[3H]GBR 12935 binding in platelets: A possible association with cytochrome P-450IID6?

European Journal of Pharmacology

Volumn 332, Issue 2, 1997, Pages 227-230

  Norlén, Maria ^a   Allard, Per ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

3H GBR 12935 binding; Cytochrome P 450IID6; Piperazine acceptor site; Platelet, human

Indexed keywords

1 [2 (BENZHYDRYLOXY)ETHYL] 4 (3 PHENYLPROPYL)PIPERAZINE; 1,3 BIS(2 METHYLPHENYL)GUANIDINE; ALAPROCLATE; BUDIPINE; COCAINE; CYTOCHROME P450 ISOENZYME; DEBRISOQUINE; DEXTROMETHORPHAN; DIZOCILPINE; DOPAMINE; FLUPENTIXOL; HALOPERIDOL; LOBELINE; MAZINDOL; N ALLYLNORMETAZOCINE; PRECLAMOL; PROADIFEN; QUINIDINE; SPARTEINE; VANOXERINE; CYTOCHROME P450; DOPAMINE RECEPTOR BLOCKING AGENT; ENZYME INHIBITOR; LIGAND; NEUROLEPTIC AGENT; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE;

ARTICLE; BINDING SITE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MEMBRANE BINDING; PRIORITY JOURNAL; THROMBOCYTE; CULTURE TECHNIQUE; METABOLISM;

ANTIPSYCHOTIC AGENTS; BLOOD PLATELETS; CULTURE TECHNIQUES; CYTOCHROME P-450 ENZYME SYSTEM; DOPAMINE ANTAGONISTS; ENZYME INHIBITORS; FLUPENTHIXOL; HUMANS; LIGANDS; LOBELINE; PIPERAZINES; PIPERIDINES; QUINIDINE;

EID: 0030612513     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01094-7     Document Type: Article

References (16)

1. 3H]GBR 12935 binding to cytochrome P-450 in human brain. J. Neurochem. 62, 342-348.
2. 2+ stores. Biochem. J. 280, 783-789.
3. Fonne-Pfister, R., Meyer, U.A., 1988. Xenobiotic and endobiotic inhibitors of cytochrome P-450db1 function, the target of the debrisoquine/sparteine type polymorphism. Biochem. Pharmacol. 37, 3829-3835.
4. Fonne-Pfister, R., Bargetzi, M.J., Meyer, U.A., 1987. MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalysing debrisoquine 4 hydroxylation. Biophys. Res. Commun. 148, 1144-1150.
5. 3H]GBR 12935 binding to human platelet membranes is sensitive to piperazine derivatives but not to dopamine uptake inhibitors. Life Sci. 55, 189-199.
6. Haurand, M., Ullrich, V., 1985. Isolation and characterization of thromboxane synthase from human platelets as a cytochrome P-450 enzyme. J. Biol. Chem. 260, 15059-15067.
7. 3H]dextromethorphan and σ-ligands to guinea pig brain. Life Sci. 48, 543-550.
8. 3H]Imipramine binding of protein nature in human platelets: Inhibition by 5-hydroxytryptamine and 5-hydroxytryptamine uptake inhibitors. J. Neurochem. 50, 1032-1036.
9. Munson, P.J., Rodbard, D., 1980. Ligand: a versatile computerized approach for characterization of ligand binding systems. Anal. Biochem. 107, 220-239.
10. 3H]GBR-12935 binding proteins. Arch. Biochem. Biophys. 276, 424-432.
11. Otton, S.V., Tyndale, R.F., Wu, D., Inaba, T., Kalow, W., Sellers, E.M., 1992. Catalytic and immunologie similarities between monkey and human liver cytochrome P-450db1 (human cytochrome P-450 2D6). Drug Metab. Dispos. 20, 1-5.
12. Ross, S.B., 1991. Heterogenous binding of sigma radioligands in the rat brain and liver: Possible relationship to subforms of cytochrome P-450. Pharmacol. Toxicol. 68, 293-301.
13. 3H-alaproclate to membranes from rat cerebral cortex. Pharmacol. Toxicol. 67, 288-292.
14. + channel cDNA. Neuropharmacology 33, 795-804.
15. Testa, B., Jenner, P., 1982. Inhibitors of cytochrome P-450s and their mechanism of action. Drug Metab. Rev. 12, 1-117.
16. Tyndale, R.F., Sunahara, R., Inaba, T., Kalow, W., Gonzales, F.J., Niznik, H.B., 1991. Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): Potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6. Mol. Pharmacol. 40, 63-68.