Simiam immunodeficiency viruses containing mutations in the long terminal repeat NF-B or Sp1 binding sites replicate efficiently in T cells and PHA-stimulated PBMCs

Virus Research

Volumn 49, Issue 2, 1997, Pages 205-213

  Zhang, Jianbo ^a   Novembre, Francis ^b   Rabson, Arnold B ^a  

^a RUTGERS UNIVERSITY   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

Long terminal repeat; NF B; Simian immunodeficiency virus; Sp1

Indexed keywords

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; LONG TERMINAL REPEAT; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS MUTANT; VIRUS REPLICATION; VIRUS TRANSCRIPTION; ANIMAL; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL LINE; CHEMISTRY; GENETICS; MACACA; METABOLISM; MOLECULAR GENETICS; MONONUCLEAR CELL; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS; T LYMPHOCYTE; VIROLOGY;

DNA BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHYTOHEMAGGLUTININ; PROTEIN KINASE; SP1 KINASE;

ANIMALS; BASE SEQUENCE; BINDING SITES; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; DNA-BINDING PROTEINS; LEUKOCYTES, MONONUCLEAR; MACACA MULATTA; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NF-KAPPA B; PHYTOHEMAGGLUTININS; PROTEIN KINASES; REPETITIVE SEQUENCES, NUCLEIC ACID; SIMIAN IMMUNODEFICIENCY VIRUS; T-LYMPHOCYTES; TUMOR CELLS, CULTURED; VIRUS REPLICATION;

EID: 0030612439     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1702(97)01462-7     Document Type: Article

References (33)

1. Alcami, J., Lain de Lera, T., Folgueira, L., Pedraza, M.-A., Jacque, J.M., Bachelerie, F., Noriega, A.R., Hay, R.T., Harrich, D., Gaynor, R.B., Virelizier, J.-L. and Arenzana-Seisdedos, F. (1995) Absolute dependence on kB responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes. EMBO. J. 14, 1552-1560.
2. mac239 in T-cell lines and macrophage cell lines. J. Virol. 65, 51-60.
3. Antoni, B.A., Stein, S.B. and Rabson, A.B. (1994) Regulation of human immunodeficiency virus infection: implications for pathogenesis. In: K. Maramorosch, F.A. Murphy and A.J. Shatkin (Eds), Advances in Virus Research, Academic Press, New York, Vol. 43, pp. 53-145.
4. Bellas, R.E., Hopkins, N. and Li, Y. (1993) The NF-κB binding site is necessary for efficient replication of simian immunodeficiency virus of macaques in primary macrophages but not in T cells in vitro. J. Virol. 67, 2908-2913.
5. Clements, J.E. and Payne, S.L. (1994) Molecular basis of the pathobiology of lentiviruses. Virus Res. 32, 97-109.
6. Cullen, B.R. (1992) Mechanism of action of regulatory proteins encoded by complex retroviruses. Microbiol. Rev. 56, 375-394.
7. smm-pbj14. Nature (London) 345, 636-639.
8. smmPBj14. J. Virol. 68, 7800-7809.
9. Duh, E.J., Maury, W.J., Folks, T.M., Fauci, A.S. and Rabson, A.B. (1989) Tumor necrosis factor a activates human immunodeficiency virus-1 through induction of nuclear factor binding to the NF-κB sites in the long terminal repeat. Proc. Natl. Acad. Sci. USA 86, 5974-5978.
10. Fultz, P.N., Gluckman, J.C., Muchmore, E. and Girard, M. (1992) Transient increases in numbers of infectious cells in an HIV-1 infected chimpanzee following immune stimulation. AIDS Res. Hum. Retraviruses 8, 313-317.
11. Gaynor, R. (1992) Cellular transcriptional factors involved in the transcriptional regulation of HIV-1 gene expression. AIDS 6, 347-363.
12. Hirsch, V.M. and Johnson, P.R. (1994) Pathogenic diversity of simian immunodeficiency viruses. Virus Res. 32, 183-203.
13. Ilyinskii, P.O. and Desrosiers, R.C. (1996). Efficient transcription and replication of simian immunodeficiency virus in the absence of NF-κB and Sp1 binding elements. J. Virol. 70, 3118-3126.
14. Jeang, K. and Gatignol, A. (1994). Comparison of regulatory features among primate lentiviruses. Curr. Top. Microbial. Immunol. 188, 123-144.
15. Jones, K.A., Kadonaga, J.T., Luciw, P.A. and Tjian, R. (1986). Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1. Science. 232, 755-759.
16. Kestler, H., Kodama, T., Ringler, D., Marthas, M., Pedersen, N., Lackner, A., Regier, D., Sehgal, P., Daniel, M., King, N. and Desroslers, R. (1990) Induction of AIDS in Rhesus Monkeys by molecularly cloned simian immunodeficiency virus. Science 248, 1109-1112.
17. Kestler III, H.W., Ringler, D.J., Mon, K., Panicali, D.L., Sehgal, P.K., Daniel, M.D. and Desrosiers, R.C. (1991) Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65, 651-662.
18. Kim, J.Y., Gonzalez-Scarano, F., Zeichner, S.L. and Alwine, J.C. (1993) Replication of type 1 human immunodeficiency viruses containing linker substitution mutations in the - 201 to - 130 region of the long terminal repeat. J. Virol. 67, 1658-1662.
19. Leonard, J., Parrott, C., Buckler-White, A.J., Turner, W., Ross, E.K., Martin, M.A. and Rabson, A.B. (1989) The NF-kappa B binding sites in the human immunodeficiency virus type 1 long terminal repeat are not required for virus infectivity. J. Virol. 63, 4919-4924.
20. Letvin, N.L. and King, N.W. (1990) Immunologic and pathologic manifestations of the infection of rhesus monkeys with simian immunodeficiency virus of macaques. J. Acquir. Immune Def. Syndr. 3, 1023-1040.
21. McClure, H.M., Anderson, D.C., Ansari, A.A., Fultz, P.N., Klumpp, S.A. and Schinazi, R.F. (1990) Nonhuman primate models for evaluation of AIDS therapy. Ann. NY Acad. Sci. 616, 287-298.
22. Miyamoto, S. and Verma, I.M. (1995) Rel/NF-kB/lkB story. Adv. Cancer Res. 66, 255-292.
23. Novembre, F.J., Johnson, P.R., Lewis, M.G., Anderson, D.C., Klumpp, S., McClure, H.M. and Hirsch, V.M. (1993) Multiple viral determinants contribute to pathogenicity of the acutely lethal simian immunodeficiency virus SIV-smmPBj variant. J. Virol. 67, 2466-2474.
24. O'Brien, W.A., Grovit-Ferbas, K., Namazi, A., Ovcak-Derzic, S., Wang, H.J., Park, J., Yeramlan, C., Mao, S.H. and Zack, J.A. (1995) Human immunodeficiency virus-type 1 replication can be increased in peripheral blood of seropositive patients after influenza vaccination. Blood 86, 1082-1089.
25. Parrott, C., Seidner, T., Duh, E., Leonard, J., Theodore, T.S., Buckler-White, A., Martin, M.A. and Rabson, A.B. (1991) Variable role of the long terminal repeat Sp1-binding sites in human immunodeficiency virus replication in T Lymphocytes. J. Virol. 65, 1414-1419.
26. Renjifo, B., Speck, N.A., Winandy, S., Hopkins, N. and Li, Y. (1990) cis-acting elements in the U3 region of a simian immunodeficiency virus. J. Virol. 64, 3130-3134.
27. Ross, E.K., Buckler-White, A.J., Rabson, A.B., Englund, G. and Martin, M.A. (1991) Contribution of NF-kappa B and Sp1 binding motifs to the replicative capacity of human immunodeficiency virus type 1: distinct patterns of viral growth are determined by T-cell types. J. Virol. 65, 4350-4358.
28. Salter, R.D., Howell, D.N. and Cresswell, P. (1985) Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids. Immunogenetics 21, 235-246.
29. smmPBj14: correlation between in vitro and in vivo events. J. Virol. 68, 5538-5547.
30. Simon, M.A., Brodie, S.J., Sasseville, V.G., Chalifoux, L.V., Desrosiers, R. and Ringler, D.J. (1994) Immunopathogenesis of SIVmac. Virus Res. 32, 227-251.
31. Stanley, S.K., Ostrowski, M.A., Justement, J.S., Gantt, K., Heydayati, S., Mannix, M., Roche, K., Schwartzentruber, D.J., Fox, C.H. and Fauci, A.S. (1996) Effect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1. N. Engl. J. Med. 334, 1222-1230.
32. Staprans, S.I., Hamilton, B.L., Follansbee, S.E., Elbelk, T., Barbosa, P., Grant, R.M. and Feinberg, M.B. (1995) Activation of virus replication after vaccination of HIV-1-infected individuals. J. Exp. Med. 182, 1727-1737.
33. Winandy, S., Renjifo, B., Li, Y. and Hopkins, N. (1992) Nuclear factors that bind two regions important to transcriptional activity of the simian immunodeficiency virus long terminal repeat. J. Virol. 66, 5216-5223.