G(O2) and G(i3) proteins mediate the action of somatostatin on membrane Ca2+ and K+ currents in ovine pituitary somatotrophs

Clinical and Experimental Pharmacology and Physiology

Volumn 24, Issue 8, 1997, Pages 639-645

  Chen, Chen ^a,b  

^a MONASH MEDICAL CENTRE   (Australia)

^b HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Antibodies; Antisense oligonucleotides; Dialysis; Ion channels; Neutralization; Patch clamp

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (2 THIODIPHOSPHATE); GUANOSINE 5' O (3 THIOTRIPHOSPHATE); INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN; SOMATOSTATIN; CALCIUM CHANNEL; GUANOSINE TRIPHOSPHATE; POTASSIUM CHANNEL;

ADENOHYPOPHYSIS; ANIMAL CELL; CALCIUM CELL LEVEL; CALCIUM CURRENT; CELL CULTURE; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; GROWTH HORMONE RELEASE; IN VITRO STUDY; NONHUMAN; POTASSIUM CURRENT; SHEEP; ANIMAL; ARTICLE; DRUG EFFECT; HYPOPHYSIS; PHYSIOLOGY;

ANIMALS; CALCIUM CHANNELS; CELLS, CULTURED; GTP-BINDING PROTEINS; GUANOSINE TRIPHOSPHATE; PITUITARY GLAND; POTASSIUM CHANNELS; SHEEP; SOMATOSTATIN;

EID: 0030612680     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.1997.tb02105.x     Document Type: Conference Paper

References (22)

1. Chen C, Vincent JD, Clarke IJ. Ion channels and signal transduction pathways in the regulation of growth hormone secretion. Trends Endocrinol. Metab. 1994; 5: 227-33.
2. Chen C, Israel JM, Vincent JD. Electrophysiological responses to somatostatin of rat hypophysial cells in somatotroph-enriched primary cultures. J. Physiol. 1989; 408: 493-510.
3. Chen C, Zhang J, Vincent JD, Israel JM. Somatostatin increases voltage-dependent potassium currents in rat somatotrophs in primary culture. Am. J. Physiol. 1990; 250: C854-61.
4. Chen C, Zhang J, Vincent JD, Israel JM. Two types of voltage-dependent calcium current in rat somatotrophs are reduced by somatostatin. J. Physiol. 1990; 425: 29-42.
5. Nussinovitch I. Somatostatin inhibits two types of voltage-activated calcium currents in rat growth-hormone secreting cells. Brain Res. 1989; 504: 136-8.
6. Surprenant A, Shen KZ, North RA, Tatsumi H. Inhibition of calcium currents by noradrenaline, somatostatin and opioids in guinea-pig submucosal neurones. J. Physiol. 1990; 431: 585-608.
7. Ikeda SR, Schofield GG. Somatostatin cyclic octapeptide analogs which preferentially hind to SOMa receptors block a calcium current in rat superior cervical ganglion neurons. Neurosci. Lett. 1989; 96: 283-8.
8. Chen C. Electrical properties of rat somatotrophs in primary culture and their modification by somatostatin and growth hormone releasing factor. PhD thesis, University of Bordeaux, France. 1989.
9. Bell G, Reisine T. Molecular biology of somatostatin receptors. Trends Neurosci. 1993; 16: 34-8.
10. K protein in clonal rat anterior pituitary cell membranes. Mol. Endocrinol. 1987; 1: 283-9.
11. Kleuss C, Hescheler J, Ewel C, Rosenthal W, Schultz G, Wittig B. Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents. Nature 1991; 353: 43-8.
12. Chen C, Heyward P, Zhang J, Wu D, Clarke IJ. Voltage-dependent potassium currents in ovine somatotrophs and their function in growth hormone secretion. Neuroendocrinology 1994; 59: 1-9.
13. Baertschi AJ, Audigier Y, Lledo PM, Israel JM, Bockaert J, Vincent JD. Dialysis of lactotropes with antisense oligonucleotides assigns guanine nucleotide binding protein subtypes to their channel effectors. Mol. Endocrinol. 1992; 6: 2257-65.
14. o protein. J. Biol. Chem. 1990; 265: 11220-6.
15. Pusch M, Neher E. Rates of diffusional exchange between small cells and a measuring patch pipette. Pflügerx Arch. 1988; 411: 204-11.
16. Chen C, Clarke IJ. Go-2 protein mediates the reduction in Ca currents by somatostatin in cultured ovine somatotrophs. J. Physiol. 1996; 491: 21-9.
17. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 1981; 391: 85-100.
18. 2+ influx and growth hormone secretion in ovine somatotrophs by growth hormone-releasing factor. Am. J. Physiol. 1995; 268: E204-12.
19. Yasuda K, Rens-Domiano S, Breder C et al. Cloning of a novel somatostatin receptor. SSTR3, coupled to adenylyl cyclase. J. Biol. Chem. 1992; 267: 20422-8.
20. Reisine T, Kong H, Raynor K et al. Molecular biology of somatostatin receptors. In: Melmed S (ed.). Molecular and Clinical Advances in Pituitary Disorders. Endocrine Research and Education Inc., Los Angeles. 1993: 293-7.
21. Epelbaum J, Enjalbert A, Krantic S et al. Somatostatin receptors in pituitary somatotrophs. thyrotrophs, and lactotrophs: Pharmacological evidence for loose coupling to adenylate cyclase. Endocrinology 1987; 1: 2177-85.
22. 2+ current modulated by cGMP-dependent protein kinase. Nature 1994; 369: 336-9.