Characteristic of CD14 shedding from human monocytes. Evidence for the competition of soluble CD14 (sCD14) with CD14 receptors for lipopolysaccharide (LPS) binding

APMIS

Volumn 105, Issue 7, 1997, Pages 510-518

  Rokita, E ^a,b   Menzel, E J ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

CD14; Lipopolysaccharide; Monocytes; sCD14

Indexed keywords

CD14 ANTIGEN; CYCLOHEXIMIDE; DACTINOMYCIN; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; C REACTIVE PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MONOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; SEPSIS; BINDING COMPETITION; BURN; CELL ADHESION; DRUG EFFECT; IMMUNOLOGY; METABOLISM; PROTEIN BINDING; SOLUBILITY;

ANTIGENS, CD14; BINDING, COMPETITIVE; BURNS; C-REACTIVE PROTEIN; CELL ADHESION; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; MONOCYTES; PROTEIN BINDING; SOLUBILITY; TETRADECANOYLPHORBOL ACETATE;

EID: 0030612666     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1699-0463.1997.tb05048.x     Document Type: Article

References (33)

1. Bazil, V., Baudys, M., Hilgert, I., Stefanova, I., Low, M. G., Zbrozek, J. & Horejsi, V.: Structural relationship between the soluble and membrane-bound forms of human monocyte surface glycoprotein CD14. Mol. Immunol. 26: 657-662, 1989.
2. Bazil, V. & Strominger, J. L.: Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes. J. Immunol. 147: 1567-1574, 1991.
3. Borden, E. C. & Chin, P.: Interleukin-6: a cytokine with potential diagnostic and therapeutic roles. J. Lab. Clin. Med. 123: 824-829, 1994.
4. Boyum, A.: Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Invest. 21: 77-89, 1968.
5. Dentener, M. A., Bazil, V., Von Asmuth, E. J. U., Ceska, M. & Buurman, W. A.: Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-α, IL-6 and IL-8 release by human monocytes and alveolar macrophages. J. Immunol. 150: 2885-2891, 1993.
6. Frey, E. A., Miller, D. S., Jahr, T. G., Sundan, A., Bazil, V., Espevik, T., Finlay, B. B. & Wright, S. D.: Soluble CD14 participates in the response of cells to lipopolysaccharide. J. Exp. Med. 176: 1665-1671, 1992.
7. Grunwald, U., Krüger, C., Westermann, J., Lukowsky, A., Ehlers, M. & Schütt, C.: An enzyme-linked immunosorbent assay for the quantification of solubilized CD14 in biological fluids. J. Immunol. Methods. 155: 225-232, 1992.
8. Hack, C. E., Hart, M., Van Schijndel, R. J., Eerenberg, A. J., Nuijens, J. H., Thijs, L. G. & Aarden, L. A.: Interleukin-8 in sepsis: relation to shock and inflammatory mediators. Infect. Immun. 60: 2835-2842, 1992.
9. Hailman, E., Lichenstein, H. S., Wurfel, M. M., Miller, D. S., Johnson, D. A., Kelley, M., Busse, L. A., Zukowski, M. M. & Wright, S. D.: Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14. J. Exp. Med. 179: 269-277, 1994.
10. Hamilton, G., Hofbauer, S. & Hamilton, B.: Endotoxin, TNF-alpha, interleukin-6 and parameters of the cellular immune system in patients with intraabdominal sepsis. Scand. J. Infect. Dis. 24: 361-368, 1992.
11. Haziot, A., Chen, S., Ferrero, E., Low, M. G., Silber, R. & Goyert, S. M.: The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphoinositol linkage. J. Immunol. 141: 547-552, 1988.
12. Haziot, A., Rong, G. W., Bazil, V., Silver, J. & Goyert, S. M.: Recombinant soluble CD14 inhibits LPS-induced tumor necrosis factor-α production by cells in whole blood. J. Immunol. 152: 5868-5876, 1994.
13. Khemlani, L. S., Yang, Z. & Bochsler, P. N.: Identification and characterization of a bovine lipopolysaccharide-binding protein. J. Leukoc. Biol. 56: 784-791, 1994.
14. Kielian, T. L. & Blecha, F.: CD14 and other recognition molecules for lipopolysaccharide: a review. Immunopharmacology 29: 187-205, 1995.
15. Krüger, C., Schütt, C., Obertacke, U., Joka, T., Müller, F. E., Knöller, J., Köller, M., König, W. & Schönfeld, W.: Serum CD14 levels in polytraumatized and severely burned patients. Clin. Exp. Immunol. 85: 297-301, 1991.
16. Landmann, R., Fisscher, A. E. & Obrecht, J.-P.: Interferon-γ and interleukin-4 down-regulate soluble CD14 release in human monocytes and macrophages. J. Leukoc. Biol. 52: 323-330, 1992.
17. Landmann, R., Zimmerli, W., Sansano, S., Link, S., Hahn, A., Glauser, M. P. & Calandra, T.: Increased circulating CD14 is associated with high mortality in gram-negative septic shock. J. Infect. Dis. 171: 639-644, 1995.
18. Lee, J. D., Kato, K., Tobias, P. S., Kirkland, T. N. & Ulevitch, R. J.: Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein. J. Exp. Med. 175: 1697-1705, 1992.
19. Maliszewski, C. R., Ball, E. D., Graziano, R. F. & Fanger, M. W.: Isolation and characterization of My23, a myeloid cell-derived antigen reactive with the monoclonal antibody AML-23. J. Immunol. 135: 1929-1936, 1985.
20. Maliszewski, C. R. & Wright, S. D.: CD14 and immune response to lipopolysaccharide. Science 252: 1321-1322, 1991.
21. Morrison, D. C. & Rayan, J. L.: Endotoxins and disease mechanisms. Annu. Rev. Med. 38: 417-432, 1987.
22. Schluter, B., König, B., Bergmann, U., Müller, F. E. & König, W.: Interleukin-6 - a potential mediator of lethal sepsis after major thermal trauma: evidence for increased IL-6 production by peripheral blood mononuclear cells. J. Trauma. 31: 1663-1670, 1991.
23. Schumann, R. R., Leong, S. R., Flaggs, G. W., Gray, P. W., Wright, S. D., Mathison, J. C., Tobias, P. S. & Ulevitch, R. J.: Structure and function of lipopolysaccharide binding protein. Science 249: 1429-1431, 1990.
24. Schütt, C., Schilling, T., Grunwald, U., Schönfeld, W. & Krüger, C.: Endotoxin neutralizing capacity of soluble CD14. Res. Immunol. 143: 71-78, 1992.
25. Stone, R.: Search for sepsis drugs goes on despite past failures. Science 264: 365-367, 1994.
26. Tobias, P. S., Mathison, J., Mintz, D., Lee, J. D., Kravchenko, V., Kato, K., Pugin, J. & Ulevitch, R. J.: Participation of lipopolysaccharide-bind-ing protein in lipopolysaccharide-dependent macrophage activation. Am. J. Respir. Cell. Mol. Biol. 7: 239-245, 1992.
27. Tobias, P. S., Soldau, K., Gegner, J. A., Mintz, D. & Ulevitch, R. J.: Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide with soluble CD14. J. Biol. Chem. 270: 10482-10488, 1995.
28. Tobias, P. S. & Ulevitch, R. J.: Lipopolysaccharide binding protein and CD14 in LPS dependent macrophage activation. Immunobiology 187: 227-232, 1993.
29. Todd, R. F., Bhan, A. K., Kabawat, S. E. & Schlossman, S. F.: Human myelomonocytic differentiation antigens defined by monoclonal antibodies. In: Bernard A., Boumsell, L., Dausset, J., Milstein, C. & Schlossman, S. F. (Eds.): Leucocyte Typing, Human Leucocyte Differentiation Antigens Detected by Monoclonal Antibodies. New York, Springer-Verlag 1984, p 424-433.
30. Ulevitch, R. J. & Tobias, P. S.: Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu. Rev. Immunol. 13: 437-457, 1995.
31. Von Asmuth, E. J. U., Dentener, M. A., Bazil, B., Bouma, M. G., Leeuwenberg, J. F. M. & Buurman, W. A.: Anti-CD14 antibodies reduce responses of cultured human endothelial cells to endotoxin. Immunology 80: 78-83, 1993.
32. Wright, S. D., Ramos, R. A., Tobias, P. S., Ulevitch, R. J. & Mathison, J. C.: CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249: 1431-1433, 1990.
33. Ziegler-Heitbrock, H. W. L. & Ulevitch, R. J.: CD14: Cell surface receptor and differentiation marker. Immunol. Today 14: 121-125, 1993.