Transmission of a homogeneous hepatitis B virus population of A1896- containing strains leading to mild resolving acute hepatitis and seroconversion to hepatitis B e antigen antibodies in an adult

Hepatology

Volumn 26, Issue 3, 1997, Pages 743-746

  Mphahlele, M Jeffrey ^a,b   Shattock, Alan G ^c   Boner, Winifred ^a   Quinn, Jacqueline ^c   McCormick, P Aiden ^d   Carman, William F ^a,e  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b SEFAKO MAKGATHO HEALTH SCIENCES UNIVERSITY   (South Africa)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

^d ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^e INSTITUTE OF VIROLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN; HEPATITIS B ANTIBODY; IMMUNOGLOBULIN M; PRIMER DNA;

ADULT; ANTIBODY PRODUCTION; ARTICLE; CASE REPORT; DISEASE SEVERITY; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOLECULAR DYNAMICS; OUTCOMES RESEARCH; PHYLOGENY; PRIORITY JOURNAL; SEROCONVERSION; STRAIN DIFFERENCE; VIRUS TRANSMISSION; BLOOD; DISEASE TRANSMISSION; GENETICS; HEPATITIS B; IMMUNOLOGY; ISOLATION AND PURIFICATION; LIVER FUNCTION TEST; MIDDLE AGED; POLYMERASE CHAIN REACTION; SPOUSE; VIROLOGY;

DNA PRIMERS; HEPATITIS B; HEPATITIS B ANTIBODIES; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HUMANS; IMMUNOGLOBULIN M; LIVER FUNCTION TESTS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; SPOUSES;

EID: 0030612251     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510260329     Document Type: Article

References (20)

1. Carman WF, Jacyna MR, Hadziyannis S, Karayiannis P, McGarvey M, Makris A, Thomas HC. Mutation preventing formation of e antigen in patients with chronic HBV infection. Lancet 1989;ii:588-591.
2. Brunetto MR, Stemmler M, Schodel F, Will H, Ottobrelli A, Rizzetto M, Bonino F. Identification of HBV variants which cannot produce precore-derived HBeAg and may be responsible for severe hepatitis. Ital J Gastroenterol 1989;21:151-154.
3. Günther S, Meisel H, Reip A, Miska S, Krüger DH, Will H. Frequent and rapid emergence of mutated pre-C sequences in HBV from e-antigen positive carriers who seroconvert to anti-HBe during interferon treatment. Virology 1992;187:271-279.
4. Tong S, Li J, Vitvitski L, Trepo C. Active hepatitis B virus replication in the presence of anti-HBe is associated with viral variants containing an inactive pre-C region. Virology 1990;176:596-603.
5. Tong SP, Li JS, Vitvitski L, Trèpo C. Replication capacities of natural and artificial precore stop codon mutants of hepatitis B virus: relevance of pregenome encapsidation signal. Virology 1992;191:237-245.
6. Lok ASF, Akarca U, Greene S. Mutations in the pre-core region of the hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal. Proc Natl Acad Sci USA 1994; 91:4077-4081.
7. Okamoto H, Yotsumoto S, Akahane Y, Yamanaka T, Miyazaki Y, Sugai Y, Tsuda F, et al. Hepatitis B viruses with pre-core region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol 1990;64:1298-1303.
8. Tur-Kaspa R, Klein A, Aharonson S. Hepatitis B virus precore mutants are identical in carriers from various ethnic origins and are associated with a range of liver disease severity. HEPATOLOGY 1992;16:1338-1342.
9. Kosaka Y, Takase K, Kojima M, Shimizu M, Inoue K, Yoshiba M, Tanaka S, et al. Fulminant hepatitis B: induction by hepatitis B virus mutants defective in the precore region and incapable of encoding e antigen. Gastroenterology 1991;324:1087-1094.
10. Carman WF, Fagan EA, Hadziyannis S, Karayiannis P, Tassopoulos NC, Williams R, Thomas HC. Association of a pre-core genomic variant of HBV with fulminant hepatitis. HEPATOLOGY 1991;14:219-222.
11. Laskus T, Persing DH, Nowicki MJ, Mosley JW, Rakela J. Nucleotide sequence analysis of the precore region in patients with fulminant hepatitis B in the United States. Gastroenterology 1993;105:1173-1178.
12. Raimondo G, Tanzi E, Brancatelli S, Campo S, Sardo MA, Rodinó G, Pernice M, et al. Is the course of perinatal hepatitis B virus infection influenced by genetic heterogeneity of the virus? J Med Virol 1993;40: 87-90.
13. Aye TT, Uchida T, Becker SO, Hirashima M, Shikata T, Komine F, Moriyama M, et al. Variations of hepatitis B virus precore/core gene sequence in acute and fulminant hepatitis B. Dig Dis Sci 1994;39:1281-1287.
14. Liang TJ, Hasegawa K, Rimon N, Wands JR, Ben-Porath E. A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. N Engl J Med 1991;324:1705-1709.
15. Omata M, Ehata T, Yokosuka O, Hosoda K, Ohio M. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N Engl J Med 1991;324:1699-1704.
16. Carman WF, Thursz M, Hadziyannis S, McIntyre G, Colman K, Gioustozi A, Fattovich G, et al. HBeAg negative chronic active hepatitis: HBV core mutations occur predominantly in known antigenic determinants. J Viral Hepat 1995;2:77-84.
17. Carman WF, Trautwein C, van Deursen FJ, Colman K, McIntyre G, Dornan E, Waters J, et al. Hepatitis B virus envelope variation after transplantation with and without hepatitis B immune globulin prophylaxis. HEPATOLOGY 1996;24:489-493.
18. Baumert TF, Rogers SA, Hasagawa K, Liang TJ. HBV core promotor mutations cause enhanced viral replication in association with fulminant hepatitis [Abstract]. HEPATOLOGY 1995;22:260A.
19. Sterneck M, Günther S, Santantonio T, Fischer L, Broelsch CE, Greten H, Will H. Hepatitis B virus genomes of patients with fulminant hepatitis do not share a specific mutation. HEPATOLOGY 1996;24:300-306.
20. Bollyky PL, Yasmin M, Kidd-Ljunggren K, Holmes EC, Fagan EA, Carman WF. Distinct clinical outcomes and mutational patterns charaterize clusters of viruses from epidemiologically independent fulminant hepatitis B cases. 1997; submitted.