Inhibition of M3 muscarinic acetylcholine receptor-mediated Ca2+ influx and intracellular Ca2+ mobilization in neuroblastoma cells by the Ca2+/calmodulin-dependent protein kinase inhibitor 1-[N,O-bis(5- isoquinolinesulfonyl)-N-methyl-L-trosyl]-4-phenylpiperazine (KN-62)

Biochemical Pharmacology

Volumn 53, Issue 8, 1997, Pages 1107-1114

  Puhl, Henry L ^a   Raman, Padma S ^a   Williams, Carol L ^a   Aronstam, Robert S ^a  

^a GUTHRIE RESEARCH INSTITUTE   (United States)

Author keywords

Ca2+ channels; Ca2+ calmodulin dependent protein kinase; KN 62; muscarinic acetylcholine receptor; SK N SH human neuroblastoma

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; CALCIUM CHANNEL; CALCIUM ION; CARBACHOL; CHOLINERGIC RECEPTOR; DIVALENT CATION; EGTAZIC ACID; FURA 2; MANGANESE; MUSCARINIC M3 RECEPTOR; NICKEL; PROTEIN KINASE (CALCIUM,CALMODULIN); 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 4 DIPHENYLACETOXY 1,1 DIMETHYLPIPERIDINIUM; 4-DIPHENYLACETOXY-1,1-DIMETHYLPIPERIDINIUM; CALCIUM; DRUG DERIVATIVE; ENZYME INHIBITOR; MUSCARINIC RECEPTOR; PIPERIDINE DERIVATIVE;

ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CONTROLLED STUDY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; NEUROBLASTOMA;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CARBACHOL; ENZYME INHIBITORS; HUMANS; NEUROBLASTOMA; PIPERIDINES; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0030612777     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00089-0     Document Type: Article

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