Involvement of the REV3 gene in the methylated base-excision repair system. Co-operation of two DNA polymerases, δ and rev3p, in the repair of MMS-induced lesions in the DNA of saccharomyces cerevisiae

Current Genetics

Volumn 31, Issue 4, 1997, Pages 292-301

  Halas, Agnieszka ^a   Baranowska, Hanna ^a   Policińska, Zofia ^a   Jachymczyk, Witold J ^a  

^a INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

Author keywords

Base excision repair; DNA polymerase ; DNA polymerase Rev3; S. cerevisiae

Indexed keywords

DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE GAMMA; FUNGAL PROTEIN; GLYCOPROTEIN; MESYLIC ACID METHYL ESTER; POL4 PROTEIN, S CEREVISIAE; REV3 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SINGLE STRANDED DNA;

ARTICLE; DNA METHYLATION; DNA REPAIR; ENZYME ACTIVE SITE; EXCISION REPAIR; GENE; MUTAGENESIS; MUTANT; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TEMPERATURE; DNA DAMAGE; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; MUTATION;

DNA DAMAGE; DNA METHYLATION; DNA POLYMERASE II; DNA POLYMERASE III; DNA REPAIR; DNA, SINGLE-STRANDED; DNA-DIRECTED DNA POLYMERASE; FUNGAL PROTEINS; GLYCOPROTEINS; METHYL METHANESULFONATE; MUTATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TEMPERATURE;

EID: 0030612690     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002940050208     Document Type: Article

References (36)

1. Aguilera A, Klein HL (1988) Genetic control of intrachromosomal recombination in Saccharomyces cerevisiae. I. Isolation and genetic characterisation of hyper-recombination mutations. Genetics 119:779-790
2. Araki H, Ropp PA, Johnson AL, Johnson LH, Morrison A, Sugino A (1992) DNA polymerase II, the probable homologue of mammalian DNA polymerase ε, replicates chromosomal DNA in the yeast Saccharomyces cerevisiae. EMBO J 11:733-740
3. Blank A. Kim B, Loeb L (1994) DNA polymerase δ is required for base-excision repair of DNA methylation damage in Saccharomyces cerevisiae Proc Natl Acad Sci USA 91:9047-9051
4. Budd ME, Campbell JL (1987) Temperature-sensitive mutants of yeast DNA polymerase I. Proc Nat Acad Sci USA 84:2838-2842
5. Budd ME, Campbell JL (1993) DNA polymerase δ and ε are required for chromosomal replication in Saccharomyces cerevisiae. J Biol Chem 264:6557-6565
6. Budd ME, Campbell JL (1995 a) DNA polymerases required for the repair of UV-induced damage in Saccharomyces cerevisiae. Mol Cell Biol 15:2173-2179
7. Budd ME, Campbell JL (1995 b) Purification and enzymatic and functional characterisation of the DNA polymerase β-like enzyme POL4, expressed during yeast meiosis. Methods Enzymol 262:108-130
8. Budd ME, Sitney KC, Campbell JL (1989 a) DNA polymerase III, a second essential DNA polymerase is encoded by the Saccharomyces cerevisiae CDC2 gene. Cell 56:599-605
9. Budd ME, Wittrup KD, Bailey JE, Campbell JL (1989b) DNA polymerase I is required of DNA replication but not for repair in Saccharomyces cerevisiae. Mol Cell Biol 9:365-376
10. Campbell JL, Newlon CS (1991) Chromosomal DNA replication. In: Broach JR, Pringle JR, Jones ER (eds) The molecular and cellular biology of the yeast Saccharomyces: genome dynamics, protein synthesis and energetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp 41-146
11. Cassier-Chauvat C, Moustacchi E (1988) Allelism between pso1-1 and rev3-1 mutants and between pso2-1 and sum1 mutants in Saccharomyces cerevisiae Curr Genet 13:37-40
12. Dianov G, Price A, Lindahl T (1992) Generation of single-nucleotide repair paths following excision of uracil residues from DNA. Mol Cell Biol 12:1605-1612
13. Friedberg EC (1985) DNA repair. W.H. Freeman, New York
14. Friefelder D (1970) Molecular weights of coli phages and phage DNA. J Mol Biol 54:567-577
15. Gibbs PEM, Lawrence CW (1995) Novel mutagenic properties of abasic sites in Saccharomyces cerevisiae. J Mol Biol 251:229-236
16. Kato T, Shinoura Y (1977) Isolation and characterization of mutants of Escherichia coli deficient in the induction of mutations by UV-light. Mol Gen Genet 156:121-131
17. Lawrence CW, Cristensen RB (1979) Ultraviolet-induced reversion of cyc1 alleles in radiation-sensitive strains of yeast. III. rev3 mutant strains. Genetics 92:397-408
18. Lee SH, Pan ZQ, Kwong AD, Burgers PMJ, Hurvitz J (1991) Synthesis of DNA by DNA polymerase ε in vitro. J Biol Chem 266:22707-22717
19. Leem SH, Ropp PA, Sugino A (1994) The yeast Saccharomyces cerevisiae DNA polymerase IV - possible involvement in double-stand break DNA repair. Nucleic Acids Res 22:3011-3017
20. Matsumoto Y, Bogenhagen DF (1991) Repair of a synthetic abasic site involves concerted reactions of DNA synthesis followed by excision and ligation. Mol Cell Biol 11:4441-4447
21. Morrison A, Christensen RB, Alley J, Beck AK, Bernstine EG, Lemontt JF, Lawrence CW (1989) REV3, a Saccharomyces cererisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase. J. Bacteriol 171:5659-5667
22. Morrison A, Hiroyuki A, Clark AB, Hamatake RR, Sugino A (1990) A third essential DNA polymerase in Saccharomyces cerevisiae Cell 62:1143-1151
23. Nishida C, Reinhardt P, Linn S (1988) DNA repair synthesis in human fibroblasts requires DNA polymerase δ. J Biol Chem 263:501-510
24. Prasad R, Widen SG, Singhal RK, Watkins J, Prakash L, Wilson SH (1993) Yeast open reading frame YCR14C encodes a DNA β polymerase-like enzyme. Nucleic Acids Res 21:5301-5307
25. Sancar A, Sancar GB (1988) DNA repair enzymes. Annu Rev Biochem 57:29-67
26. Sherman F, Fink GR, Lawrence CW (1971) Methods in yeast genetics. Laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
27. Shimizu K, Santocantale P, Ropp A, Longhese MP, Plevani P, Lucchini G, Sugino A (1993) Purification and characterisation of a new DNA polymerase from the budding yeast Saccharomyces cerevisiae. J Biol Chem 268:27148-27153
28. Shivji MKK, Kenny K, Wood RD (1992) Proliferating cell nuclear antigen is required for DNA excision repair Cell 69:367-374
29. Singhal RK, Hinkle DC, Lawrence CW (1992) The REV3 gene of Saccharomyces cerevisiae is transcriptionally regulated more like a repair gene than one encoding a DNA polymerase. Mol Gen Genet 236:17-24
30. Singhal RK, Prasad R, Wilson SH (1995) DNA polymerase β conducts the gap-filling step in uracil-initiated base-excision repair in bovine testis nuclear extract. J Biol Chem 270:949-957
31. Sobol RW, Horton JK, Kühn R, Go H, Singhal RK, Prasad R, Rajewsky K, Wilson SH (1996) Requirement of mammalian DNA polymerase β in base-excision repair. Nature 397:183-186
32. Sugino A (1995) Yeast DNA polymerases and their role at the replication fork. Trends Biochem Sci 20:319-323
33. Suszek W, Baranowska H, Zuk J, Jachymczyk WJ (1993) DNA polymerase III is required for DNA repair in Saccharomyces cerevisiae. Curr Genet 24:200-204
34. Sweasy JB, Loeb LA (1992) Mammalian DNA polymerase β can substitute for DNA polymerase I during DNA replication in Escherichia coli. J Biol Chem 267:1407-1410
35. Wang Z, Wu X, Friedberg EC (1993) DNA repair synthesis during base excision repair in vitro is catalysed by DNA polymerase ε and is influenced by DNA polymerase α and δ in Saccharomyces cerevisiae. Mol Cell Biol 13:1051-1058
36. Zeng XR, Jiang Y, Zhang SJ, Hao H, Lee MYWT (1994) DNA polymerase δ is involved in the cellular response to UV damage in human cells. J Biol Chem 269:13768-13751