The development of alkylphosphocholines as signal transduction inhibitors: Experimental and clinical challlenges [1]

Journal of Cancer Research and Clinical Oncology

Volumn 123, Issue 5, 1997, Pages 286-287

  Hilgard, P ^a   Pohl, J ^a   Engel, J ^a  

^a ASTA MEDICA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLPHOSPHOCHOLINE DERIVATIVE; ANTINEOPLASTIC AGENT; DIMETHYLBENZ[A]ANTHRACENE; UNCLASSIFIED DRUG; ZINDOXIFENE; NEW DRUG; PHOSPHOLIPASE C; PHOSPHORYLCHOLINE; PROTEIN KINASE C;

ANIMAL TISSUE; BREAST CARCINOMA; CONTROLLED STUDY; DRUG DEVELOPMENT; LETTER; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT;

ANIMALS; ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, INVESTIGATIONAL; PHOSPHOLIPASE C; PHOSPHORYLCHOLINE; PROTEIN KINASE C; RATS; SIGNAL TRANSDUCTION;

EID: 0030612702     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01208640     Document Type: Letter

References (10)

1. B. Drugs Today 30 [Suppl B]
2. Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240: 889-895
3. Gibbs JB. Cliff A (1994) Pharmaceutical research in molecular oncology. Cell 79: 193-198
4. Grunicke H (1995) Signal transduction mechanisms in cancer. Landes. Austin
5. Hilgard P, Stekar J, Wuttke W, Elliger M, Holtei W (1988) Comparative pharmacology of zindoxifene and tamoxifen. Prog Cancer Res Ther 35: 369-373
6. Hilgard P, Stekar J, Voegeli R, Harleman JH (1992) Experimental therapeutic studies with miltefosine in rats and mice. In: Eibl H, Hilgard P, Unger C (eds) Alkylphosphocholines: new drugs in cancer therapy. Prog Exp Tumor Res 34: 98-115
7. Michna H, Schneider MR, Nishino Y, El Etrebi MF (1989) The antitumor mechanism of progesterone antagonists is a receptor mediated antiproliferative effect by induction of terminal cell death. J Steroid Biochem 34: 447-453
8. Minana MD, Felipo V, Grisolia S (1990) Inhibition of protein kinase C induces differentiation in Neuro-2a-cells. Proc Natl Acad Sci USA 87: 4335-4339
9. Reissmann T, Engel J, Kutscher B, Bernd M, Hilgard P, Peukert M, Szelenyi I, Reichert S, Gonzalez-Barcena D, Nieschlag E, ComaruSchally AM, Schally AV (1994) Cetrorelix. Drugs Future 19: 228-237
10. Linger C (1996) Current concepts of treatment in medical oncology: new anticancer drugs. J Cancer Res Clin Oncol 122: 189-198