Inhibition of Ca2+ channel current by μ- and κ-opioid receptors coexpressed in Xenopus oocytes: Desensitization dependence on Ca2+ channel α1 subunits

British Journal of Pharmacology

Volumn 121, Issue 4, 1997, Pages 806-812

  Kaneko, Shuji ^a   Yada, Nobumichi ^a   Fukuda, Koichiro ^a   Kikuwaka, Masanobu ^a   Akaike, Akinori ^a   Satoh, Masamichi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Calcium channels; Heterologous desensitization; N type; Opioid receptors; Q type; Xenopus oocytes

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; CALCIUM CHANNEL; CALCIUM ION; FORSKOLIN; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; N (2 METHYLAMINOETHYL) 5 ISOQUINOLINESULFONAMIDE; OKADAIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHODIESTERASE INHIBITOR; PROTEIN SUBUNIT; RECEPTOR SUBTYPE; STAUROSPORINE; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ANTIHYPERTENSIVE AGENT; PROTEIN KINASE; PYRROLIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DESENSITIZATION; DOSE TIME EFFECT RELATION; FEMALE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; XENOPUS; ANIMAL; CELL MEMBRANE POTENTIAL; DRUG EFFECT; METABOLISM; TIME;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANIMALS; ANTIHYPERTENSIVE AGENTS; CALCIUM CHANNELS; MEMBRANE POTENTIALS; OOCYTES; PROTEIN KINASES; PYRROLIDINES; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; TIME FACTORS; XENOPUS;

EID: 0030612531     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701181     Document Type: Article

References (40)

1. ABDELHAMID, E.E. & TAKEMORI, A.E. (1991). Characteristics of μ and δ opioid binding sites in striatal slices of morphine-tolerant and -dependent mice. Eur. J. Pharmacol., 198, 157-163.
2. ARDEN, J.R., SEGREDO, V., WANG, Z., LAMEH, J. & SADÉE, W. (1995). Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged μ-opioid receptor expressed in HEK 293 cells. J. Neurochem., 65, 1636-1645.
3. ATTALI, B., SAYA, D. & VOGEL, Z. (1989). κ-Opiate agonists inhibit adenylate cyclase and produce heterologous desensitization in rat spinal cord. J. Neurochem., 52, 360-369.
4. BRODSKY, M., ELLIOTT, K., HYNANSKY, A. & INTURRISI, C.E. (1995). CNS levels of mu opioid receptor (MOR-1) mRNA during chronic treatment with morphine or naltrexone. Brain Res. Bull., 38, 135-141.
5. o in rat frontal cortex. FEBS Lett., 370, 135-140.
6. DUMAN, R.S., TALLMAN, J.F. & NESTLER, E.J. (1988). Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus. J. Pharmacol. Exp. Ther., 246, 1033-1039.
7. FUJITA, Y., MYNLIEFF, M., DIRKSEN, R.T., KIM, M.-S., NIIDOME, T., NAKAI, J., FRIEDRICH, T., IWABE, N., MIYATA, T., FURUICHI, T., FURUTAMA, D., MIKOSHIBA, K., MORI, Y. & BEAM, K.G. (1993). Primary structure and functional expression of the ω-conotoxin-sensitive N-type calcium channel from rabbit brain. Neuron, 10, 585-598.
8. 2+ channels expressed in Xenopus oocytes. Neurosci. Lett., 217, 13-16.
9. HARRIS, G.C. & WILLIAMS, J.T. (1991). Transient homologous μ-opioid receptor desensitization in rat locus coeruleus neurons. J. Neurosci., 11, 2574-2581.
10. HAUSDORFF, W.P., CARON, M.G. & LEFKOWlTZ, R.J. (1990). Turning off the signal: desensitization of β-adrenergic receptor function. FASEB J., 4, 2881-2889.
11. 2+ channels by G-protein βγ subunits. Nature, 380, 258-262.
12. HUGANIR, R.L. & GREENGARD, P. (1990). Regulation of neurotransmitter receptor desensitization by protein phosphorylation. Neuron, 5, 555-567.
13. IKEDA, S.R. (1991). Double-pulse calcium channel current facilitation in adult rat sympathetic neurones. J. Physiol., 439, 181-214.
14. IKEDA, S.R. (1996). Voltage-dependent modulation of N-type calcium channels by G-protein βγ subunits. Nature, 380, 255-258.
15. ITO, I., HIRONO, C., YAMAGISHI, S., NOMURA, Y., KANEKO, S. & SUGIYAMA, H. (1988). Roles of protein kinases in neurotransmitter responses in Xenopus oocytes injected with rat brain mRNA. J. Cell. Physiol., 134, 155-160.
16. JOHNSON, P.S., WANG, J.B., WANG, W.F. & UHL, G.R. (1994). Expressed mu opiate receptor couples to adenylate cyclase and phosphatidyl inositol turnover. NeuroReport, 5, 507-509.
17. 2+ channel inhibition by κ opioid receptors expressed in Xenopus oocytes. NeuroReport, 5, 2506-2508.
18. 2+ and stimulation of cyclic AMP production by κ opioid receptors expressed in Xenopus oocytes. Mol. Brain Res., 27, 258-264.
19. KATO, K., KANEKO, S. & NOMURA, Y. (1988). Phorbol ester inhibition of current responses and simultaneous protein phosphorylation in Xenopus oocyte injected with brain mRNA. J. Neurochem., 50, 766-773.
20. KENNEDY, C. & HENDERSON, G. (1991). μ-opioid receptor inhibition of calcium current: development of homologous tolerance in single SH-SY5Y cells after chronic exposure to morphine in vitro. Mol. Pharmacol., 40, 1000-1005.
21. KOVOORM, A., HENRY, D.J. & CHAVKIN, C. (1995). Agonist-induced desensitization of the mu opioid receptor-coupled potassium channel (GIRK1). J. Biol. Chem., 270, 589-595.
22. LUTFY, K & YOBURN, B.C. (1991). The role of opioid receptor density in morphine tolerance. J. Pharmacol. Exp. Ther., 256, 575-580.
23. MESTEK, A., HURLEY, J.H., BYE, L.S., CAMPBELL, A.D., CHEN, Y., TIAN, M., LIU, J., SCHULMAN, H. & YU, L. (1995). The human μ opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C. J. Neurosci., 15, 2396-2406.
24. MINAMI, M., ONOGI, T., TOYA, T., KATAO, Y., HOSOI, Y., MAEKAWA, K., KATSUMATA, S., YABUUCHI, K. & SATOH, M. (1994). Molecular cloning and in situ hybridization histochemistry for rat μ-opioid receptor. Neurosci. Res., 18, 315-322.
25. MINAMI, M., TOYA, T., KATAO, Y., MAEKAWA, K., NAKAMURA, S., ONOGI, T., KANEKO, S. & SATOH, M. (1993). Cloning and expression of a cDNA for the rat κ-opioid receptor. FEBS Lett., 329, 291-295.
26. o-type GTP-binding protein. J. Neurosci., 14, 3842-3851.
27. MORI, Y., FRIEDRICH, T., KIM, M.-S., MIKAMI, A., NAKAI, J., RUTH, P., BOSSE, E., HOFMAN, F., FLOCKERZl, V., FURUICHI, T., MIKOSHIBA, K., IMOTO, K., TANABE, T. & NUMA, S. (1991). Primary structure and functional expression from complementary DNA of a brain calcium channel. Nature, 350, 398-402.
28. NISHINO, K., SU, Y.F., WONG, C.-S., WATKINS, W.D. & CHANG, K.-J. (1990). Dissociation of mu opioid tolerance from receptor down-regulation in rat spinal cord. J. Pharmacol. Exp. Ther., 253, 67-72.
29. NOMURA, K., REUVENY, E. & NARAHASHI, T. (1994). Opioid inhibition and desensitization of calcium channel currents in rat dorsal root ganglion neurons. J. Pharmacol. Exp. Ther., 270, 466-474.
30. OSBORNE, P.B. & WILLIAMS, J.T. (1995). Characterization of acute homologous desensitization of μ-opioid receptor-induced currents in locus coeruleus neurones. Br. J. Pharmacol., 115, 925-932.
31. PEI, G., KIEFFER, B.L., LEFKOWITZ, R.L. & FREEDMAN, N.L. (1995). Agonist-dependent phosphorylation of the mouse δ-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C. Mol. Pharmacol., 48, 173-177.
32. RAYNOR, K., KONG, H., HINES, J., KONG, G., BENOVIC, J., YASUDA, K., BELL, G.I. & REISINE, T. (1994). Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor. J. Pharmacol. Exp. Ther., 270, 1381-1386.
33. REUVENY, E., SLESINGER, P.A., INGLESE, J., MORALES, J.M., IÑIGUEZ-LLUHI, J.A., LEFKOWITZ, R.J., BOURNE, H.R., JAN, Y.N. & JAN, L.Y. (1994). Activation of the cloned muscarinic potassium channel by G protein βγ subunits. Nature, 370, 143-146.
34. RHIM, H. & MILLER, R.J. (1994). Opioid receptors modulate diverse types of calcium channels in the nucleus tractus solitarius of the rat. J. Neurosci., 14, 7608-7615.
35. 1 subunits. Neuron. 11, 291-303.
36. 2+ currents, but spares a sustained current. Neuron, 6, 13-20.
37. TAUSSIG, R., SANCHEZ, S., RIFO, M., GILMAN, A.G. & BELARDETTI, F. (1992). Inhibition of the ω-conotoxin-sensitive calcium current by distinct G proteins. Neuron, 8, 799-809.
38. 11-phospholipase C activation in Xenopus oocytes. J. Neurosci. 15, 7485-7499.
39. 13 mediates inhibition of voltage-dependent calcium current by bradykinin. Neuron, 13, 1215-1224.
40. ZHANG, L., YU, Y., MACKIN, S., WEIGHT, F.F., UHL, G.R. & WANG, J.B. (1996). Differential opiate receptor phosphorylation and desensitization induced by agonists and phorbol esters. J. Biol. Chem., 211, 11449-11454.