographic study of tritium-labelled misonidazole in the mouse. Int. J. Radiat. Oncol. Biol. Phys. 1989, 16, 953-956.
    • (1989) Int. J. Radiat. Oncol. Biol. Phys. , vol.16 , pp. 953-956
    • Cobb, L.M.1    Path, F.R.C.2    Nolan, J.3
  • 5
    • 0025248444 scopus 로고
    • NAD(P)H nitroblue tetrazolium reductase levels in apparently normoxic tissues: A histochemical study correlating enzyme activity with binding of radio-labelled misonidazole
    • Cobb, L.M.. T. Hacker & J. Nolan: NAD(P)H nitroblue tetrazolium reductase levels in apparently normoxic tissues: a histochemical study correlating enzyme activity with binding of radio-labelled misonidazole. Brit. J. Cancer 1990, 61, 524-529.
    • (1990) Brit. J. Cancer , vol.61 , pp. 524-529
    • Cobb, L.M.1    Hacker, T.2    Nolan, J.3
  • 6
    • 0029858319 scopus 로고    scopus 로고
    • Disposition of metronidazole in hens (Gallus gallus) and quails (Coturnix coturnix japonica): Pharmacokinetics and whole-body autoradiography
    • Cybulski, W., P. Larsson, H. Tjälve, H. Kowlska-Pylka, M. Sylla & S. Semeniuk:Disposition of metronidazole in hens (Gallus gallus) and quails (Coturnix coturnix japonica): pharmacokinetics and whole-body autoradiography. J. Vet. Pharmacol. Therap. 1996, 19, 352-358.
    • (1996) J. Vet. Pharmacol. Therap. , vol.19 , pp. 352-358
    • Cybulski, W.1    Larsson, P.2    Tjälve, H.3    Kowlska-Pylka, H.4    Sylla, M.5    Semeniuk, S.6
  • 7
    • 0025838093 scopus 로고
    • Nasal cavity enzymes involved in xenobiotic metabolism: Effects on the toxicity of inhalants
    • Dahl, A.R., & W.M. Hadley. Nasal cavity enzymes involved in xenobiotic metabolism: Effects on the toxicity of inhalants. CRC Crit. Rev. Toxicol. 1991, 21, 345-372.
    • (1991) CRC Crit. Rev. Toxicol. , vol.21 , pp. 345-372
    • Dahl, A.R.1    Hadley, W.M.2
  • 8
    • 13844323009 scopus 로고
    • Genotoxicity and carcinogenicity of metronidazole
    • Dobiás, L., M. Cerná, P. Rössner & R. Srám: Genotoxicity and carcinogenicity of metronidazole. Mut. Res. 1994, 317, 177-194.
    • (1994) Mut. Res. , vol.317 , pp. 177-194
    • Dobiás, L.1    Cerná, M.2    Rössner, P.3    Srám, R.4
  • 9
    • 0022577790 scopus 로고
    • Reduction of nitroimidazoles in vitro and DNA damage
    • Edwards, D.I.: Reduction of nitroimidazoles in vitro and DNA damage. Biochem. Pharmacol. 1986, 35, 53-58.
    • (1986) Biochem. Pharmacol. , vol.35 , pp. 53-58
    • Edwards, D.I.1
  • 10
    • 0024993419 scopus 로고
    • Review article: Metronidazole and the anaerobic gut flora
    • Elliott, T.S.J. & J.W. Stone: Review article: Metronidazole and the anaerobic gut flora. Aliment. Pharmacol. Therap. 1990, 4, 227-238.
    • (1990) Aliment. Pharmacol. Therap. , vol.4 , pp. 227-238
    • Elliott, T.S.J.1    Stone, J.W.2
  • 12
    • 0023892307 scopus 로고
    • The metabolic activation of nitroheterocyclic therapeutic agents
    • Kedderis, G.L., & G.T. Miwa: The metabolic activation of nitroheterocyclic therapeutic agents. Drug Metab. Rev. 1988, 19, 33-62.
    • (1988) Drug Metab. Rev. , vol.19 , pp. 33-62
    • Kedderis, G.L.1    Miwa, G.T.2
  • 13
    • 0024337831 scopus 로고
    • Covalent interaction of 5-nitroimidazoles with DNA and protein in vitro: Mechanism of reductive activation
    • Kedderis, G.L., L.S. Argenbright & G.T. Miwa: Covalent interaction of 5-nitroimidazoles with DNA and protein in vitro: Mechanism of reductive activation. Chem. Res. Toxicol. 1989, 2, 146-149.
    • (1989) Chem. Res. Toxicol. , vol.2 , pp. 146-149
    • Kedderis, G.L.1    Argenbright, L.S.2    Miwa, G.T.3
  • 14
    • 0027619954 scopus 로고
    • Interaction between chemicals and melanin
    • Larsson, B.S.: Interaction between chemicals and melanin. Pigment Cell Res. 1993, 6, 127-133.
    • (1993) Pigment Cell Res. , vol.6 , pp. 127-133
    • Larsson, B.S.1
  • 16
    • 0026610239 scopus 로고
    • Binding of aflatoxin B, metabolites in extrahepatic tissues in fetal and infant mice and in adult mice with depleted glutathione levels
    • Larsson, P. & H. Tjälve: Binding of aflatoxin B, metabolites in extrahepatic tissues in fetal and infant mice and in adult mice with depleted glutathione levels. Cancer Res. 1992, 52, 1267-1277.
    • (1992) Cancer Res. , vol.52 , pp. 1267-1277
    • Larsson, P.1    Tjälve, H.2
  • 17
    • 0028924740 scopus 로고
    • Extrahepatic bioactivation of aflatoxin B1 in fetal, infant and adult rats
    • Larsson, P. & H. Tjälve: Extrahepatic bioactivation of aflatoxin B1 in fetal, infant and adult rats. Chem.-Biol. Interact. 1995, 94, 1-19.
    • (1995) Chem.-Biol. Interact. , vol.94 , pp. 1-19
    • Larsson, P.1    Tjälve, H.2
  • 18
    • 0028179819 scopus 로고
    • Hepatic and extrahepatic bioactivation and GSH-conjugation of aflatoxin B1 in sheep
    • Larsson, P., L. Busk & H. Tjälve: Hepatic and extrahepatic bioactivation and GSH-conjugation of aflatoxin B1 in sheep. Carcinogenesis 1994, 15, 947-955.
    • (1994) Carcinogenesis , vol.15 , pp. 947-955
    • Larsson, P.1    Busk, L.2    Tjälve, H.3
  • 19
    • 0025246208 scopus 로고
    • Metronidazole and antipyrine as probes for the study of foreign compound metabolism
    • Loft, S.: Metronidazole and antipyrine as probes for the study of foreign compound metabolism. Pharmacology & Toxicology. 1990, 66, Suppl. VI, 1-31.
    • (1990) Pharmacology & Toxicology , vol.66 , Issue.6 SUPPL. , pp. 1-31
    • Loft, S.1
  • 21
    • 0025011226 scopus 로고
    • Comparison of the sensitivity of human and rat hepatocytes to the genotoxic effects of metronidazole
    • Martelli, A., A. Allavena, L. Robbiano, F. Mattioli & G. Brambilla: Comparison of the sensitivity of human and rat hepatocytes to the genotoxic effects of metronidazole. Pharmacology & Toxicology. 1990, 66, 329-334.
    • (1990) Pharmacology & Toxicology , vol.66 , pp. 329-334
    • Martelli, A.1    Allavena, A.2    Robbiano, L.3    Mattioli, F.4    Brambilla, G.5
  • 23
    • 0022615157 scopus 로고
    • Reductive activation of nitroimidazoles in anaerobic microorganisms
    • Müller, M.: Reductive activation of nitroimidazoles in anaerobic microorganisms. Biochem. Pharmacol. 1986, 35, 37-41.
    • (1986) Biochem. Pharmacol. , vol.35 , pp. 37-41
    • Müller, M.1
  • 24
    • 0027502038 scopus 로고
    • Drug metabolism in the nasal cavity: Relevance to toxicology
    • Reed, C.J.: Drug metabolism in the nasal cavity: Relevance to toxicology. Drug Metab. Rev. 1993, 25, 173-205.
    • (1993) Drug Metab. Rev. , vol.25 , pp. 173-205
    • Reed, C.J.1
  • 25
    • 0020575137 scopus 로고
    • Toxicologic evaluation of metronidazole with particular reference to carcinogenic, mutagenic, and teratogenic potential
    • January
    • Roe, F.J.C.: Toxicologic evaluation of metronidazole with particular reference to carcinogenic, mutagenic, and teratogenic potential. Surgery 1983, January, 158-163.
    • (1983) Surgery , pp. 158-163
    • Roe, F.J.C.1
  • 26
    • 0016830694 scopus 로고
    • Mutagenicity of metronidazole: Activation by mammalian liver microsomes
    • Rosenkranz, H.S. & W.T. Speck: Mutagenicity of metronidazole: Activation by mammalian liver microsomes. Biochem. Biophys. Res. Comm. 1975, 66, 520-525.
    • (1975) Biochem. Biophys. Res. Comm. , vol.66 , pp. 520-525
    • Rosenkranz, H.S.1    Speck, W.T.2
  • 27
    • 0015304363 scopus 로고
    • Induction of lung tumors and malignant lymphomas in mice by metronidazole
    • Rustia, M. & P. Shubik: Induction of lung tumors and malignant lymphomas in mice by metronidazole. J. Nat. Cancer Inst. 1972, 48, 721-729.
    • (1972) J. Nat. Cancer Inst. , vol.48 , pp. 721-729
    • Rustia, M.1    Shubik, P.2
  • 28
    • 0018736370 scopus 로고
    • Experimental induction of hepatomas. mammary tumors, and other tumors with metronidazole in non-inbred Sas:MRC(WI)BR rats
    • Rustia, M. & P. Shubik: Experimental induction of hepatomas. mammary tumors, and other tumors with metronidazole in non-inbred Sas:MRC(WI)BR rats. J. Nat. Cancer Inst. 1979, 63, 863-868.
    • (1979) J. Nat. Cancer Inst. , vol.63 , pp. 863-868
    • Rustia, M.1    Shubik, P.2
  • 29
    • 0023736805 scopus 로고
    • Mucosal biotransformation
    • Schwenk, M.: Mucosal biotransformation. Toxicol. Pathol. 1988, 16, 138-146.
    • (1988) Toxicol. Pathol. , vol.16 , pp. 138-146
    • Schwenk, M.1
  • 30
  • 31
    • 0019835546 scopus 로고
    • Inhibitors of cytochrome P-450s and their mechanism of action
    • Testa, B. & P. Jenner: Inhibitors of cytochrome P-450s and their mechanism of action. Drug Metab. Rev. 1981, 12, 1-117.
    • (1981) Drug Metab. Rev. , vol.12 , pp. 1-117
    • Testa, B.1    Jenner, P.2
  • 32
    • 0025825611 scopus 로고
    • The tissue distribution and the tissue specificity of bioactivation of some tobacco-specific and some other N-nitrosamines
    • Tjälve, H.: The tissue distribution and the tissue specificity of bioactivation of some tobacco-specific and some other N-nitrosamines. CRC Critical Rev. in Toxicol. 1991, 21, 265-294.
    • (1991) CRC Critical Rev. in Toxicol. , vol.21 , pp. 265-294
    • Tjälve, H.1
  • 33
    • 0026610843 scopus 로고
    • Bioactivation of aflatoxin B1 in the bovine olfactory mucosa: DNA binding, mutagenicity and induction of sister chromatid exchanges
    • Tjälve, H., P. Larsson, C. Andersson & L. Busk: Bioactivation of aflatoxin B1 in the bovine olfactory mucosa: DNA binding, mutagenicity and induction of sister chromatid exchanges. Carcinogenesis 1992, 13, 1345-1350.
    • (1992) Carcinogenesis , vol.13 , pp. 1345-1350
    • Tjälve, H.1    Larsson, P.2    Andersson, C.3    Busk, L.4
  • 34


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