Comparative 32P-postlabeling analysis of exogenous and endogenous DNA adducts in mouse skin exposed to a wood-preserving waste extract, a complex mixture of polycyclic and polychlorinated chemicals

Environmental and Molecular Mutagenesis

Volumn 29, Issue 4, 1997, Pages 372-378

  Randerath, K ^a   Zhou, G D ^a   Randerath, E ^a   Safe, S H ^b   Donnelly, K C ^c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

32P postlabeling; DNA adducts; DNA damage; I compounds; Oxidative stress; Wood preserving waste

Indexed keywords

CYTOCHROME P450; DIBENZOFURAN; DNA; PHENOL DERIVATIVE; PHOSPHORUS 32; POLYCHLORINATED DIBENZODIOXIN; POLYCYCLIC AROMATIC HYDROCARBON; TOXIC SUBSTANCE; WOOD PROTECTING AGENT; ACETONE; FREE RADICAL; NUCLEASE S1; PENTACHLOROPHENOL; PHOSPHORUS;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; CARCINOGENESIS; CHEMICAL REACTION; CHEMICAL WASTE; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; FEMALE; MOUSE; NONHUMAN; SKIN; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; INSTITUTE FOR CANCER RESEARCH MOUSE; ISOTOPE LABELING; METABOLISM; METHODOLOGY; POLLUTION; WOOD;

ACETONE; ANIMALS; ASPERGILLUS NUCLEASE S1; DNA ADDUCTS; FEMALE; FREE RADICALS; ISOTOPE LABELING; MICE; MICE, INBRED ICR; PENTACHLOROPHENOL; PHOSPHORUS RADIOISOTOPES; POLYCYCLIC HYDROCARBONS, AROMATIC; SKIN; WASTE PRODUCTS; WOOD;

EID: 0030612412     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1997)29:4<372::AID-EM5>3.0.CO;2-C     Document Type: Article

References (47)

1. Cadet J (1994): DNA damage caused hy oxidation, deamination, ultraviolet radiation and photoexcited psoralens. In: Hemminki K, Dipple A, Shuker DEG, Kadlubar FF, Segerback D, Bartsch H (eds), "DNA Adducts: Identification and Biological Significance." IARC Scient. Publ. 125. Lyon: International Agency for Research on Cancer, pp 245-276.
2. 32P-postlabeling of DNA adducts induced by a Fenton-type oxygen radical-generating system. Carcinogenesis 13:1127-1135.
3. Copeland TL, Paustenbach DJ, Harris MA, Otani J (1993): Comparing the results of a Monte Carlo analysis with EPA's reasonable maximum exposed individual (RMEI): A case study of a former wood treatment site. Regul Toxicol Pharmacol 18:275-312.
4. Dipple A, Moschel RC, Bigger CAH (1984): Polynuclear aromatic carcinogens. In: Searle CA (ed), "Chemical Carcinogens." American Chemical Society Monograph 182. Washington, DC: American Chemical Society, pp 41-163.
5. Dizdaroglu M (1992): Oxidative damage to DNA in mammalian chromatin. Mutat Res 275:331-342.
6. Donnelly KC, Brown KW, Kampbell D (1987a): Chemical and biological characterization of hazardous industrial waste. I. Prokaryotic bioassays and chemical analysis of a wood-preserving bottom-sediment waste. Mutat Res 189:31-42.
7. Donnelly KC, Brown KW, Scott BR (1987b): Chemical and biological characterization of hazardous industrial waste. II. Eukaryotic bioassay of a wood-preserving bottom sediment. Mutat Res 180:43-53.
8. Donnelly KC, Safe SH, Randerath K, Randerath E (1995): Bioassay-based risk assessment of complex mixtures. J Hazard Mater 41:341-350.
9. Feig DI, Reid TM, Loeb LA (1994): Reactive oxygen species in tumorigenesis. Cancer Res (Suppl) 54:1890s-1894s.
10. Fraga CG, Shigenaga MK, Park J-W, Degan P, Ames BN (1990): Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci USA 87:4533-4537.
11. Frenkel K (1992): Carcinogen-mediated oxidant formation and oxidative DNA damage. Pharmacol Ther 53:127-166.
12. Gupta RC (1984): Non-random binding of the carcinogen N-hydroxy-2-acetylaminofluorene in repetitive sequences of rat liver DNA in vivo. Proc Natl Acad Sci USA 81:6943-6947.
13. Guyton KZ, Kensler TW (1993): Oxidative mechanisms in carcinogenesis. Br Med Bull 49:523-544.
14. Halliwell B, Aruoma O (1991): DNA damage by oxygen-derived species. FEBS Lett 281:9-19.
15. Han X, Liehr JG (1994): 8-Hydroxylation of guanine bases in kidney and liver DNA of hamsters treated with estradiol: Role of free radicals in estrogen-induced carcinogenesis. Cancer Res 54: 5515-5517.
16. Harvey RG (1991): "Aromatic Hydrocarbons: Chemistry and Carcinogenicity." Cambridge, UK: Cambridge University Press.
17. Hirano T, Homma Y, Kasai H (1995): Formation of 8-hydroxyguanine in DNA by aging and oxidative stress. In: Cutler RG, Packer L, Bertram J, Mori A (eds), "Oxidative Stress and Aging." Basel, Switzerland: Birkhuser Verlag.
18. Johnson BL (1995): Nature, extent, and impact of Superfund hazardous waste sites. Chemosphere 31:2415-2418.
19. 1 (DT diaphorase) specifically prevents the formation of benzo(a)pyrene quinone-DNA adducts generated by cytochrome P4501A1 and P450 reductase. Proc Natl Acad Sci USA 91:8413-8417.
20. Kaneko T, Tahara S, Matsuo M (1996): Non-linear accumulation of 8-hydroxy-2′-deoxyguanosine, a marker of oxidized DNA damage, during aging. Mutat Res 316:277-285.
21. Loft S, Fischer-Nielsen A, Jeding IB, Vistisen K, Poulsen HE (1993): 8-Hydroxydeoxyguanosine as a urinary biomarker of oxidative DNA damage. J Toxicol Environ Health 40:391-404.
22. Malins DC, Gunselman SJ (1994): Fourier-transform infrared spectroscopy and gas chromatography-mass spectrometry reveal a remarkable degree of structural damage in the DNA of wild fish exposed to toxic chemicals. Proc Natl Acad Sci USA 91:13038-13041.
23. Moorthy B, Randerath K (1996): Pentachlorophenol enhances 9-hydroxybenzo[a]pyrene-induced hepatic DNA adduct formation in vivo and inhibits microsomal epoxide hydrolase and glutathione S-transferase activities in vitro: Likely inhibition of epoxide detoxication by pentachlorophenol. Arch Toxicol 70:696-703.
24. Moorthy B, Sriram P, Randerath K (1994): Chemical structure- and time-dependent effects of polycyclic aromatic hydrocarbon-type inducers on rat liver cytochrome P450, DNA adducts, and I-compounds. Fund Appl Toxicol 22:549-560.
25. Moorthy B, Sriram P, Randerath K (1995): Effects of a single dose of the cytochrome P450 inducer, β-naphthoflavone, on hepatic and renal covalent DNA modifications (I-compounds). Toxicology 104:165-177.
26. Muellcr JG, Middaugh DP, Lantz SE, Chapman PJ (1991): Biodegradation of creosote and pentachlorophenol in contaminated groundwater: Chemical and biological assessment. Appl Environ Microbiol 57:1277-1285.
27. 32P-postlabeling. Carcinogenesis 17:109-114.
28. 32P-postlabeling. Comparison with cigarette smoke-associated DNA adduct profiles in vivo. Mutat Res 268:139-153.
29. Randerath E, Randerath K, Reddy R, Narasimhan TR, Wang X, Safe S (1993): Effects of polychlorinated dibenzofurans on I-compounds in hepatic DNA of female Sprague-Dawley rats. Structure dependence and mechanistic considerations. Chem-Biol Interact 88:175-190.
30. Randerath E, Watson WP, Zhou G-D, Chang J, Randerath K (1995a): Intensification and depletion of specific bulky renal DNA adducts (I-compounds) following exposure of male F344 rats to the renal carcinogen ferric nitrilotriacetate (Fe-NTA) Mutat Res 341:265-279.
31. 32P-postlabeling. Arch Toxicol 70:683-695.
32. Randerath E, Zhou G-D, Hart RW, Randerath K (1995b): Age-dependent indigenous covalent DNA modifications (I-compounds). In: Hart RW, Neumann DA, Robertson RT (eds), "Dietary Restriction: Implications for the Design and Interpretation of Toxicity and Carcinogenicity Studies." Washington, DC: ILSI Press, pp 229-244.
33. Randerath E, Zhou G-D, Randerath K (1996b): Organ-specific oxidative DNA damage associated with normal birth in rats. Carcinogenesis 17:2563-2570.
34. Randerath K, Chang J, Randerath E (1995): Age-dependent DNA modifications (I-compounds): Effects of carcinogenesis and oxidative stress. In: Cutler RG, Packer L, Bertram J, Mori A (eds), "Oxidative Stress and Aging." Basel, Switzerland: Birkhuser Verlag, pp 77-87.
35. 32P-postlabeling assay and possible significance for spontaneous tumor induction and aging. Carcinogenesis 7:1615-1617.
36. Randerath K, Putman KL, Randerath E, Mason G, Kelley M, Safe S (1988): Organ-specific effects of long term feeding of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 1,2,3,7,8-pentachlorodibenzo-pdioxin on I-compounds in hepatic and renal DNA of female Sprague-Dawley rats. Carcinogenesis 9:2285-2289.
37. 32P-Postlabeling methods for DNA adduct detection: Overview and critical evaluation. Drug Metabol Rev 26:67-85.
38. Randerath K, Randerath E, Smith CV, Chang J (1996): Structural origins of bulky oxidative DNA adducts (Type II I-compounds) as deduced by oxidation of oligonucleotides of known sequence. Chem Res Toxicol 9:247-254.
39. 32P-Labeling test for DNA damage. Proc Natl Acad Sci USA 78:6126-6129.
40. 32P-postlabeling in DNA modified by oxidative damage in vitro. Comparison with rat lung I-compounds. Mutat Res 250:135-144.
41. 32P-postlabeling. Cancer Lett 83:123-128.
42. 32P-Postlabeling test for covalent DNA binding of chemicals in vivo: Application to a variety of aromatic carcinogens and methylating agents. Carcinogenesis 5:231-243.
43. 32P-postlabeling test for structurally diverse DNA adducts. Carcinogenesis 7:1543-1551.
44. Safe S (1990): Polychlorinated biphenyls (PCBs). dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds; environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Crit Rev Toxicol 21:51-88.
45. Stone K, Bermudez E, Zang LY, Carter KM, Queeman KE, Pryor WA (1995): The ESR properties. DNA nicking, and DNA association of aged solutions of catechol versus aqueous extracts of tar from cigarette smoke. Arch Biochem Biophys 319:196-203.
46. Walles SA (1992): Mechanisms of DNA damage induced in rat hepatocytes by quinones. Cancer Lett 63:47-52.
47. Zang L-Y, Stone K, Pryor WA (1995): Detection of free radicals in aqueous extracts of cigarette tar by electron spin resonance. Free Radic Biol Med 19:161-167.